Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

ACS Nano, Год журнала: 2023, Номер 17(9), С. 7979 - 8003

Опубликована: Апрель 27, 2023

Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT PTT at the cellular, vascular tumor microenvironmental levels, as well translating both modalities clinic. Emerging evidence suggests that may synergize due their different mechanisms action, nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations gained momentum recent years development multimodal nanoplatforms simultaneously incorporate photodynamically- photothermally active agents. In this review, we discuss how combining can address limitations each modality alone enhance treatment safety efficacy. We provide an overview literature featuring dual nanoparticles analyze strengths various nanoparticle design strategies. also detail sequence dose affect cellular states, pathophysiology drug delivery, ultimately shaping response. Lastly, common experimental pitfalls complicate preclinical assessment propose rational guidelines elucidate underlying interactions.

Язык: Английский

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Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Multicharged cyclodextrin supramolecular assemblies

Chemical Society Reviews, Год журнала: 2022, Номер 51(11), С. 4786 - 4827

Опубликована: Янв. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Язык: Английский

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Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Год журнала: 2022, Номер 35(18)

Опубликована: Ноя. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Язык: Английский

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Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(28), С. 12825 - 12833

Опубликована: Июль 5, 2022

The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through assembly aggregation-induced emission-active four-arm ligand 90° Pt acceptors Pt(PEt3)2(OTf)2. held longest maximum wavelength (1005 nm) compared those previously reported SCCs up to now exhibited both high photothermal conversion efficiency (39.3%) superior reactive oxygen species generation behavior precursor ligand. vitro vivo assessments demonstrated that metallacage-loaded nanoparticles excellent biocompatibility stability were capable simultaneously affording precise tumor diagnosis complete elimination by means NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.

Язык: Английский

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Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

Molecules, Год журнала: 2022, Номер 27(17), С. 5436 - 5436

Опубликована: Авг. 25, 2022

In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due lack tumor selectivity and present pharmacokinetic drawbacks, including low water solubility, that negatively affect drug circulation time bioavailability. The stability studies, performed in mild conditions during their development or under stressing exposure temperature, hydrolytic medium light source, have demonstrated sensitivity parameters. For this reason, formation degradation products is assessed both pharmaceutical formulations environment as hospital waste. To date, numerous been developed for achieving tissue-specific targeting reducing toxic side effects, well improving stability. prodrugs represents a promising strategy targeted cancer therapy selectivity, efficacy active compounds. Recent studies show incorporation into vesicular systems, such polymeric micelles cyclodextrins, use nanocarriers containing chemotherapeutics conjugate monoclonal antibodies can improve pharmacokinetics, cellular absorption study, we summarize latest advances knowledge regarding effective highly stable formulated entrapped nanosystems.

Язык: Английский

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Supramolecular agents for combination of photodynamic therapy and other treatments

Chemical Science, Год журнала: 2021, Номер 12(21), С. 7248 - 7268

Опубликована: Янв. 1, 2021

This review provides a summary of important research progress on supramolecular systems that can be used to combine photodynamic therapy (PDT) with photothermal therapy, chemotherapy, and immunotherapy compensate for the shortcomings PDT.

Язык: Английский

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Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy

Materials Today Bio, Год журнала: 2022, Номер 13, С. 100197 - 100197

Опубликована: Янв. 1, 2022

Photothermal (PT)-enhanced Fenton-based chemodynamic therapy (CDT) has attracted a significant amount of research attention over the last five years as highly effective, safe, and tumor-specific nanomedicine-based therapy. CDT is new emerging nanocatalyst-based therapeutic strategy for in situ treatment tumors via Fenton reaction or Fenton-like reaction, which got fast progress recent because its high specificity activation by endogenous substances. A variety multifunctional nanomaterials such metal-, metal oxide-, metal-sulfide-based nanocatalysts have been designed constructed to trigger within tumor microenvironment (TME) generate cytotoxic hydroxyl radicals (•OH), efficient killing cells. However, still required enhance curative outcomes minimize side effects. Specifically, efficiency certain CDTs hindered TME, including low levels hydrogen peroxide (H2O2), overexpression reduced glutathione (GSH), catalytic efficacy reactions (pH 5.6-6.8), makes it difficult completely cure cancer using monotherapy. For this reason, photothermal (PTT) utilized combination with efficacy. More interestingly, heating during PTT not only causes damage cells but can also accelerate generation •OH reactions, thus enhancing efficacy, providing more effective when compared Currently, synergistic PT-enhanced both PT properties made enormous theranostics. there no comprehensive review on subject published date. In review, we first summarize treatment. We then discuss potential challenges future development nanocatalytic clinical application.

Язык: Английский

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Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(22)

Опубликована: Фев. 27, 2023

Abstract The discovery of the medicinal properties gold complexes has fuelled design and synthesis new anticancer metallodrugs, which have received special attention due to their unique modes action. Current research in development compounds with therapeutic is predominantly focused on molecular drug leads superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive aims at improving physicochemical compounds, such as chemical stability solubility physiological environment. In this regard, encapsulation nanocarriers or grafting onto targeted delivery vectors could lead nanomedicines that eventually reach clinical applications. Herein, we provide an overview state‐of‐the‐art progress andmore importantly thoroughly revise nanoparticle‐based systems for chemotherapeutics.

Язык: Английский

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