Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
NIR-II
fluorescent
photosensitizers
as
phototheranostic
agents
hold
considerable
promise
in
the
application
of
mild
photothermal
therapy
(MPTT)
for
tumors,
reactive
oxygen
species
generated
during
photodynamic
can
effectively
disrupt
heat
shock
proteins.
Nevertheless,
exclusive
utilization
these
to
significantly
augment
MPTT
efficacy
has
rarely
been
substantiated,
primarily
due
their
insufficient
performance.
Herein,
high-performance
type
I/II
photosensitizer
(AS2
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(4)
Published: Sept. 19, 2023
Abstract
Enzymes
are
highly
efficient
catalysts
employed
in
the
biomedical
field.
However,
their
use
is
limited
by
poor
stability
and
high
cost.
To
address
this,
there
an
imperative
need
for
research
on
nanozymes.
In
last
decade,
introduction
of
nanozymes
has
led
to
exponential
growth
nanozyme‐based
biosensors.
The
rapid
precise
detection
clinical
biomarkers
crucial
various
disease
diagnostics.
recent
years,
researchers
have
developed
different
catalytic
active
nanomaterials
combined
them
with
colorimetric,
fluorescent,
electrochemical
methods
detect
biomarkers.
This
review
critically
overviews
progress,
future
prospects,
challenges
biomarker
assays
past
few
years.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(48)
Published: July 21, 2023
Abstract
Single‐atom
nanozymes
(SAzymes)
are
considered
as
the
most
promising
candidates
for
natural
enzymes
due
to
their
atomically
dispersed
active
sites
that
closely
resemble
metal
centers
of
counterparts.
However,
a
significant
challenge
still
exists
improving
catalytic
activities,
retarding
practical
applications.
Herein,
this
article
presents
through
application
human
self‐driven
triboelectric
device
impose
electrical
stimulus,
multiple
enzyme‐like
activities
single‐atom
copper
nanozyme
(Cu‐NC)
remarkably
improved,
thereby
boosting
cancer
cell
oxidative
damage
and
death
realizing
improved
therapy.
Under
an
stimulus
with
20
V
voltage,
peroxidase,
catalase,
oxidase,
glutathione
oxidase
like
Cu‐NC
all
boost
generation
free
radicals.
Through
calculation,
work
analyzes
how
modulates
activity
via
decreasing
adsorption
energy
H
2
O
on
Cu
sites,
increasing
d
xy
orbital
near
Fermi
level,
shifting
d‐band
center
Cu,
facilitating
reactions.
This
opens
new
perspectives
nanoenzymes
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(9), P. 3577 - 3599
Published: Aug. 17, 2023
Nanozymes
are
nanoparticles
with
intrinsic
enzyme-mimicking
properties
that
have
become
more
prevalent
because
of
their
ability
to
outperform
conventional
enzymes
by
overcoming
drawbacks
related
stability,
cost,
and
storage.
the
potential
manipulate
active
sites
natural
enzymes,
which
is
why
they
considered
promising
candidates
function
as
enzyme
mimetics.
Several
microscopy-
spectroscopy-based
techniques
been
used
for
characterization
nanozymes.
To
date,
a
wide
range
nanozymes,
including
catalase,
oxidase,
peroxidase,
superoxide
dismutase,
designed
effectively
mimic
enzymes.
The
activity
nanozymes
can
be
controlled
regulating
structural
morphological
aspects
multifaceted
benefits,
exploited
on
large
scale
application
in
biomedical
sector.
versatility
aids
monitoring
treating
cancer,
other
neurodegenerative
diseases,
metabolic
disorders.
Due
compelling
advantages
significant
research
advancements
made
this
area.
Although
act
potent
mimetics
specificities
suboptimal,
there
still
room
diversification
analytical
purposes.
Designing
diverse
nanozyme
systems
sensitive
one
or
substrates
through
specialized
has
subject
an
in-depth
study.
Hence,
we
believe
stimuli-responsive
may
open
avenues
diagnosis
treatment
fusing
catalytic
nanomaterial
systems.
