Pharmaceuticals,
Год журнала:
2022,
Номер
15(2), С. 190 - 190
Опубликована: Фев. 3, 2022
In
this
focused
progress
review,
the
most
widely
accepted
methods
of
transdermal
drug
delivery
are
hypodermic
needles,
patches
and
topical
creams.
However,
microneedles
(MNs)
(or
microneedle
arrays)
low-invasive
3D
biomedical
constructs
that
bypass
skin
barrier
produce
systemic
localized
pharmacological
effects.
past,
biomaterials
such
as
carbohydrates,
due
to
their
physicochemical
properties,
have
been
extensively
used
manufacture
(MNs).
Due
wide
range
functional
groups,
carbohydrates
enable
design
development
tunable
properties
functionalities.
recent
years,
numerous
products
emerged
on
market,
although
much
research
needs
be
undertaken
overcome
various
challenges
before
successful
introduction
into
market.
As
a
result,
carbohydrate-based
microarrays
high
potential
achieve
future
step
in
sensing,
delivery,
biologics
restitution.
comprehensive
overview
hyaluronic
acid,
chitin,
chitosan,
chondroitin
sulfate,
cellulose
starch
is
discussed
systematically.
It
also
discusses
strategies
mechanical
biomaterial-based
MNs,
made
so
far
clinical
translation
promotional
opportunities
for
commercialization.
conclusion,
article
summarizes
perspectives
which
considered
new
class
systems.
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(16)
Опубликована: Июнь 26, 2021
Abstract
The
universal
increase
in
the
number
of
patients
with
nonhealing
skin
wounds
imposes
a
huge
social
and
economic
burden
on
healthcare
systems.
Although,
application
traditional
wound
dressings
contributes
to
an
effective
healing
outcome,
yet,
complexity
process
remains
major
health
challenge.
Recent
advances
materials
fabrication
technologies
have
led
that
provide
proper
conditions
for
healing.
3D‐printed
dressings,
biomolecule‐loaded
as
well
smart
flexible
bandages
are
among
recent
alternatives
been
developed
accelerate
Additionally,
new
generation
contains
variety
microelectronic
sensors
real‐time
monitoring
environment
is
able
apply
required
actions
support
progress.
Moreover,
manufacturing
enable
development
next
dressing
substrates,
known
electronic
skin,
whole
physiochemical
markers
single
platform.
current
study
reviews
importance
emerging
strategy
care
management
highlights
different
types
promoting
process.
Advanced Materials,
Год журнала:
2021,
Номер
33(39)
Опубликована: Июль 12, 2021
With
all
the
advances
in
tissue
engineering
for
construction
of
fully
functional
skin
tissue,
complete
regeneration
chronic
wounds
is
still
challenging.
Since
immune
reaction
to
damage
critical
regulating
both
quality
and
duration
wound
healing
cascade,
strategies
modulate
system
are
importance.
Generally,
response
an
injury,
macrophages
switch
from
pro-inflammatory
anti-inflammatory
phenotype.
Therefore,
controlling
macrophages'
polarization
has
become
appealing
approach
regenerative
medicine.
Recently,
hydrogels-based
constructs,
incorporated
with
various
cellular
molecular
signals,
have
been
developed
utilized
adjust
cell
functions
stages
healing.
Here,
current
state
knowledge
on
during
first
discussed.
Recent
advanced
technologies
used
design
immunomodulatory
hydrogels
then
summarized.
Rational
providing
controlled
stimulation
via
hydrogel
chemistry
surface
modification,
as
well
incorporation
molecules,
also
dicussed.
In
addition,
effects
hydrogels'
properties
immunogenic
features
process
Finally,
future
directions
upcoming
research
control
responses
highlighted.
Nano-Micro Letters,
Год журнала:
2021,
Номер
13(1)
Опубликована: Март 16, 2021
Abstract
Transdermal
microneedle
(MN)
patches
are
a
promising
tool
used
to
transport
wide
variety
of
active
compounds
into
the
skin.
To
serve
as
substitute
for
common
hypodermic
needles,
MNs
must
pierce
human
stratum
corneum
(~
10
20
µm),
without
rupturing
or
bending
during
penetration.
This
ensures
that
cargo
is
released
at
predetermined
place
and
time.
Therefore,
ability
MN
sufficiently
skin
crucial
requirement.
In
current
review,
pain
signal
its
management
application
typical
needles
presented
compared.
followed
by
discussion
on
mechanical
analysis
models
insertion
tests
before
clinical
practice.
Factors
affect
(e.g.,
geometry,
material
composition
cross-linking
MNs),
along
with
recent
advancements
in
developed
strategies
responsive
3D
printed
biomimetic
using
two-photon
lithography)
improve
penetration
highlighted
provide
backdrop
future
research.
Journal of Controlled Release,
Год журнала:
2022,
Номер
348, С. 186 - 205
Опубликована: Июнь 7, 2022
Microneedles
are
a
rapidly
developing
method
for
the
transdermal
delivery
of
therapeutic
compounds.
All
types
microneedles,
whether
solid,
hollow,
coated,
or
dissolving
function
by
penetrating
stratum
corneum
layer
skin
producing
microchannel
through
which
agents
may
be
delivered.
To
date,
coated
and
hollow
microneedles
have
been
most
successful,
despite
suffering
from
issues
such
as
poor
drug
loading
capabilities
blocked
pores.
Dissolving
on
other
hand,
superior
well
positive
attributes
that
make
it
an
ideal
system,
including
simple
methods
fabrication
disposal,
abundantly
available
materials.
