Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
infiltration
of
synovial
M1
macrophages,
high
levels
ROS,
and
NO
exacerbate
osteoarthritis
(OA)
progression.
The
PdZn/Co
SA
‐NC
nanozymes,
which
are
highly
ordered
PdZn
intermetallic
nanoparticles
loaded
with
Co
single
atom
N‐doped
carbon‐rich
in
multi‐level
pores,
an
attempt
to
serve
as
SOD
CAT
mimicking
nanozymes
for
OA
therapy
is
designed.
nanozymes'
electron
transfer
dual
active
site
sufficient
exposure
enhances
free
radical
adsorption
lower
reaction
energies,
accelerating
SOD‐like,
CAT‐like,
GPx‐like
catalyzed
reactions,
outperforming
PdZn/NC
alone.
Furthermore,
exhibit
favorable
biocompatibility,
reduce
macrophage
oxidative
stress
OA,
alleviate
hypoxia,
restore
mitochondrial
function,
regulate
energy
metabolism,
increase
antioxidant
factors,
inflammatory
thus
effectively
mitigating
the
progression
OA.
Mechanistically,
downregulate
M1‐type
phenotypic
markers
like
IL‐1β
by
regulating
purine
metabolism.
offer
a
novel
approach
treating
stress‐related
diseases.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(11)
Опубликована: Фев. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июль 15, 2024
Macrophage
immunotherapy
represents
an
emerging
therapeutic
approach
aimed
at
modulating
the
immune
response
to
alleviate
disease
symptoms.
Nanomaterials
(NMs)
have
been
engineered
monitor
macrophage
metabolism,
enabling
evaluation
of
progression
and
replication
intricate
physiological
signal
patterns.
They
achieve
this
either
directly
or
by
delivering
regulatory
signals,
thereby
mapping
phenotype
effector
functions
through
metabolic
repurposing
customize
fate
for
therapy.
However,
a
comprehensive
summary
regarding
NM-mediated
visualization
coordinated
rewiring
maintain
phenotypic
equilibrium
is
currently
lacking.
This
review
aims
address
gap
outlining
recent
advancements
in
NM-based
immunotherapy.
We
initially
explore
relationship
between
polarization,
disease,
before
delving
into
NM
innovations
that
visualize
activity
elucidate
onset
fine-tune
its
remodeling
macrophage-centered
Finally,
we
discuss
prospects
challenges
immunotherapy,
aiming
accelerate
clinical
translation.
anticipate
will
serve
as
valuable
reference
researchers
seeking
leverage
novel
intervention-matched
immunomodulators
macrophages
other
fields
engineering.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
infiltration
of
synovial
M1
macrophages,
high
levels
ROS,
and
NO
exacerbate
osteoarthritis
(OA)
progression.
The
PdZn/Co
SA
‐NC
nanozymes,
which
are
highly
ordered
PdZn
intermetallic
nanoparticles
loaded
with
Co
single
atom
N‐doped
carbon‐rich
in
multi‐level
pores,
an
attempt
to
serve
as
SOD
CAT
mimicking
nanozymes
for
OA
therapy
is
designed.
nanozymes'
electron
transfer
dual
active
site
sufficient
exposure
enhances
free
radical
adsorption
lower
reaction
energies,
accelerating
SOD‐like,
CAT‐like,
GPx‐like
catalyzed
reactions,
outperforming
PdZn/NC
alone.
Furthermore,
exhibit
favorable
biocompatibility,
reduce
macrophage
oxidative
stress
OA,
alleviate
hypoxia,
restore
mitochondrial
function,
regulate
energy
metabolism,
increase
antioxidant
factors,
inflammatory
thus
effectively
mitigating
the
progression
OA.
Mechanistically,
downregulate
M1‐type
phenotypic
markers
like
IL‐1β
by
regulating
purine
metabolism.
offer
a
novel
approach
treating
stress‐related
diseases.
