Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(25)

Опубликована: Март 16, 2024

The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd

Язык: Английский

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A Copper/Ferrous‐Engineering Redox Homeostasis Disruptor for Cuproptosis/Ferroptosis Co‐Activated Nanocatalytic Therapy in Liver Cancer

Advanced Functional Materials, Год журнала: 2024, Номер 34(37)

Опубликована: Апрель 25, 2024

Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer indocyanine green (ICG) O 2 ‐saturated perfluorohexane (PFH), denoted as ‐PFH@CHPI nanoparticles, to induce ferroptosis. In response specific TME, CHP can synergistically catalyze Fenton reactions consume endogenous glutathione, leading accumulation of reactive oxygen species. Upon near‐infrared irradiation, ‐PFH@CHPI‐enabled photothermal effect simultaneously accelerate catalytic trigger release photodynamic therapy promote oxidative stress. Notably, be effectively activated through Cu + ‐mediated dihydrolipoamide S‐acetyltransferase aggregation Fe–S cluster protein loss. Concurrently, tilt redox balance is favorable lipid peroxidation glutathione peroxidase 4 inactivation, resulting an augmented effect. Mechanistically, stress‐boosted jointly disrupt mitochondrial metabolism, which turn exacerbates stress, thus realizing a mutually enhanced This work may provide new guidance utilizing copper/ferrous‐engineering cuproptosis/ferroptosis synergetic therapy.

Язык: Английский

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Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Язык: Английский

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Fabrication Methods, Structural, Surface Morphology and Biomedical Applications of MXene: A Review

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 47003 - 47049

Опубликована: Авг. 27, 2024

Recently, two-dimensional (2-D) layered materials have revealed outstanding properties and play a crucial role for numerous advanced applications. The emerging transition metal carbides nitrides, known as MXene with empirical formula M

Язык: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)

Опубликована: Авг. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Язык: Английский

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Activatable Janus Nanoparticles for Precise NIR‐II Bioimaging and Synergistic Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(27)

Опубликована: Фев. 25, 2024

Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.

Язык: Английский

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Sterically Twisted Mitochondria‐Targeting Photosensitizers for Augmented Near‐Infrared II Fluorescence‐Guided Photodynamic Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 11, 2024

Abstract Near‐infrared (NIR) fluorescent mitochondria‐targeting photosensitizers (PSs) hold great potential for efficient image‐guided cancer phototherapy, but it remains challenging to develop PSs concurrently integrating high‐contrast NIR‐II fluorescence imaging and therapeutic capabilities. Herein, a heptamethine cyanine (HCy) PS (termed I 2 HCy‐TPE nanoparticles (NPs)) by molecular engineering strategy combining the heavy atom effect structural distortion is reported. The iodine introduced boost intersystem crossing process, bulky tetraphenylethylene (TPE) moiety placed at meso‐position of chain creates highly distorted conformation in HCy‐TPE, theoretically verified density functional theory calculations. This synergistically promotes 1 O generation efficiency assure strong NIR emission aggregated states. Combining with intrinsic capability, NPs are able cause mitochondria‐targeted damage cells via PDT immunogenetic cell death‐triggered immune responses under laser irradiation. In vivo experiments demonstrate that biocompatible present exceptional capability bioimaging whole‐body blood vessels, exert fluorescence‐guided photodynamic immunotherapy against triple‐negative breast cancer.

Язык: Английский

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Seeding Co Atoms on Size Effect‐Enabled V₂C MXene for Kinetically Boosted Lithium–Sulfur Batteries

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Lithium‐sulfur (Li–S) batteries are facing a multitude of challenges, mainly pertaining to the sluggish sulfur redox kinetics and rampant lithium dendrite growth on cathode anode side, respectively. In this sense, MXene has shown conspicuous advantages in serving as dual‐functional promotor for Li–S throughout morphologic engineering, but still suffers from poor electrocatalytic activity insufficient lithophilic sites. Herein, atomically dispersed Co sites seeded onto size effect‐enabled V 2 C spheres (Co‐VC), leading generation unique coordination configurations rich active Electrochemical tests combined with synchrotron radiation X‐ray 3D nano‐computed tomography theoretical calculations unravel that Co‐VC optimal environments simultaneously boost reaction nucleation. As consequence, modified separator can sustain stable operation over 700 cycles negligible capacity decay at 1.0 C, delivers an areal 9.0 mAh cm −2 desired cyclic performance high loading 7.6 mg lean electrolyte dosage 4.0 µL S −1 0.1 C. The work opens new avenue boosting atomic‐scale site design aid 2D substrates toward pragmatic batteries.

Язык: Английский

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Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition

Advanced Materials, Год журнала: 2024, Номер 36(45)

Опубликована: Сен. 3, 2024

Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form inflammatory programmed cell death, presents dependable strategy combating cancer by engaging multiple death pathways (apoptosis, pyroptosis, necroptosis). In this study, ultrasmall Bi 2 Sn O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties designed engineered as PANoptosis inducer through destroying mitochondrial function tumor cells enhancing intracellular accumulation toxic reactive oxygen species, finally triggering activation process. The role has been verified expression related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, 1, p‐MLKL, RIPK3. inclusion external ultrasonic irradiation significantly augments enzyodynamic efficiency. vitro in vivo antineoplastic efficacy, along inhibition lung metastasis, validate benefits ‐mediated pathway. This study not only elucidates intricate mechanisms underlying inducer, but also offers novel perspective treatment carcinoma.

Язык: Английский

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Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy

Materials Today Chemistry, Год журнала: 2024, Номер 43, С. 102455 - 102455

Опубликована: Дек. 10, 2024

Язык: Английский

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