In Situ Generation of Pyroptosis Inducer Mediated by Intracellular Labile Copper Pool for Safe and Robust Antitumor Immunotherapy DOI
Yanjie Zhang, Lu Zhang, Mengyu Sun

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Pyroptosis has garnered increasing interest in the realm of cancer immunotherapy. Utilizing reactive oxygen species (ROS) to trigger oxidative stress is considered an effective strategy for promoting pyroptosis. However, existing catalytic nanoparticles used as pyroptosis inducers contain heavy metals, which inevitably cause potential side effects on normal tissues due their high toxicity and off-target effects. Herein, a labile copper pool-mediated situ inducer was designed developed using hydrogen-bonded organic framework (HOF)-based nanoplatform achieve safe robust antitumor The could target mitochondria elevate Cu2+ levels cells, implementing synthesis through formation with peroxidase (POD) superoxide dismutase (SOD)-mimicking activities. Our results confirmed that generate ROS, resulting pyroptotic cell death. When combined antiprogrammed death receptor 1 therapy (αPD-1), exhibited excellent capacity tumor models. Meanwhile, it minimal healthy low intracellular concentration cells. Overall, our work provides development efficient

Язык: Английский

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

Процитировано

63

Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity DOI Creative Commons
Yanlin Zhu, Xinxin Wang, Lili Feng

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 8, 2024

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd

Язык: Английский

Процитировано

28

Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications DOI
Xiaofeng Wu, Jingjing Hu, Juyoung Yoon

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(18)

Опубликована: Фев. 19, 2024

The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction information exchange. Therefore, disrupting its structure or impairing functions can potentially cause irreversible damage. Presently, the tumor recognized as promising therapeutic target for various treatment methods. Given extensive research focused on membranes, it both necessary timely to discuss these developments, from materials design specific biomedical applications. This review covers treatments based functional targeting membrane, ranging well-known membrane-anchoring photodynamic therapy recent lysosome-targeting chimaeras protein degradation. diverse mechanisms are introduced in following sections: phototherapy, self-assembly situ biosynthesis degradation proteins by chimeras. In each section, we outline conceptual general derived numerous studies, emphasizing representative examples understand advancements draw inspiration. Finally, some challenges future directions membrane-targeted our perspective. aims engage multidisciplinary readers encourage researchers related fields advance fundamental theories practical applications membrane-targeting agents.

Язык: Английский

Процитировано

27

NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma DOI

Xueyang Fang,

Rui Gong,

Decai Yang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(22), С. 15251 - 15263

Опубликована: Май 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Язык: Английский

Процитировано

25

Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 16, 2024

Developing Type-I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type-II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H

Язык: Английский

Процитировано

23

Nano/genetically engineered cells for immunotherapy DOI Creative Commons

Jingrui Shen,

Yang Zhou, Lichen Yin

и другие.

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

Abstract Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency off‐target toxicity immunotherapeutic drugs. Nano drug systems offer improvements in biodistribution release kinetics but still suffer from shortcomings high immunogenicity, poor penetration across biological barriers, insufficient tissue permeability. Targeted drugs using living cells become an emerging strategy that can take advantage inherent characteristics deal with defects nano systems. Furthermore, themselves be genetically engineered into cellular enhanced immunotherapy. This review provides in‐depth exploration cell‐derived carriers, detailing their properties, functions, commonly used loading strategies. In addition, role modified synergistic effects are also introduced. By summarizing main advancements limitations field, this offers insights potential cell‐based address existing The introduction recent developments evaluation ongoing research will pave way optimization widespread adoption nano/genetically

Язык: Английский

Процитировано

11

Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death DOI

Fangxue Du,

Hongxin Zhao,

Yangmeihui Song

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Язык: Английский

Процитировано

10

Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis DOI
Sijia Wu, Qian Wang, Junhui Du

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Язык: Английский

Процитировано

10

Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(15)

Опубликована: Фев. 16, 2024

Abstract Developing Type‐I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type‐II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H 2 O reactive species (ROS). Herein, we propose electronic acceptor‐triggered photoinduced (a‐PET) strategy promoting separation electron‐hole pairs marriage two organic semiconducting a non‐fullerene scaffold‐based photosensitizer perylene diimide that significantly boost pathway produce plentiful ROS, especially, inducing 3.5‐fold 2.5‐fold amplification hydroxyl (OH⋅) superoxide (O − ⋅) generation. Systematic mechanism reveals intermolecular intramolecular charge after photoirradiation generate competent production radical ion promote process theoretical calculation ultrafast femtosecond transient absorption (fs‐TA) spectroscopy. By complementary diagnosis with photoacoustic imaging second near‐infrared fluorescence imaging, this as‐prepared nanoplatform exhibits fabulous photocytotoxicity in harsh hypoxic conditions terrific cancer revoked abilities living mice. We envision work will broaden insight into high‐efficiency phototheranostics.

Язык: Английский

Процитировано

7

Immunomodulatory metal-based biomaterials for cancer immunotherapy DOI

Kangzhi Yuan,

Cai Zhang,

Xiang-Ying Pan

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 249 - 268

Опубликована: Сен. 12, 2024

Язык: Английский

Процитировано

7