Energy storage materials, Год журнала: 2025, Номер unknown, С. 104220 - 104220
Опубликована: Март 1, 2025
Язык: Английский
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июнь 13, 2023
Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.
Язык: Английский
Процитировано
119
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 231, С. 123354 - 123354
Опубликована: Янв. 18, 2023
Язык: Английский
Процитировано
102
Cell Reports Physical Science, Год журнала: 2024, Номер 5(7), С. 102097 - 102097
Опубликована: Июль 1, 2024
The rapid development of intelligent devices imposes new demands on electromagnetic wave (EMW)-absorbing materials, especially concerning wide-spectrum absorption, frequency band manipulation, and multifunctional integration. However, conventional investigations EMW-absorbing materials face several challenges that collectively limit the effectiveness existing amid growing demands, including ambiguous (EM) loss mechanisms, impedance mismatches, deficiencies in integrated design. This review elucidates EM delineates key bridge mechanisms linking microscopic macroscopic factors, proposes dielectric polarization models to clarify mechanisms. Additionally, it delves into unique advantages core-shell structures porous optimization. Finally, introduces fabrication approaches integrate detailing design strategies exploring potential applications. By consolidating these cutting-edge achievements, this aims guide scientific advancement materials.
Язык: Английский
Процитировано
61
Advanced Materials, Год журнала: 2023, Номер 36(7)
Опубликована: Ноя. 10, 2023
Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) ultrafine size palladium nanoparticles broadband near infrared absorption exhibit excellent oxidase-like activity stable photothermal effect. In vitro experiments demonstrate that the superoxide radical generated SLS-Pd exhibits selective antibacterial effects, while its effect induced hyperthermia potent antifungal properties. This difference further elucidated RNA-sequencing analysis all-atom simulation. Moreover, SLS-Pd-mediated synergistic antimicrobial system remarkable efficacy in combating various biofilms. By establishing root canal model oropharyngeal candidiasis model, feasibility treating biofilm-related infections validated. provides promising therapeutic approach for biofilm-associated cavity.
Язык: Английский
Процитировано
56
Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 6, 2023
Core-shell structured nanocarriers have come into the scientific spotlight in recent years due to their intriguing properties and wide applications materials chemistry, biology, biomedicine. Tailored core-shell structures achieve desired performance emerged as a research frontier development of smart drug delivery system. However, systematic reviews on design loading/release mechanisms stimulus-responsive are uncommon. This review starts with categories different means payload, then highlights controlled release mechanism realized through stimulus-response processes triggered under environments. Finally, some multifaceted perspectives carriers addressed. work aims provide new enlightenments prospects field for further developing advanced nanocarriers.
Язык: Английский
Процитировано
55
Advanced Materials, Год журнала: 2024, Номер 36(18)
Опубликована: Янв. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Язык: Английский
Процитировано
32
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Март 19, 2024
Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.
Язык: Английский
Процитировано
27
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 6, 2025
Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, common feature solid tumor, associated with drug resistance and poor prognosis in BC. In this study, we present strategy to overcome hypoxia-induced chemotherapy tolerance Specifically, synthesized hollow gold (Au)-platinum (Pt) bimetallic nanoshell for the first time, which acted as delivery system (DDS) doxorubicin (DOX). The photothermal effect, induced by surface plasmon resonance (SPR) from Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through therapy (PTT), but also significantly enhances catalase-like activity between Pt nanoparticles endogenous H2O2. This, subsequently, results heightened yield O2, further facilitates release DOX. This process alleviates hypoxia down-regulating hypoxia-inducible factor-1α (HIF-1α), multidrug gene 1 (MDR1), P-glycoprotein (P-gp), can reverse achieve more effective DOX effects. Significantly, increased availability oxygen re-polarizes immunosuppressive M2 macrophages into antitumor M1 macrophages. study presents novel tackle proliferation enhance response chemotherapy, offering hope reversing cancerous lesions.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123159 - 123159
Опубликована: Янв. 5, 2023
Язык: Английский
Процитировано
42
Advanced Materials, Год журнала: 2023, Номер 36(3)
Опубликована: Ноя. 16, 2023
Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant
Язык: Английский
Процитировано
39