Indeed,
dissolvable
can
even
fabricated
entirely
agent
itself
thus
eliminating
requirement
additional
excipients.
This
focused
review
presents
recent
developments
trends
potential
future
directions.
The
advantages,
disadvantages
materials
discussed.
applications
system
in
different
areas
both
research
literature
clinical
trials
is
highlighted.
Applications
cosmetics,
vaccine
delivery,
diagnosis
monitoring,
cancer,
pain
inflammation,
diabetes,
hair
scalp
disorders
inflammatory
diseases
presented.
current
observed
microneedle
landscape
with
particular
emphasis
contemporary
commercial
successes
barriers
impeding
development
commercialisation
also
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(12)
Опубликована: Май 3, 2021
An
infected
skin
wound
caused
by
external
injury
remains
a
serious
challenge
in
clinical
practice.
Wound
dressings
with
the
properties
of
antibacterial
activity
and
potent
regeneration
capacity
are
highly
desirable
for
healing.
In
this
paper,
degradable,
ductile,
wound-friendly
Zn-MOF
encapsulated
methacrylated
hyaluronic
acid
(MeHA)
microneedles
(MNs)
array
is
fabricated
through
molding
method
promoting
Due
to
damage
capability
against
bacteria
capsule
oxidative
stress
zinc
ion
released
from
Zn-MOF,
such
MNs
presents
excellent
activity,
as
well
considerable
biocompatibility.
Besides,
degradable
composed
photo-crosslinked
MeHA
possesses
superior
capabilities
continuously
steadily
release
loaded
active
ingredients
avoid
secondary
wound.
Moreover,
low
molecular
weight
(HA)
generated
hydrolysis
also
conducive
tissue
regeneration.
Benefiting
these
features,
it
has
been
demonstrated
that
can
dramatically
accelerate
epithelial
neovascularization.
These
results
indicate
combination
MOFs
great
value
Bioengineering & Translational Medicine,
Год журнала:
2021,
Номер
7(1)
Опубликована: Сен. 9, 2021
Abstract
Bacterial
wound
infection
is
one
of
the
most
common
nosocomial
infections.
The
unnecessary
employment
antibiotics
led
to
raising
growth
antibiotic‐resistant
bacteria.
Accordingly,
alternative
armaments
capable
accelerating
healing
along
with
bactericidal
effects
are
urgently
needed.
Considering
this,
we
fabricated
chitosan
(CS)/polyethylene
oxide
(PEO)
nanofibers
armed
antibacterial
silver
and
zinc
nanoparticles.
nanocomposites
exhibited
a
high
antioxidant
effect
activity
against
Staphylococcus
aureus
,
Escherichia
coli
Pseudomonas
aeruginosa
.
Besides,
based
on
results
cell
viability
assays,
optimum
concentration
ZnONPs
AgNPs
in
nanofibrous
mats
0.2%
w/v
0.08%
respectively
had
no
cytotoxicity
fibroblast
cells.
scaffold
also
showed
good
blood
compatibility
according
coagulation
time.
As
well
as
significant
migration
proliferation
margin,
wound‐healing
assay.
All
all,
developed
biocompatible,
antioxidant,
Ag‐ZnO
NPs
incorporated
CS/PEO
their
potential
an
effective
dressing.
Environmental Chemistry Letters,
Год журнала:
2020,
Номер
19(1), С. 583 - 611
Опубликована: Сен. 16, 2020
Abstract
The
inert
nature
of
most
commercial
polymers
and
nanomaterials
results
in
limitations
applications
various
industrial
fields.
This
can
be
solved
by
surface
modifications
to
improve
physicochemical
biological
properties,
such
as
adhesion,
printability,
wetting
biocompatibility.
Polymer
functionalization
allows
graft
specific
moieties
conjugate
molecules
that
material
performances.
In
the
last
decades,
several
approaches
have
been
designed
industry
academia
functional
groups
on
surfaces.
Here,
we
review
decoration
nanomaterials,
with
focus
major
medical
field,
textile
industry,
water
treatment
food
packaging.
We
discuss
advantages
challenges
polymer
functionalization.
More
knowledge
is
needed
biology
behind
cell–polymer
interactions,
nanosafety
manufacturing
at
scale.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Март 19, 2022
Clinical
work
and
research
on
diabetic
wound
repair
remain
challenging
globally.
Although
various
conventional
dressings
have
been
continuously
developed,
the
efficacy
is
unsatisfactory.
The
effect
of
drug
delivery
limited
by
depth
penetration.
sustained
release
biomolecules
from
biological
a
promising
treatment
approach
to
healing.
An
assortment
cell-derived
exosomes
(exos)
proved
be
instrumental
in
tissue
regeneration,
researchers
are
dedicated
developing
carriers
with
unique
properties.
Herein,
we
reported
methacrylate
gelatin
(GelMA)
microneedles
(MNs)
patch
achieve
transdermal
controlled
exos
tazarotene.
Our
MNs
comprising
GelMA/PEGDA
hydrogel
has
distinctive
features
that
maintain
activity
drugs
vitro.
Additionally,
its
physical
structure
prevents
it
being
tightly
attached
skin
wound,
promotes
cell
migration,
angiogenesis
slowly
releasing
tazarotene
deep
layer
skin.
full-thickness
cutaneous
mouse
model
was
carried
out
demonstrate
therapeutic
effects
GelMA/PEGDA@T
+
patch.
As
result,
our
presents
potentially
valuable
method
for
repairing
clinical
applications.
