Abstract
Nanozyme
activity
relies
on
surface
electron
transfer
processes.
Notably,
the
piezoelectric
effect
plays
a
vital
role
in
influencing
nanozyme
by
generating
positive
and
negative
charges
materials'
surfaces.
This
article
comprehensively
reviews
potential
mechanisms
practical
applications
of
regulating
through
effect.
The
first
elucidates
how
enables
nanozymes
to
exhibit
catalytic
activity.
It
is
highlighted
that
produced
this
directly
participate
redox
reactions,
leading
conversion
materials
from
an
inactive
active
state.
Moreover,
field
generated
can
enhance
accelerating
rates
or
reducing
binding
energy
between
substrates.
Practical
are
explored
subsequent
section,
including
water
pollutant
degradation,
bacterial
disinfection,
biological
detection,
tumor
therapy,
which
demonstrate
versatile
potentials
applications.
review
concludes
emphasizing
need
for
further
research
into
nanozymes,
suggesting
expanding
scope
types
exploring
new
application
areas.
Furthermore,
promising
direction
synergistic
therapy
discussed
as
inspiring
avenue
future
research.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Март 15, 2024
Abstract
Bacterial
infections
pose
a
major
concern
for
the
medical
community,
especially
regarding
wound
healing.
Traditional
passive
antibiotic
therapies
can
be
cytotoxic
and
lead
to
bacterial
resistance,
posing
continuing
challenge
treat.
Based
on
precision
therapy,
novel
targeted‐delivery
nanosystem
is
developed
efficiently
eliminate
bacteria
promote
bacteria‐infected
Macrophage
membranes
pre‐activated
by
Staphylococcus
aureus
(MM
Sa
)
are
prepared.
In
doing
so,
Toll‐like
receptors
(TLRs),
typical
pathogen‐associated
molecular
pattern
(PAMP),
significantly
higher
than
normal
macrophage
0
).
Subsequently,
MM
coated
onto
ultrasound‐triggered
piezocatalytic
nano‐barium
titanate
(BaTiO
3
,
BTO)
surfaces,
these
two
components
assembled
form
targeting
delivery
nanosystem,
namely
BTO@MM
.
The
in
vitro
vivo
results
demonstrate
that
biocompatible
target
infected
areas
rapidly
generate
reactive
oxygen
species
(ROS)
kill
under
ultrasound
(US)
irradiation,
as
well
accelerate
Furthermore,
prokaryotic
RNA‐seq
transcriptomics
reveals
changes
membrane
function
substance,
energy
metabolism
responsible
targeted
antibacterial
ability
of
with
US.
Compared
widely
reported
unselective
agents,
this
has
potential
precise
infection
treatment
using
functions.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
Advanced Materials,
Год журнала:
2024,
Номер
36(18)
Опубликована: Фев. 1, 2024
Abstract
Relieving
inflammation
via
scavenging
toxic
reactive
oxygen
species
(ROS)
during
the
acute
phase
of
spinal
cord
injury
(SCI)
proves
to
be
an
effective
strategy
mitigate
secondary
and
improve
recovery
motor
function.
However,
commonly
used
corticosteroid
anti‐inflammatory
drugs
show
adverse
side
effects
which
may
induce
increased
risk
wound
infection.
Fortunately,
hydrogen
(H
2
),
featuring
selective
antioxidant
performance,
easy
penetrability,
excellent
biosafety,
is
being
extensively
investigated
as
a
potential
therapeutic
gas
for
treatment
SCI.
In
this
work,
by
facile
in
situ
growth
approach
gold
nanoparticles
(AuNPs)
on
piezoelectric
BaTiO
3
,
particulate
nanocomposite
with
Schottky
heterojunction
(Au@BT)
synthesized,
can
generate
H
continuously
catalyzing
+
reduction
through
catalysis.
Further,
theoretical
calculations
are
employed
reveal
catalytic
mechanism
Au@BT.
Transcriptomics
analysis
nontargeted
large‐scale
metabolomic
deeper
neuroprotective
effect
therapy.
The
as‐prepared
Au@BT
nanoparticle
first
explored
flexible
generator
efficient
SCI
This
study
highlights
promising
prospect
nanocatalytic
medicine
disease
treatments
generation;
thus,
offering
significant
alternative
conventional
approaches
against
refractory
injury.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(21)
Опубликована: Янв. 30, 2024
Abstract
Rescuing
dental
implants
from
plaque‐induced
infection
and
implementing
effective
plaque
control
methods
in
a
limited
oral
environment
pose
challenges
for
modern
dentistry.
To
address
this
issue,
Al
ion
doped
strontium
titanate/titanium
dioxide
nanotubes
(Al‐SrTiO
3
/TiO
2
nanotubes,
Al‐STNT)
are
designed
as
an
ultrasound‐responsive
nanocoating
immobilized
on
the
Ti
implant
surface.
Introducing
3+
ions
into
inorganic
sonosensitive
SrTiO
heterojunction
induces
oxygen
vacancies
disrupts
lattice
of
.
