Pyroptosis
has
garnered
increasing
interest
in
the
realm
of
cancer
immunotherapy.
Utilizing
reactive
oxygen
species
(ROS)
to
trigger
oxidative
stress
is
considered
an
effective
strategy
for
promoting
pyroptosis.
However,
existing
catalytic
nanoparticles
used
as
pyroptosis
inducers
contain
heavy
metals,
which
inevitably
cause
potential
side
effects
on
normal
tissues
due
their
high
toxicity
and
off-target
effects.
Herein,
a
labile
copper
pool-mediated
situ
inducer
was
designed
developed
using
hydrogen-bonded
organic
framework
(HOF)-based
nanoplatform
achieve
safe
robust
antitumor
The
could
target
mitochondria
elevate
Cu2+
levels
cells,
implementing
synthesis
through
formation
with
peroxidase
(POD)
superoxide
dismutase
(SOD)-mimicking
activities.
Our
results
confirmed
that
generate
ROS,
resulting
pyroptotic
cell
death.
When
combined
antiprogrammed
death
receptor
1
therapy
(αPD-1),
exhibited
excellent
capacity
tumor
models.
Meanwhile,
it
minimal
healthy
low
intracellular
concentration
cells.
Overall,
our
work
provides
development
efficient
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 8, 2024
Pyroptosis,
an
immunogenic
programmed
cell
death,
could
efficiently
activate
tumor
immunogenicity
and
reprogram
immunosuppressive
microenvironment
for
boosting
cancer
immunotherapy.
However,
the
overexpression
of
SLC7A11
promotes
glutathione
biosynthesis
maintaining
redox
balance
countering
pyroptosis.
Herein,
we
develop
intermetallics
modified
with
glucose
oxidase
(GOx)
soybean
phospholipid
(SP)
as
pyroptosis
promoters
(Pd
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 19, 2024
The
cell
membrane
is
a
crucial
component
of
cells,
protecting
their
integrity
and
stability
while
facilitating
signal
transduction
information
exchange.
Therefore,
disrupting
its
structure
or
impairing
functions
can
potentially
cause
irreversible
damage.
Presently,
the
tumor
recognized
as
promising
therapeutic
target
for
various
treatment
methods.
Given
extensive
research
focused
on
membranes,
it
both
necessary
timely
to
discuss
these
developments,
from
materials
design
specific
biomedical
applications.
This
review
covers
treatments
based
functional
targeting
membrane,
ranging
well-known
membrane-anchoring
photodynamic
therapy
recent
lysosome-targeting
chimaeras
protein
degradation.
diverse
mechanisms
are
introduced
in
following
sections:
phototherapy,
self-assembly
situ
biosynthesis
degradation
proteins
by
chimeras.
In
each
section,
we
outline
conceptual
general
derived
numerous
studies,
emphasizing
representative
examples
understand
advancements
draw
inspiration.
Finally,
some
challenges
future
directions
membrane-targeted
our
perspective.
aims
engage
multidisciplinary
readers
encourage
researchers
related
fields
advance
fundamental
theories
practical
applications
membrane-targeting
agents.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(22), С. 15251 - 15263
Опубликована: Май 23, 2024
Glioblastoma
(GBM)
poses
a
significant
therapeutic
challenge
due
to
its
invasive
nature
and
limited
drug
penetration
through
the
blood–brain
barrier
(BBB).
In
response,
here
we
present
an
innovative
biomimetic
approach
involving
development
of
genetically
engineered
exosome
nanocatalysts
(Mn@Bi2Se3@RGE-Exos)
for
efficient
GBM
therapy
via
improving
BBB
enzyme-like
catalytic
activities.
Interestingly,
photothermally
activatable
multiple
reactivity
is
observed
in
such
nanosystem.
Upon
NIR-II
light
irradiation,
Mn@Bi2Se3@RGE-Exos
are
capable
converting
hydrogen
peroxide
into
hydroxyl
radicals,
oxygen,
superoxide
providing
peroxidase
(POD),
oxidase
(OXD),
catalase
(CAT)-like
nanocatalytic
cascade.
This
consequently
leads
strong
oxidative
stresses
damage
cells.
vitro,
vivo,
proteomic
analysis
further
reveal
potential
disruption
cellular
homeostasis,
enhancement
immunological
induction
cancer
cell
ferroptosis,
showcasing
great
promise
anticancer
efficacy
against
with
favorable
biosafety
profile.
