Biomaterials Science,
Год журнала:
2024,
Номер
12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 24055 - 24069
Опубликована: Дек. 4, 2023
Hydrogels
have
attracted
tremendous
attention
as
favorable
corneal
substitutes
for
treating
severe
infectious
keratitis
(IK).
However,
current
hydrogel-based
were
majorly
designed
to
promote
the
single
stage
of
regeneration,
which
falls
short
in
meeting
clinical
management
needs
IK
including
multiple
phases
wound
healing.
Herein,
we
introduce
a
versatile
hybrid
hydrogel
(SQPV)
composed
silk
fibroin
and
chitosan,
exhibits
spatiotemporal
properties
drug
release.
The
SQPV
is
fabricated
by
incorporating
verteporfin-loaded
poly(lactic-co-glycolic)-polyethylene
glycol-o-nitrobenzene
micelles
into
network,
formed
from
methacrylate
glycidyl
functionalized
quaternized
chitosan
containing
polydeoxyribonucleotide.
This
double
network
approach
results
material
with
exceptional
anti-inflammatory,
antibacterial,
proliferative
stimulation
tissue
remodeling
regulation
capabilities.
Furthermore,
showcases
mechanical
strength
transparency
akin
those
native
cornea.
Extensive
vitro
vivo
studies
validate
SQPV's
ability
effectively
eliminate
residual
bacteria,
mitigate
inflammation,
foster
regeneration
epithelium
stroma,
prevent
scarring,
ultimately
expedite
In
summary,
SF/CS-based
may
represent
promising
substitute
comprehensive
repair
IK.
Biomaterials Science,
Год журнала:
2023,
Номер
12(1), С. 8 - 56
Опубликована: Окт. 25, 2023
Hydrogels
have
established
their
significance
as
prominent
biomaterials
within
the
realm
of
biomedical
research.
However,
injectable
hydrogels
garnered
greater
attention
compared
with
conventional
counterparts
due
to
excellent
minimally
invasive
nature
and
adaptive
behavior
post-injection.
With
rapid
advancement
emerging
chemistry
deepened
understanding
biological
processes,
contemporary
been
endowed
an
"intelligent"
capacity
respond
various
endogenous/exogenous
stimuli
(such
temperature,
pH,
light
magnetic
field).
This
innovation
has
spearheaded
revolutionary
transformations
across
fields
such
tissue
engineering
repair,
controlled
drug
delivery,
disease-responsive
therapies,
beyond.
In
this
review,
we
comprehensively
expound
upon
raw
materials
(including
natural
synthetic
materials)
principles
these
advanced
hydrogels,
concurrently
providing
a
detailed
discussion
prevalent
strategies
for
conferring
stimulus
responsiveness.
Finally,
elucidate
latest
applications
"smart"
stimuli-responsive
in
domain,
offering
insights
into
prospects.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100741 - 100741
Опубликована: Июль 20, 2023
Treatment
of
large
bone
defects
represents
a
great
challenge
in
orthopedic
and
craniomaxillofacial
surgery.
Traditional
strategies
tissue
engineering
have
focused
primarily
on
mimicking
the
extracellular
matrix
(ECM)
terms
structure
composition.
However,
synergistic
effects
other
cues
from
microenvironment
during
regeneration
are
often
neglected.
The
is
sophisticated
system
that
includes
physiological
(e.g.,
neighboring
cells
such
as
macrophages),
chemical
oxygen,
pH),
physical
factors
mechanics,
acoustics)
dynamically
interact
with
each
other.
Microenvironment-targeted
increasingly
recognized
crucial
for
successful
offer
promising
solutions
advancing
engineering.
This
review
provides
comprehensive
overview
current
microenvironment-targeted
challenges
further
outlines
prospective
directions
approaches
construction
organoids.
Journal of Materiomics,
Год журнала:
2023,
Номер
9(5), С. 930 - 958
Опубликована: Март 31, 2023
Over
the
last
decades,
bone
tissue
engineering
has
increasingly
become
a
research
focus
in
field
of
biomedical
engineering,
which
biomaterials
play
an
important
role
because
they
can
provide
both
biomechanical
support
and
osteogenic
microenvironment
process
regeneration.
Among
these
biomaterials,
two-dimensional
(2D)
nanomaterials
have
recently
attracted
considerable
interest
owing
to
their
fantastic
physicochemical
biological
properties
including
great
biocompatibility,
excellent
capability,
large
specific
surface
area,
outstanding
drug
loading
capacity.
In
this
review,
we
summarize
state-of-the-art
advances
2D
for
engineering.
Firstly,
introduce
most
explored
used
advantages.
We
then
highlight
cutting-edge
such
as
graphene
its
derivatives,
layered
double
hydroxides,
black
phosphorus,
transition
metal
dichalcogenides,
montmorillonite,
hexagonal
boron
nitride,
graphite
phase
carbon
carbonitrides
(MXenes)
Finally,
current
challenges
future
prospects
regeneration
clinical
translation
are
discussed.
Biomaterials Science,
Год журнала:
2024,
Номер
12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
