Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(30), С. 16658 - 16668

Опубликована: Июль 24, 2023

Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and self-protective mechanism cells significantly weakens therapeutic efficiency. Here, a bioorthogonal nanoregulator constructed to induce disrupt checkpoint, enabling high-efficiency The allows situ synthesis accumulation photosensitizer PpIX mitochondria directly produce mitochondrial ROS, thus triggering pyroptosis. Meanwhile, generated inhibitor via palladium-catalyzed chemistry can boost efficacy. With biomimetic membrane coating, this platform for modulating presents specificity poses no harm normal tissue, resulting highly efficient safe antitumor treatment. To our knowledge, first report on disrupting intrinsic protective tumor This work highlights plays key regulative role therapy, which would motivate future design regimens.

Язык: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Год журнала: 2024, Номер 11(16)

Опубликована: Фев. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Язык: Английский

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Catalytic Biomaterials

Accounts of Materials Research, Год журнала: 2024, Номер 5(3), С. 271 - 285

Опубликована: Фев. 16, 2024

ConspectusCatalytic biomaterials, an emerging frontier in biomaterials research, offer tremendous potential to circumvent the limitations of traditional treatment approaches, such as low specificity and adverse effects. By harnessing intrinsic physicochemical properties materials, catalytic especially nanoscale (termed nanomedicine), can directly engage with a range biogenic substrates initiate various chemical or biochemical reactions vivo. Chemically designed nanozymes emulate endogenous enzymes regulating intracellular redox homeostasis, offering distinct advantages over their natural counterparts, design flexibility, adjustable functionalities, robust stability harsh conditions, cost-effective production. The extensively investigated mimicked by include peroxidases, oxidases, superoxide dismutases, catalase, glutathione peroxidase. To improve enzyme-mimicking activities properties, composition, size, morphology, exposed crystal facets, surface chemistry, are finely tuned for reactive oxygen species (ROS)-producing pro-oxidative ROS-eliminating antioxidative applications. As interdisciplinary research catalysis biomedicine deepens, cutting-edge concepts catalysis, including single-atom photocatalysis, electrocatalysis, piezoelectric thermoelectric have gradually merged biomaterials. resultant be activated spatiotemporally light, ultrasound, magnetic fields, heat, etc., beyond scope aforementioned endogenously responsive nanozymes. Given semiconductor nature these externally defect engineering heterojunction strategies utilized enhance separation suppress recombination electron–hole pairs modulating bandgap structures. Consequently, efficacy rationally engineered generating scavenging ROS profoundly improved. Apart from ROS-centered applications, content has also been extended transformation substrates, depletion, glucose/lactate consumption, gas production inorganic nanocatalysts. Collectively, which purposefully influence cellular homeostasis regulate cell signaling pathways, assumed play pivotal role addressing spectrum pathophysiological disorders associated oxidative stress dysfunctions, cancer, inflammation, immunomodulation, neurodegeneration, cardiovascular diseases. connections among nanomedicine, nanozymes, we present our insights here clarify distinctions. Catalytic broader scope, spanning nanoscale, microscale, macroscale that possess specific activities. involved encompass both enzyme-mimetic well endogenously/exogenously initiated nanomedicine emphasizes integration nanotechnology therapeutic Nanozymes specifically focus on nanomaterials. Thus, utilize term "catalytic biomaterials" describe this fast-evolving field anticipate will motivate deeper between materials science, medicine.In Account, provide concise introduction fundamental understanding categorizing them into three groups based action mechanisms. Then, highlight group's work fabrication diverse biomedical cancer therapy, antibacterial, anti-inflammation, tissue engineering, regenerative medicine Our primary is deliberate tailor-made application sophisticated scenarios. biological effects arising elucidated. Furthermore, perspectives clinical translation discussed. We envision rapid development could spur evolution highly effective therapeutic/regenerative approaches minimal toxicity wide medical conditions.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Topochemical-like bandgap regulation engineering: A bismuth thiooxide nanocatalyst for breast cancer phototherapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 171 - 182

Опубликована: Фев. 8, 2024

Язык: Английский

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Enzyme-Mediated Bioorthogonal Cascade Catalytic Reaction for Metabolism Intervention and Enhanced Ferroptosis on Neuroblastoma

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(12), С. 8228 - 8241

Опубликована: Март 12, 2024

It remains a tremendous challenge to explore effective therapeutic modalities against neuroblastoma, lethal cancer of the sympathetic nervous system with poor prognosis and disappointing treatment outcomes. Considering limitations conventional intrinsic vulnerability we herein develop pioneering sequential catalytic that utilizes lactate oxidase (LOx)/horseradish peroxidase (HRP)-loaded amorphous zinc metal–organic framework, named LOx/HRP-aZIF, in combination 3-indole-acetic acid (IAA) prodrug. On basis abnormal accumulation occurs tumor microenvironment, cascade reaction LOx HRP consumes endogenous glutathione reduced form nicotinamide adenine dinucleotide achieve first stage killing cells via antioxidative incapacitation electron transport chain interference. Furthermore, generation reactive oxygen species induced by IAA through bioorthogonal catalysis promotes ferritin degradation lipid peroxidation, ultimately provoking self-enhanced ferroptosis positive feedback initiating an Fenton reaction. This work highlights superiority natural enzyme-dependent reaction, offering paradigm for synergistically enzyme-based metabolism-ferroptosis anticancer therapy.

Язык: Английский

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Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization

Advanced Science, Год журнала: 2024, Номер 11(41)

Опубликована: Авг. 19, 2024

Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.

Язык: Английский

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Ultrasound‐Triggered Cascade Amplification of Nanotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Май 24, 2023

Abstract Ultrasound (US)‐triggered cascade amplification of nanotherapies has attracted considerable attention as an effective strategy for cancer treatment. With the remarkable advances in materials chemistry and nanotechnology, a large number well‐designed nanosystems have emerged that incorporate presupposed processes can be activated to trigger therapies such chemotherapy, immunotherapy, ferroptosis, under exogenous US stimulation or specific substances generated by actuation, maximize antitumor efficacy minimize detrimental effects. Therefore, summarizing corresponding applications based on US‐triggered is essential. This review comprehensively summarizes highlights recent design intelligent modalities, consisting unique components, distinctive properties, processes. These ingenious strategies confer unparalleled potential ultrasound‐triggered provide superior controllability, thus overcoming unmet requirements precision medicine personalized Finally, challenges prospects this emerging are discussed it expected encourage more innovative ideas promote their further development.

Язык: Английский

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Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 2, 2024

Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability penetrate deep tissue with spatial temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical chemical effects ultrasonication for controlled activation prodrugs. In polymer mechanochemistry, materials scientists exploit sonomechanical effect acoustic cavitation mechanochemically activate force-sensitive On other hand, researchers sonodynamic therapy adopt fundamentally distinct methodologies, utilizing sonochemical (e.g., generation reactive oxygen species) ultrasound presence sonosensitizers induce transformations that This cross-disciplinary review comprehensively examines these two divergent yet interrelated approaches, both which originated from cavitation. It highlights molecular design strategies potential diverse therapeutic contexts, chemotherapy immunotherapy gene methods, discusses future directions this rapidly advancing domain.

Язык: Английский

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