The
enzymatic
activity
of
atomically
precise
metal
nanoclusters
has
recently
been
recognized;
however,
the
number
nanoclusterzymes
is
very
small.
Besides,
applications
nanoclusterzyme
wait
to
be
explored.
Herein,
a
novel
synthesized
and
its
structure
majorly
resolved
by
single-crystal
X-ray
diffraction
mass
spectrometry,
which
reveal
that
nanocluster
consists
an
Au13
icosahedron
capped
exterior
shell
including
four
I,
three
Dppp
(1,3-bis(diphenylphosphino)
propane)
ligands,
rarely
reported
Dppp-Au-Dppp
handle
staple,
contributes
lot
enzyme
[Au14
(Dppp)5
I4
]2+
nanocluster.
as-obtained
can
catalyze
oxygen
O2•-
under
visible
light
irradiation
with
specific
up
0.182
U·mg-1
lead
blue
color
3,3',5,5'-tetramethylbenzidine
(TMB)
in
both
solution
solid
states.
With
addition
acetylcholinesterase
(AChE),
(Au14
+
TMB)
system
disappears
due
inhibition,
but
further
organophosphorus
pesticides
(OPs)
into
above
mixture
restore
recover
color.
Based
on
turn-off
on,
various
nanoclusterzyme-containing
systems
are
used
colorimetrically
sense
AChE
OPs
detection
limits
reaching
0.04
mU·mL-1
0.02
ng·mL-1
,
respectively.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Фев. 17, 2023
Abstract
Having
a
hypoxic
microenvironment
is
common
and
salient
feature
of
most
solid
tumors.
Hypoxia
has
profound
effect
on
the
biological
behavior
malignant
phenotype
cancer
cells,
mediates
effects
chemotherapy,
radiotherapy,
immunotherapy
through
complex
mechanisms,
closely
associated
with
poor
prognosis
in
various
patients.
Accumulating
studies
have
demonstrated
that
normalization
tumor
vasculature,
nanoparticle
carriers
biocarriers
can
effectively
increase
oxygen
concentration
microenvironment,
improve
drug
delivery
efficacy
radiotherapy.
They
also
infiltration
innate
adaptive
anti-tumor
immune
cells
to
enhance
immunotherapy.
Furthermore,
drugs
targeting
key
genes
hypoxia,
including
hypoxia
tracers,
hypoxia-activated
prodrugs,
hypoxia-inducible
factors
downstream
targets,
be
used
for
visualization
quantitative
analysis
antitumor
activity.
However,
relationship
between
an
area
research
requires
further
exploration.
Here,
we
investigated
potential
development
cancer,
changes
signaling
pathways
occur
adapt
environments,
mechanisms
hypoxia-induced
tolerance,
chemotherapeutic
enhanced
radiation
as
well
insights
applications
therapy.
Abstract
Hypoxia
is
a
persistent
physiological
feature
of
many
different
solid
tumors
and
key
driver
malignancy,
in
recent
years,
it
has
been
recognized
as
an
important
target
for
cancer
therapy.
occurs
the
majority
due
to
poor
vascular
oxygen
supply
that
not
sufficient
meet
needs
rapidly
proliferating
cells.
A
hypoxic
tumor
microenvironment
(TME)
can
reduce
effectiveness
other
therapies,
such
radiotherapy,
chemotherapy,
immunotherapy.
In
this
review,
we
discuss
critical
role
hypoxia
development,
including
metabolism,
immunity,
angiogenesis.
The
treatment
methods
TME
are
summarized,
hypoxia‐targeted
therapy
improving
oxygenation
by
alleviating
itself.
Hyperoxia
be
used
improve
tissue
partial
pressure
relieve
hypoxia.
We
focus
on
underlying
mechanisms
hyperoxia
their
impact
current
therapies
prospects
treatment.
Chemical Science,
Год журнала:
2023,
Номер
14(16), С. 4308 - 4318
Опубликована: Янв. 1, 2023
Developing
a
high-performance
noninvasive
probe
for
precise
cancer
theranostics
is
very
challenging
but
urgently
required.
Herein,
novel
Au
nanoclusters
(NCs)-based
was
designed
via
ligand
engineering
by
conjugating
photoluminescent
(PL)
Au44
NCs
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm)
with
aromatic
photoacoustic
(PA)/photothermal
molecules
through
click
chemistry.
This
design
bypasses
incompatibility
dilemma
between
photoluminescence
attributes
and
PA/photothermal
properties
because
rigidity
of
can
lead
to
aggregation-induced
emission
(AIE)
Au(i)-ligand
shell
constraining
their
nonradiative
relaxation.
Benefiting
from
strong
NIR-II
PL
emissions
at
1080
1240
nm,
high
photothermal
conversion
efficiency
(65.12%),
low
cytotoxicity,
appropriate
renal
clearance,
enhanced
permeability
retention
(EPR)
effect,
as-designed
NC-based
theranostic
achieves
ultradeep
PL/PA
imaging-guided
therapy
(PTT).
