ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(14), P. 17313 - 17322
Published: March 27, 2024
Glucose
oxidase
(Gox)-mediated
starvation
therapy
offers
a
prospective
advantage
for
malignancy
treatment
by
interrupting
the
glucose
supply
to
neoplastic
cells.
However,
negative
charge
of
Gox
surface
hinders
its
enrichment
in
tumor
tissues.
Furthermore,
Gox-mediated
infiltrates
large
amounts
hydrogen
peroxide
(H2O2)
surround
normal
tissues
and
exacerbate
intracellular
hypoxia.
In
this
study,
cascade-catalyzed
nanogel
(A-NE)
was
developed
boost
antitumor
effects
consumption
cascade
reactive
release
nitric
oxide
(NO)
relieve
First,
cross-linking
structure
A-NE
can
serve
as
bioimmobilization
Gox,
ensuring
stability
while
improving
encapsulation
efficiency.
Then,
efficiently
inhibited
proliferation
cells
generating
H2O2.
addition,
covalent
l-arginine
(l-Arg)
consumed
H2O2
derived
from
decomposition
generate
NO,
which
augmented
on
metastatic
tumors
alleviating
Eventually,
both
vivo
vitro
studies
indicated
that
nanogels
remarkably
situ
growth
hindered
recurrence,
offering
an
alternative
possibility
clinical
intervention.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(4)
Published: Sept. 19, 2023
Abstract
Enzymes
are
highly
efficient
catalysts
employed
in
the
biomedical
field.
However,
their
use
is
limited
by
poor
stability
and
high
cost.
To
address
this,
there
an
imperative
need
for
research
on
nanozymes.
In
last
decade,
introduction
of
nanozymes
has
led
to
exponential
growth
nanozyme‐based
biosensors.
The
rapid
precise
detection
clinical
biomarkers
crucial
various
disease
diagnostics.
recent
years,
researchers
have
developed
different
catalytic
active
nanomaterials
combined
them
with
colorimetric,
fluorescent,
electrochemical
methods
detect
biomarkers.
This
review
critically
overviews
progress,
future
prospects,
challenges
biomarker
assays
past
few
years.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(48)
Published: July 21, 2023
Abstract
Single‐atom
nanozymes
(SAzymes)
are
considered
as
the
most
promising
candidates
for
natural
enzymes
due
to
their
atomically
dispersed
active
sites
that
closely
resemble
metal
centers
of
counterparts.
However,
a
significant
challenge
still
exists
improving
catalytic
activities,
retarding
practical
applications.
Herein,
this
article
presents
through
application
human
self‐driven
triboelectric
device
impose
electrical
stimulus,
multiple
enzyme‐like
activities
single‐atom
copper
nanozyme
(Cu‐NC)
remarkably
improved,
thereby
boosting
cancer
cell
oxidative
damage
and
death
realizing
improved
therapy.
Under
an
stimulus
with
20
V
voltage,
peroxidase,
catalase,
oxidase,
glutathione
oxidase
like
Cu‐NC
all
boost
generation
free
radicals.
Through
calculation,
work
analyzes
how
modulates
activity
via
decreasing
adsorption
energy
H
2
O
on
Cu
sites,
increasing
d
xy
orbital
near
Fermi
level,
shifting
d‐band
center
Cu,
facilitating
reactions.
This
opens
new
perspectives
nanoenzymes
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
