Twisted‐Planar Molecular Engineering with Sonication‐Induced J‐Aggregation to Design Near‐Infrared J‐Aggregates for Enhanced Phototherapy DOI
Yubo Liu,

Yuchen Song,

Zhong‐Hong Zhu

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract J‐aggregates show great promise in phototherapy, but are limited to specific molecular skeletons and poor self‐assembly controllability. Herein, we report a twisted‐planar strategy with sonication‐induced J‐aggregation develop donor–acceptor (D–A) type for phototherapy. With propeller aggregation‐induced emission (AIE) moieties as the twisted subunits thiophene planar π‐bridge, optimal π‐interaction MTSIC induces appropriate slip angle formation, redshifting absorption from 624 nm 790 nm. In contrast, shorter π‐planarity results amorphous aggregates, elongation promotes charge transfer (CT) coupled J‐aggregates. Sonication was demonstrated be effective controlling behaviors of MTSIC, which enables transformation aggregates H‐intermediates, finally stable After encapsulation lipid‐PEG, resultant J‐dots enhanced phototherapeutic effects over dots, including brightness, reactive oxygen species (ROS) generation, photothermal conversion, delivering superior cancer phototherapy performance. This work not only advances D–A design also provides promising supramolecular assembly development.

Язык: Английский

Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy DOI
Rangrang Fan,

Caili Chen,

Min Mu

и другие.

ACS Nano, Год журнала: 2023, Номер 17(10), С. 9126 - 9139

Опубликована: Апрель 25, 2023

Administration of bispecific antibodies (biAbs) in tumor therapy is limited by their short half-life and off-target toxicity. Optimized strategies or targets are needed to overcome these barriers. B7-H3 (CD276), a member the B7 superfamily, associated with poor survival glioblastoma (GBM) patients. Moreover, dimer EGCG (dEGCG) synthesized this work enhanced IFN-γ-induced ferroptosis cells vitro vivo. Herein, we prepared recombinant anti-B7-H3×CD3 biAbs constructed MMP-2-sensitive S-biAb/dEGCG@NPs offer combination treatment strategy for efficient systemic GBM elimination. Given targeted delivery microenvironment responsiveness, displayed intracranial accumulation, 4.1-, 9.5-, 12.3-fold higher than that biAb/dEGCG@NPs, biAb/dEGCG complexes, free biAbs, respectively. Furthermore, 50% GBM-bearing mice S-biAb/dEGCG@NP group survived longer 56 days. Overall, can induce elimination boosting effect enhancing immune checkpoint blockade (ICB) immunotherapy may be successful antibody nanocarriers cancer therapy.

Язык: Английский

Процитировано

57
Recent advances in near-infrared-II organic J-aggregates for bio-applications DOI

Junchao Xu,

Xudong Zheng, Tian‐Bing Ren

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 528, С. 216379 - 216379

Опубликована: Янв. 4, 2025

Язык: Английский

Процитировано

4
Multimodal optoacoustic imaging: methods and contrast materials DOI Creative Commons
Zhenyue Chen,

Irmak Gezginer,

Quanyu Zhou

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6068 - 6099

Опубликована: Янв. 1, 2024

Combining optoacoustics with other imaging techniques helps bring its powerful label-free functional readings and molecular sensitivity into precise anatomical context while providing an essential cross-validation against established methods.

Язык: Английский

Процитировано

17
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies DOI Creative Commons

X.F. Bai,

Fanliang Meng,

Xuejiao Wang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 19, 2025

Abstract Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) capable penetrating deeply into tumor tissues utilizing photodynamic-triggered explosive energy and receptor-mediated transcytosis, significantly enhancing therapeutic efficacy breast cancer. The were fabricated by loading powerful components chlorin e6 MnO 2 nanoparticles, as well Doxorubicin, crosslinked Ca 2+ -gel. Upon exposure laser irradiation, obtained are generating energy, resulting fragmentation numerous nanofragments. subsequently drives these nanofragments penetrate through gap leakage among cells. In addition, also promotes escape those (including e6, doxorubicin) from lysosomes. subsequent stages, exhibit excellent transcytosis capacity, facilitating deep tissues. As expected, enhanced accumulation can be achieved, anti-proliferation capacity against

Язык: Английский

Процитировано

2
Facilely Achieving Near-Infrared-II J-Aggregates through Molecular Bending on a Donor–Acceptor Fluorophore for High-Performance Tumor Phototheranostics DOI
Yingpeng Wan,

Yijian Gao,

Wei‐Chih Wei

и другие.

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Constructing J-aggregated organic dyes represents a promising strategy for obtaining biomedical second near-infrared (NIR-II) emissive materials, as they exhibit red-shifted spectroscopic properties upon assembly into nanoparticles (NPs) in aqueous environments. However, currently available NIR-II J-aggregates primarily rely on specific molecular backbones with intricate design strategies and are susceptible to fluorescence quenching during assembly. A facile approach constructing bright using prevalent donor-acceptor (D-A) molecules is still lacking. In this study, we present method that transforms D-A by simply bending the molecule through introducing methyl group, enabling high-performance phototheranostics. The TAA-BT-CN exhibits hypsochromic-shift absorption forming H-aggregated NPs, while designed mTAA-BT-CN bent structure demonstrates bathochromic shift of over 100 nm leading much enhanced emission beyond 1100 nm. With respect its counterpart aggregation-caused (ACQ) phenomenon, NPs 7-fold increase owing their aggregation-induced (AIE) property well efficient generation heat reactive oxygen species under 808 light excitation. Finally, employed whole-body blood vessel imaging technology imaging-guided tumor phototherapies. This study will facilitate flourishing advancement based D-A-type molecules.