Overall,
success
this
study
provides
feasible
strategy
future
design
clinical
stimuli-responsive
medicine,
especially
context
challenging
brain
cancers
like
GBM.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(15)
Опубликована: Фев. 16, 2024
Developing
Type-I
photosensitizers
provides
an
attractive
approach
to
solve
the
dilemma
of
inadequate
efficacy
photodynamic
therapy
(PDT)
caused
by
inherent
oxygen
consumption
traditional
Type-II
PDT
and
anoxic
tumor
microenvironment.
The
challenge
for
exploration
PSs
is
facilitate
electron
transfer
ability
photosensitization
molecules
transforming
or
H
Abstract
Immunotherapy
has
recently
emerged
as
a
promising
therapeutic
modality
for
the
treatment
of
various
diseases
such
cancer,
inflammation,
autoimmune
diseases,
and
infectious
diseases.
Despite
its
potential,
immunotherapy
faces
challenges
related
to
delivery
efficiency
off‐target
toxicity
immunotherapeutic
drugs.
Nano
drug
systems
offer
improvements
in
biodistribution
release
kinetics
but
still
suffer
from
shortcomings
high
immunogenicity,
poor
penetration
across
biological
barriers,
insufficient
tissue
permeability.
Targeted
drugs
using
living
cells
become
an
emerging
strategy
that
can
take
advantage
inherent
characteristics
deal
with
defects
nano
systems.
Furthermore,
themselves
be
genetically
engineered
into
cellular
enhanced
immunotherapy.
This
review
provides
in‐depth
exploration
cell‐derived
carriers,
detailing
their
properties,
functions,
commonly
used
loading
strategies.
In
addition,
role
modified
synergistic
effects
are
also
introduced.
By
summarizing
main
advancements
limitations
field,
this
offers
insights
potential
cell‐based
address
existing
The
introduction
recent
developments
evaluation
ongoing
research
will
pave
way
optimization
widespread
adoption
nano/genetically
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Май 25, 2024
Abstract
The
vigorous
development
of
cancer
nanomedicine
has
revolutionized
traditional
oncology
medicine,
but
it
is
also
limited
by
the
continuous
mutation
cunning
cells,
leading
to
apoptosis
insensitivity
and
therapeutic
disappointment.
Inflammatory‐regulated
cell
death
(RCD),
especially
pyroptosis‐related
death,
demonstrates
huge
potential
for
sensitization
due
its
unique
biochemical
characteristics.
aim
this
research
present
a
thorough
synopsis
current
knowledge
on
pyroptosis‐associated
inflammatory
including
pyroptosis,
cuproptosis,
PANoptosis,
synergistic
function
in
nano
therapy.
Paradigm
studies
death‐mediated
apoptosis‐sensitizing
tumor
nanotherapeutics
are
introduced
detail,
coordination
mechanisms
based
nanomaterials
discussed.
In
addition,
multi‐angle
analysis
future
prospects
pyroptosis‐sensitized
various
emphasized
further
expand
application
scope
RCD.
It
believed
that
emerging
auxiliary
treatments
RCD
will
greatly
promote
progress
nanomedicine.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(15)
Опубликована: Фев. 16, 2024
Abstract
Developing
Type‐I
photosensitizers
provides
an
attractive
approach
to
solve
the
dilemma
of
inadequate
efficacy
photodynamic
therapy
(PDT)
caused
by
inherent
oxygen
consumption
traditional
Type‐II
PDT
and
anoxic
tumor
microenvironment.
The
challenge
for
exploration
PSs
is
facilitate
electron
transfer
ability
photosensitization
molecules
transforming
or
H
2
O
reactive
species
(ROS).
Herein,
we
propose
electronic
acceptor‐triggered
photoinduced
(a‐PET)
strategy
promoting
separation
electron‐hole
pairs
marriage
two
organic
semiconducting
a
non‐fullerene
scaffold‐based
photosensitizer
perylene
diimide
that
significantly
boost
pathway
produce
plentiful
ROS,
especially,
inducing
3.5‐fold
2.5‐fold
amplification
hydroxyl
(OH⋅)
superoxide
(O
−
⋅)
generation.
Systematic
mechanism
reveals
intermolecular
intramolecular
charge
after
photoirradiation
generate
competent
production
radical
ion
promote
process
theoretical
calculation
ultrafast
femtosecond
transient
absorption
(fs‐TA)
spectroscopy.
By
complementary
diagnosis
with
photoacoustic
imaging
second
near‐infrared
fluorescence
imaging,
this
as‐prepared
nanoplatform
exhibits
fabulous
photocytotoxicity
in
harsh
hypoxic
conditions
terrific
cancer
revoked
abilities
living
mice.
We
envision
work
will
broaden
insight
into
high‐efficiency
phototheranostics.
