Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Tunable Ion-Release Biodegradable Nanoparticles Enhanced Pyroptosis for Tumor Immunotherapy

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123111 - 123111

Published: Jan. 15, 2025

Language: Английский

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NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122570 - 122570

Published: April 15, 2024

Language: Английский

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Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 15, 2024

Normal life requires cell division to produce new cells, but death is necessary maintain balance. Dysregulation of can lead the survival and proliferation abnormal promoting tumor development. Unlike apoptosis, necrosis, autophagy, newly recognized forms regulated (RCD) cuproptosis, ferroptosis, PANoptosis provide novel therapeutic strategies for treatment. Increasing research indicates that immune cells mediated by these discovered regulate microenvironment (TME) influence effectiveness immunotherapy. This review primarily elucidates molecular mechanisms their complex effects on TME. also summarizes exploration nanoparticle applications in therapy based vivo vitro evidence derived from induction or inhibition RCD pathways.

Language: Английский

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Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(10)

Published: Jan. 10, 2024

Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC through synergistically depleting endogenous glutathione (GSH) activating STING signaling pathway, but also facilitated the delivery of model ovalbumin (OVA) into lymph nodes subsequent in DCs. Significant therapeutic-prophylactic efficacy OVA-loaded Mn-LDH (OVA/Mn-LDH) nanovaccine was determined by tumor growth inhibition mice bearing B16-OVA tumor. Our results showed OVA/Mn-LDH could be potent system development without need adjuvant. Therefore, combination GSH exhaustion pathway activation might an advisable approach promoting presentation, finally improving efficacy.

Language: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

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Ferroptosis and the tumor microenvironment

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: Nov. 30, 2024

Abstract Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since discovery in 2012, extensive research has demonstrated pivotal roles tumorigenesis, metastasis cancer therapy. The tumor microenvironment (TME) complex ecosystem comprising cells, non-cancer extracellular matrix, metabolites cytokines. Recent studies have underscored new paradigm which cells the TME, such as immune stromal also play significant regulating progression therapeutic resistance typically through complicated crosstalk with cells. Notably, this TME were partially mediated ferrotopsis-related mechanisms. This review provides comprehensive systematic summary current findings concerning ferroptosis how ferroptosis-mediated reprogramming impacts progression. Additionally, outlines various ferroptosis-related strategies aimed at targeting TME.

Language: Английский

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Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

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Engineered nano-aluminum adjuvant for cancer immunotherapy: Progress, challenges and opportunities towards preclinical/clinical application

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216109 - 216109

Published: Aug. 1, 2024

Immunotherapy is a promising strategy to inhibit the progression of solid tumors. However, current vaccine adjuvants represented by aluminum adjuvant (Alum) fail tumor antigens initiate effective T cell immunity. Despite efforts have been made optimize physical characteristics Alum, lack specific immunostimulatory functions still results in their inability effectively induce cytotoxic immune responses. Encouragingly, an iterative layered double hydroxide (LDH) nano‑aluminum (NanoAlum) re-engineered from clinical AlOOH Alum and Mg(OH)2 antacid has shown efficacy evoking both potent humoral cellular Notably, it can also serve as microenvironmental immunomodulator reshape aberrant physicochemical attributes microenvironment. Interestingly, highly flexible crystal structure chemical composition offer variety LDH-based candidates (NanoMAlum) doping with body essential nutritional metal ions (M), which show great potential amplify immunotherapy. In this review, we summarize development progress LDH NanoAlum its variants NanoMAlum for cancer By rethinking challenges that hindered preclinical/clinical application, charted research pathway based on engineered organoids accelerate applications these NanoMAlums review.

Language: Английский

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