Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 23, 2025
Spinal
cord
injury
(SCI)
is
a
severe
condition
that
frequently
leads
to
permanent
disabilities
and
neurological
dysfunction.
Its
progression
driven
by
multifaceted
pathophysiology,
encompassing
direct
trauma,
secondary
cascades,
intricate
cellular
molecular
responses.
While
current
therapies
focus
on
alleviating
symptoms
restoring
functionality,
achieving
effective
neural
regeneration
in
the
spinal
continues
be
significant
challenge.
Hydrogels,
recognized
for
their
exceptional
biocompatibility,
conductivity,
injectability,
have
shown
great
potential
as
advanced
scaffolds
support
neuronal
axonal
regeneration.
Recently,
these
materials
attracted
interest
field
of
SCI
rehabilitation
research.
This
review
concludes
recent
progress
hydrogel-based
strategies
rehabilitation,
emphasizing
distinct
properties,
underlying
mechanisms,
integration
with
bioactive
molecules,
stem
cells,
complementary
biomaterials.
Hydrogels
foster
providing
tailored
microenvironment,
while
features
such
self-repair,
electrical
controlled
drug
release
significantly
enhance
therapeutic
experimental
models.
explores
hydrogel
technologies
applications,
underscoring
address
challenges
treatment
paving
way
future
clinical
implementation.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(8), С. 4086 - 4153
Опубликована: Янв. 1, 2024
This
review
critically
analyzes
degradable
biomedical
elastomers,
focusing
on
their
degradation,
synthesis,
microstructure,
and
role
in
tissue
repair.
It
guides
experts
balancing
degradation
with
repair
for
improved
applications.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(17), С. 8632 - 8712
Опубликована: Янв. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Апрель 10, 2024
Bioelectricity
plays
a
crucial
role
in
organisms,
being
closely
connected
to
neural
activity
and
physiological
processes.
Disruptions
the
nervous
system
can
lead
chaotic
ionic
currents
at
injured
site,
causing
disturbances
local
cellular
microenvironment,
impairing
biological
pathways,
resulting
loss
of
functions.
Electromagnetic
stimulation
has
ability
generate
internal
currents,
which
be
utilized
counter
tissue
damage
aid
restoration
movement
paralyzed
limbs.
By
incorporating
implanted
materials,
electromagnetic
targeted
more
accurately,
thereby
significantly
improving
effectiveness
safety
such
interventions.
Currently,
there
have
been
significant
advancements
development
numerous
promising
strategies
with
diverse
materials.
This
review
provides
comprehensive
summary
fundamental
theories,
modulating
material
application
strategies,
pre-clinical
therapeutic
effects
associated
for
repair.
It
offers
thorough
analysis
current
techniques
that
employ
materials
enhance
stimulation,
as
well
potential
future
applications.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Май 28, 2024
The
repair
of
irregular
bone
tissue
suffers
severe
clinical
problems
due
to
the
scarcity
an
appropriate
therapeutic
carrier
that
can
match
dynamic
and
complex
damage.
Fortunately,
stimuli-responsive
in
situ
hydrogel
systems
are
triggered
by
a
special
microenvironment
could
be
ideal
method
regenerating
because
injectability,
gelatin,
spatiotemporally
tunable
drug
release.
Herein,
we
introduce
two
main
stimulus-response
approaches,
exogenous
endogenous,
forming
hydrogels
engineering.
First,
summarize
specific
distinct
responses
extensive
range
external
stimuli
(e.g.,
ultraviolet,
near-infrared,
ultrasound,
etc.)
form
created
from
biocompatible
materials
modified
various
functional
groups
or
hybrid
nanoparticles.
Furthermore,
“smart”
hydrogels,
which
respond
endogenous
physiological
environmental
temperature,
pH,
enzyme,
etc.),
achieve
gelation
one
injection
vivo
without
additional
intervention.
Moreover,
mild
chemistry
response-mediated
also
offer
fascinating
prospects
engineering,
such
as
Diels–Alder,
Michael
addition,
thiol-Michael
Schiff
reactions,
etc.
recent
developments
challenges
smart
their
application
administration
engineering
discussed
this
review.
It
is
anticipated
advanced
strategies
innovative
ideas
will
exploited
field
increase
quality
life
for
patients
with
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Small
high‐performance
energy
modules
have
significant
practical
value
in
the
biomedical
field,
such
as
painless
diagnosis,
alleviation
of
gastrointestinal
discomfort,
and
electrical
stimulation
therapy.
However,
due
to
performance
limitations
safety
concerns,
it
is
a
formidable
challenge
design
small,
emerging
ingestible
power
supply.
Here,
fully
supercapacitor
(FISC)
constructed
sargassum
cellulose
nanofiber
presented.
FISCs
exhibit
an
electrode
areal
capacitance
2.29
F
cm
−2
high
density
307
µWh
.
Furthermore,
over
90%
antibacterial
activity
against
Escherichia
coli
achieved
during
self‐discharge
process.
Therefore,
following
insertion
into
enteric
capsule,
this
device
can
enable
disposable
supply
electrostimulation
for
bacteriostasis
intestine
after
being
swallowed
by
human,
which
offers
new
possibilities
scientific
simple
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Окт. 21, 2024
Abstract
Severe
tissue
defects
present
formidable
challenges
to
human
health,
persisting
as
major
contributors
mortality
rates.
The
complex
pathological
microenvironment,
particularly
the
disrupted
immune
landscape
within
these
defects,
poses
substantial
hurdles
existing
regeneration
strategies.
However,
emergence
of
nanobiotechnology
has
opened
a
new
direction
in
immunomodulatory
nanomedicine,
providing
encouraging
prospects
for
and
restoration.
This
review
aims
gather
recent
advances
nanomedicine
foster
regeneration.
We
begin
by
elucidating
distinctive
features
local
microenvironment
defective
tissues
its
crucial
role
Subsequently,
we
explore
design
functional
properties
nanosystems.
Finally,
address
clinical
translation
development,
aiming
propose
potent
approach
enhance
through
synergistic
modulation
integration.
Materials,
Год журнала:
2024,
Номер
17(14), С. 3472 - 3472
Опубликована: Июль 13, 2024
Nerve
injury
can
significantly
impair
motor,
sensory,
and
autonomic
functions.
Understanding
nerve
degeneration,
particularly
Wallerian
the
mechanisms
of
regeneration
is
crucial
for
developing
effective
treatments.
This
manuscript
reviews
use
advanced
hydrogels
that
have
been
researched
to
enhance
regeneration.
Hydrogels,
due
their
biocompatibility,
tunable
properties,
ability
create
a
supportive
microenvironment,
are
being
explored
effectiveness
in
repair.
Various
types
hydrogels,
such
as
chitosan-,
alginate-,
collagen-,
hyaluronic
acid-,
peptide-based
discussed
roles
promoting
axonal
growth,
functional
recovery,
myelination.
Advanced
formulations
incorporating
growth
factors,
bioactive
molecules,
stem
cells
show
significant
promise
overcoming
limitations
traditional
therapies.
Despite
these
advancements,
challenges
achieving
robust
reliable
remain,
necessitating
ongoing
research
optimize
hydrogel-based
interventions
neural
