Bridging OER Electrocatalysis and Tumor Therapy: Utilizing Piezoelectric‐Hole‐Induced OER Electrocatalysis for Direct Oxygen Generation to Address Hypoxia DOI

Shuyao Li,

Meiqi Yang, Yan Wang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

Abstract In addressing the challenge of hypoxia within tumor microenvironment (TME), a significant obstacle to effective cancer therapy, this research introduces pioneering nanozyme engineered utilize water and oxygen as reactants. Utilizing ultrasonic piezoelectricity, converts these substrates into (O 2 ) reactive species, thereby amplifying oxidative stress without relying on endogenous H O . This approach involves strategic engineering porous ZnSnO v :Mn nanosheets (named MZSO NSs), which are distinguished by oxygen‐rich vacancies enhanced piezoelectric properties. breakthrough represents initial attempt merge catalytic activities akin catalase (CAT) with electrocatalytic evolution reaction (OER), confirmed through both enzymatic reactions electrochemical voltammetric analysis. The predominant mechanism ultrasound‐augmented generation in is identified hole‐induced OER. Supporting theoretical analyses clarify synergistic impact Mn doping dynamics carriers OER process, leading notable increase efficiency. These findings highlight potential piezoelectric‐enhanced electrocatalysts alleviate TME, providing novel insights development acoustic sensitizers for treatment cancer.

Язык: Английский

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment DOI Creative Commons
Yan Wang, Xiao Zhang, Hua Yue

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 18, 2024

Abstract Two-dimensional nanomaterials (2D NMs), characterized by a large number of atoms or molecules arranged in one dimension (typically thickness) while having tiny dimensions the other two dimensions, have emerged as pivotal class materials with unique properties. Their flat and sheet-like structure imparts distinctive physical, chemical, electronic attributes, which offers several advantages biomedical applications, including enhanced surface area for efficient drug loading, surface-exposed allowing precise chemical modifications, ability to form hierarchical multilayer structures synergistic functionality. Exploring their nano-bio interfacial interactions biological components holds significant importance comprehensively systematically guiding safe applications. However, current lack in-depth analysis comprehensive understanding effects on cancer treatment motivates our ongoing efforts this field. This study provides survey recent advances utilizing 2D NMs treatment. It insights into structural characteristics, synthesis methods, modifications diverse NMs. The investigation further delves formation interfaces during vivo utilization. Notably, discusses wide array applications With potential revolutionize therapeutic strategies outcomes, are poised at forefront treatment, holding promise transformative advancements. Graphical

Язык: Английский

Процитировано

12
Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches DOI
Anshuo Li, Jiawei Yang, Yuchu He

и другие.

Nanoscale Horizons, Год журнала: 2024, Номер 9(3), С. 365 - 383

Опубликована: Янв. 1, 2024

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding supporting future drug delivery system development.

Язык: Английский

Процитировано

11
Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect DOI
Huijuan Zheng, Huimin Lin, Hao Tian

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Язык: Английский

Процитировано

11
3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review DOI
Suyun Li,

Yanbo Shan,

Jingyi Chen

и другие.

Advanced Materials Technologies, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Abstract Piezoelectric composites have received widespread attentions in the fields of biomedicine and vitro wearable devices due to their ability convert mechanical forces into charge signals. The preparation piezoelectric with complex structures through 3D printing technology can not only effectively improve output, but also enable customized therapeutic applications. This paper first introduces types reviews commonly used preparation, analyzing advantages disadvantages each technology. Then, state‐of‐the‐art biomedical applications composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, vivo biosensing sensing, are emphasized. Finally, main factors affecting printed outlooked, an in‐depth discussion on challenges toward analyzed. review is believed provide some fundamental knowledge composites.

Язык: Английский

Процитировано

10
Dynamic regulation of ferroelectric polarization using external stimuli for efficient water splitting and beyond DOI
Sundaram Chandrasekaran, Qingping Wang, Qiong Liu

и другие.

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Regulating the ferroelectric polarization in catalysts is an emerging strategy to advance water splitting reactions, with merits of high charge transfer rate, creation real active sites, and optimizing chemisorption energy.