Язык: Английский

Процитировано

9
Illuminating the invisible: Advancing bio-imaging and diagnosis with modified near-infrared fluorescents DOI

Liheng Lu,

Nengwen Chen,

Bo Yuan

и другие.

Applied Materials Today, Год журнала: 2024, Номер 38, С. 102210 - 102210

Опубликована: Май 14, 2024

Язык: Английский

Процитировано

4
Highly Stable Near-Infrared II Luminescent Diradicaloids for Cancer Phototheranostics DOI
Lina Feng,

Yanyan Tuo,

Zipeng Wu

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(47), С. 32582 - 32594

Опубликована: Ноя. 13, 2024

Near-infrared II (NIR-II) phototheranostic agents have become prominent for the early diagnosis and precise treatment of cancer. Organic open-shell diradicaloids with distinct structure narrow band gap are promising candidates phototherapeutic due to their strong spin-coupling effect NIR light-harvesting capacity. However, achieving stable efficient NIR-II luminescent is crucial yet rather challenging considering high chemical reactivity self-absorption. Herein, two highly diradicaloids, 2PhNVDPP PhNVDPP, were successfully fabricated by employing an acceptor planarization/π-conjugation extension donor rotation strategy. After encapsulation into water-dispersible nanoparticles (NPs), NPs exhibit luminescence, PCE 53%, improved photo/heat stability. In vivo experiments demonstrated clear visualization blood vessels tumors, as well successful imaging-guided photothermal ablation tumors. This study not only develops a pioneering diradicaloid agent luminescence but also provides unique perspective effectiveness multimodal anticancer therapy.

Язык: Английский

Процитировано

4
Facile Alkyne Assembly-Enabled Functional Au Nanosheets for Photoacoustic Imaging-Guided Photothermal/Gene Therapy of Orthotopic Glioblastoma DOI
Xixi Hu,

Peiling Li,

Dongdong Xu

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Treatment of glioblastoma (GBM) remains challenging due to the presence blood-brain barrier (BBB) and tumor heterogeneity. Herein, Au nanosheets (AuNSs) functionalized with RGD peptides small interfering RNA (siRNA), referred as AuNSs-RGD-C≡C-siRNA (ARCR), are prepared achieve multimodal therapy for GBM. The AuNSs a large modifiable surface area, intriguing photothermal conversion efficiency (50.26%), remarkable stability (44 cycles over 7 h) created using well-designed amphiphilic surfactant. Furthermore, alkynyl groups assembled onto within 1 min, enabling strong covalent binding siRNA thereby avoiding interference from biological thiols. Owing lipophilicity surfactant targeting property RGD, ARCR effectively passes through BBB accumulates in GBM regions, allowing near-infrared photoacoustic imaging-guided photothermal/gene therapy. This work proposes facile strategy construct theranostic Au-based materials, highlighting potential multifunctional nanoagents

Язык: Английский

Процитировано

4
Critical Challenges of Intravenous Nanomaterials Crossing the Blood‐Brain Barrier: from Blood to Brain DOI
Weikang Luo, Cong Chen,

Xin Guo

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract Despite recent advancements in the development of blood‐brain barrier (BBB)‐crossing nanomaterials for intravenous administration, there have been very few successful cases clinical trials. Ongoing challenges within body impede precise therapeutic effects these from reaching their intended target area. Therefore, a comprehensive analysis entire pathway that BBB‐crossing must traverse‐from bloodstream to brain‐along with an understanding obstacles encountered along way, is essential advancing materials This review begins brief overview structure and function BBB, as well pathways strategies crossing it. Next, it discussed analyzed common sites brain bloodstream. To address challenges, “eight‐step” guideline strategy proposed. By leveraging principles precision medicine, design customization cascade‐targeted can overcome multiple show promise future trials practical applications. Finally, perspective on direction this field offered.

Язык: Английский

Процитировано

4
Near‐Infrared‐II Nanomaterials for Activatable Photodiagnosis and Phototherapy DOI

Wanying Jiang,

Lisheng Lin,

Ping Wu

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 30(33)

Опубликована: Апрель 13, 2024

Near-Infrared-II (NIR-II) spans wavelengths between 1,000 to 1,700 nanometers, featuring deep tissue penetration and reduced scattering absorption characteristics, providing robust support for cancer treatment tumor imaging research. This review explores the utilization of activatable NIR-II photodiagnosis phototherapy based on microenvironments (e. g., reactive oxygen species, pH, glutathione, hypoxia) external stimulation laser, ultrasound, photothermal) precise imaging. Special emphasis is placed advancements advantages nanomedicines in novel therapeutic modalities like photodynamic therapy, photothermal photoacoustic encompasses achieving penetration, real-time monitoring process, obtaining high-resolution, high signal-to-noise ratio images even at low material concentrations. Lastly, from a clinical perspective, challenges faced by are discussed, alongside potential strategies overcome these hurdles.

Язык: Английский

Процитировано

3