Remarkably,
16
days
after
treatment
guided
imaging,
mice
were
all
healed
without
tumor
recurrence,
while
average
life
span
control
groups
only
17-21
days.
study
interesting
it
provides
paradigm
designing
metal
probe,
may
add
fundamentally
methodologically
disease
therapy.
Abstract
The
immunological
implications
of
cuproptosis,
a
form
cell
death
highly
sensitive
to
oxygen
presence,
remain
largely
unexplored
in
the
context
tumor
immunotherapy.
Herein,
we
initially
investigate
positive
correlation
between
cuproptosis
and
immunotherapy
through
bioinformatics
analysis.
Subsequently,
an
generator
loaded
with
copper
ions
(
Cu/AP
H‐M)
has
been
constructed,
which
serves
as
effective
carrier
crucially
enhances
oxygenation
microenvironment.
Importantly,
H‐M‐mediated
dual
strengthening
radiotherapy
could
not
only
trigger
powerful
antitumor
immunity
related
immunogenic
by
RNA‐sequencing
analysis,
but
also
effectively
inhibit
growth
both
distal
situ
low
rectal
tumors
after
combined
immunotherapy,
creating
robust
immune
memory
effect.
Our
work
reveals
beneficial
effects
enhanced
radio‐immunotherapy
elucidates
its
underlying
mechanisms,
provides
novel
approach
for
synergistic
integration
radiotherapy,
broadening
scope
cuproptosis‐mediated
therapy.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Фев. 15, 2023
Radiation
therapy
is
an
important
component
of
cancer
treatment.
As
research
in
radiotherapy
techniques
advances,
new
methods
to
enhance
tumor
response
radiation
need
be
on
the
agenda
enable
enhanced
at
low
doses.
With
rapid
development
nanotechnology
and
nanomedicine,
use
nanomaterials
as
radiosensitizers
overcome
resistance
has
attracted
great
interest.
The
application
emerging
biomedical
field
offers
good
opportunities
improve
efficacy
radiotherapy,
which
helps
promote
will
applied
clinical
practice
near
future.
In
this
paper,
we
discuss
main
types
nano-radiosensitizers
explore
their
sensitization
mechanisms
tissue
level,
cellular
level
even
molecular
biology
genetic
analyze
current
status
promising
provide
outlook
future
applications.
Abstract
The
management
of
infected
wounds
is
always
great
significance
and
urgency
in
clinical
biomedical
fields.
Recent
efforts
this
area
are
focusing
on
the
development
functional
wound
patches
with
effective
antibacterial,
drug
delivery,
sensor
properties.
Here,
we
present
novel
hyaluronic
acid
(HA)
microneedle
these
features
by
encapsulating
aminobenzeneboronic
acid‐modified
gold
nanoclusters
(A‐GNCs)
for
management.
A‐GNCs
loaded
were
derived
from
negative‐mold
replication
showed
high
mechanical
strength
to
penetrate
skin.
release
was
realized
degradation
HA,
self‐monitor
released
actives
based
dynamic
bright
orange
fluorescence
emitted
under
ultraviolet
radiation.
As
could
destroy
bacteria
membranes,
excellent
vitro
antibiosis
ability.
Based
features,
have
demonstrated
inhibition,
residual
self‐monitoring,
healing
promotion
abilities
Escherichia
coli‐
or
Staphylococcus
aureus
‐infected
These
results
indicated
potential
such
applications.
Nano Letters,
Год журнала:
2024,
Номер
24(12), С. 3801 - 3810
Опубликована: Март 13, 2024
The
effectiveness
of
various
cancer
therapies
for
solid
tumors
is
substantially
limited
by
the
highly
hypoxic
tumor
microenvironment
(TME).
Here,
a
microalgae-integrated
living
hydrogel
(ACG
gel)
developed
to
concurrently
enhance
hypoxia-constrained
starvation
therapy
and
immunotherapy.
ACG
gel
formed
in
situ
following
intratumoral
injection
biohybrid
fluid
composed
alginate,
Chlorella
sorokiniana,
glucose
oxidase,
facilitated
crossing-linking
between
divalent
ions
within
alginate.
microalgae
sorokiniana
embedded
generate
abundant
oxygen
through
photosynthesis,
enhancing
oxidase-catalyzed
consumption
shifting
TME
from
immunosuppressive
immunopermissive
status,
thus
reducing
cell
energy
supply
boosting
antitumor
immunity.
In
murine
4T1
models,
significantly
suppresses
growth
effectively
prevents
postoperative
recurrence.
This
study,
leveraging
as
natural
oxygenerators,
provides
versatile
universal
strategy
development
oxygen-dependent
therapies.
Nanoscale,
Год журнала:
2024,
Номер
16(17), С. 8196 - 8215
Опубликована: Янв. 1, 2024
This
review
delves
into
enzyme-mimic
catalysis
of
metal
nanoclusters
based
on
a
hierarchical
structure
scheme
reminiscent
proteins.
Biomedical
applications
established
by
the
clusters
have
also
been
outlined.