Язык: Английский

Процитировано

1
Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism DOI Creative Commons

Pei Lin,

Ye Lu,

Jiarong Zheng

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 8, 2024

Abstract Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as hub oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels variety cellular activities. Disruption mitochondrial is common feature many diseases, including cancer, neurodegenerative conditions cardiovascular diseases. Targeting tumor cell with multifunctional nanosystems emerges promising strategy for enhancing therapeutic efficacy against cancer. review comprehensively outlines pathways metabolism, emphasizing their critical roles energy production metabolic regulation. The associations between aberrant initiation progression cancer highlighted, illustrating how these disruptions contribute oncogenesis sustainability. More importantly, innovative strategies employing nanomedicines precisely target therapy fully explored. Furthermore, key challenges future directions this field identified discussed. Collectively, provides comprehensive understanding current state potential nanomedicine targeting offering insights developing more effective therapies.

Язык: Английский

Процитировано

9
Inhibiting Mitochondrial Damage for Efficient Treatment of Cerebral Ischemia‐Reperfusion Injury Through Sequential Targeting Nanomedicine of Neuronal Mitochondria in Affected Brain Tissue DOI Open Access
Shuya Wang,

Xiaojing Shi,

Ting Xiong

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(50)

Опубликована: Ноя. 6, 2024

Abstract Oxidative stress, predominantly from neuronal mitochondrial damage and the resultant cytokine storm, is central to cerebral ischemia‐reperfusion injury (CIRI). However, delivering drugs mitochondria remains challenging due blood‐brain barrier (BBB), which impedes drug entry into affected brain tissues. This study introduces an innovative tannic acid (TA) melanin‐modified heteropolyacid nanomedicine (MHT), highly specifically eliminates reactive oxygen radicals burst efficiently reduce through a strategically designed sequential targeting strategy tissue mitochondria. TA endows MHT with ability by binding matrix proteins exposed damaged BBB outer membrane of neurons, while melanin significantly enhances antioxidant capacity MHT. Consequently, effectively inhibits apoptosis protecting reversing inflammatory immune environment deactivation cyclic GMP‐AMP synthase–stimulator interferon genes (cGAS‐STING) pathway. demonstrated strong therapeutic effect on CIRI, ultralow dose (2 mg kg −1 ) proving effective in condition. work not only new avenue CIRI therapy but also offers paradigm for treating other diseases.

Язык: Английский

Процитировано

8
Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain DOI
Yifei Yin, Peiran Zhao,

Xianyun Xu

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 24, 2024

Abstract The manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization drugs, effective physical intervention strategy remains challenging. Here, controllable internalization transient receptor potential vanilloid 1 (TRPV1) on neural cells local piezoelectric field is reported. Single‐cell‐level electric construct synthesizing BiOIO 3 nanosheets (BIONSs). Upon mild ultrasound 0.08 W cm −2 , an 15.29 µV generated BIONSs, further inducing TRPV1 in 5 min. as‐downregulated expression results reduction Ca 2+ signal spinal neuron inhibition wide range dynamic neurons, therefore effectively preventing transmission cancer‐induced bone pain (CIBP). This not only charts course CIBP alleviation, but also introduces promising nanotechnology regulating receptors, showing significant neuropathological receptor‐related diseases.

Язык: Английский

Процитировано

7
Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma DOI Creative Commons

Zayne Knight,

Amalia Ruiz, Jacobo Elíes

и другие.

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(4), С. 114 - 114

Опубликована: Март 24, 2025

Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.

Язык: Английский

Процитировано

1
Piezoelectric Ba0.85Sr0.15TiO3 Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy DOI
Yunchao Zhao, Shaobo Wang,

Shuncheng Yao

и другие.

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 15, 2023

Abstract The efficacy of sonodynamic therapy (SDT) mainly relies on the sonosensitizers, which generate reactive oxygen species (ROS) upon ultrasound (US) stimulation. However, limited availability high‐efficiency sonosensitizers hampers therapeutic effectiveness SDT as a standalone modality. In this work, robust and gas cancer platform is constructed based strontium (Sr) doped barium titanate (BST) piezoelectric nanoparticles functionalized with L‐arginine (BST@LA). doping Sr into A site ABO 3 nanocrystals not only introduces vacancies enhance intrinsic piezoelectricity, but also narrows semiconductor band gap enhances charge carrier migration, all facilitate production superoxide anion (•O 2 − ) hydroxyl radical (•OH). addition, generated ROS promotes decomposition surface‐tethered LA, enabling controlled release nitric oxide (NO) at tumor site, thereby achieving combination effect. vivo experiments exhibit remarkable suppression rate (89.5%) in 4T1 mice model, demonstrating strategy. ion vacancy engineering to improve along synergistic therapy, provides promising avenues for improving therapy.

Язык: Английский

Процитировано

16