By
overcoming
bandgap
barrier
through
ultrasonic
stimulated
piezoelectric
effect,
Al‐STNT
produces
more
reactive
species
(ROS).
In
sonodynamic
therapy
(SDT)
process,
stimulus
abundant
ROS
efficiently
disrupting
bacteria
biofilm
inhibiting
metabolism.
Moreover,
specific
nanoscale
coating
endows
with
osteogenic
activity,
facilitating
formation
rigid
osseointegration
between
surface
alveolar
bone.
mimicking
human
rats,
demonstrates
optimal
postimplant
while
retaining
its
antibacterial
ability
sonosensitizer.
Thanks
to
portability
ultrasound
instrument
stability
implant‐based
sonosensitizer,
strategy
presents
attractive
option
patients
self‐treat
secure
long‐term
success
their
implants.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Abstract
Although
immunogenic
cell
death
(ICD)
inducers
evidently
enhance
the
effectiveness
of
immunotherapy,
their
potential
is
increasingly
restricted
by
development
apoptosis
resistance
in
tumor
cells,
poor
immunogenicity,
and
low
T‐cell
immune
responsiveness.
In
this
study,
for
first
time,
piezoelectrically
catalyzed
Mg
2+
‐doped
hydroxyapatite
(Mg‐HAP)
nanoparticles,
which
are
coated
with
a
mesoporous
silica
layer
loaded
ONC201
as
an
agonist
to
specifically
target
receptor
DR5
on
ultimately
developing
Mg‐HAP@MS/ONC201
nanoparticle
(MHMO
NP)
system,
engineered.
Owing
its
excellent
piezoelectric
properties,
MHMO
facilitates
release
significant
amount
reactive
oxygen
species
Ca
within
effectively
promoting
upregulation
expression
inducing
necroptosis
overcome
resistance.
Concurrently,
released
microenvironment
promotes
CD8
+
T
activation
response
antitumor
reaction
induced
ICD.
Using
RNA‐seq
analysis,
it
elucidated
that
can
activate
NF‐κB
pathway
under
catalysis,
thus
M1‐type
macrophage
polarization.
summary,
dual‐targeting
therapy
system
targets
both
cells
catalysis
designed.
This
holds
substantial
advancements
immunotherapy.
Antibiotic-resistant
bacteria
often
cause
lethal
infections
in
both
the
surficial
and
deep
organs
of
humans.
Failure
antibiotics
resistant
leads
to
more
effective
alternative
therapies,
like
spatiotemporally
controllable
piezodynamic
therapy
(PZDT)
with
penetration.
Currently,
PZDT
demands
further
investigation
for
improved
treatment
outcomes
corresponding
therapeutic
mechanisms.
Herein,
a
nanocomposite
cloaked
is
reported
biomimetic
coating
TLR-upregulated
macrophage
membrane
targeted
against
MRSA-induced
skin
wound
infection
osteomyelitis,
representing
models,
respectively.
To
boost
efficacy,
crystal
defect
engineering
applied
by
impregnating
Fe2+
into
bismuth
oxy-iodide
nanosheets
increase
defects.
This
results
significantly
higher
piezoelectric
coefficient
than
previous
reports,
contributing
an
amplified
reactive
oxygen
species
generation
bacterial
killing.
More
importantly,
notable
effect
not
only
re-programs
macrophages
anti-inflammatory
M2
phenotype
accelerating
healing
but
also
stimulates
opening
piezo-stimulated
Ca2+
channels
boosts
differentiation
mesenchymal
stem
cells
osteoblasts
expediting
bone
tissue
repair
osteomyelitis
model.
Moreover,
Fe-doping
supplements
T2-magnetic
resonance
imaging
real-time
visualization
distribution.
theranostic
system
opens
new
avenue
future
drug-resistant
bacteria-caused
diseases.
Abstract
This
study
explores
the
role
of
S
vacancies
in
MoS
2
enhancing
its
piezocatalytic
efficiency.
Sulfur
crystal
lattice
introduce
localized
changes
electronic
structure
and
charge
distribution,
improving
material's
piezoelectric
response.
Characterization
catalysts
involved
techniques
like
field‐emission
scanning
electron
microscopy
(FESEM),
X‐ray
diffraction
(XRD),
transmission
(TEM),
photoelectron
spectroscopy
(XPS).
Electrochemical
measurements,
including
impedance
(EIS)
Mott–Schottky
(M‐S)
analysis,
are
performed
to
assess
performance.
The
also
employed
density
functional
theory
(DFT)
calculations
investigate
hydrogen
adsorption
properties
with
vacancies.
results
demonstrated
that
S‐deficient
significantly
enhanced
H
evolution.
production
rates
different
vacancy
concentrations
measured
under
ultrasonic
vibration.
sample
an
optimal
concentration
(MS‐1)
exhibited
highest
rate
1423.29
µmol
g
−1
h
,
compared
439.06
for
pristine
(MS‐0).
improved
performance
is
attributed
increased
polarization
efficient
separation
facilitated
by
