Materials & Design, Год журнала: 2025, Номер unknown, С. 113842 - 113842
Опубликована: Март 1, 2025
Язык: Английский
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation
Язык: Английский
Процитировано
3
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Abstract Remodeling the adaptive microenvironment with biomaterials presents a promising avenue for addressing chronic inflammation that contributes to spinal cord injury (SCI) repair. Hydrogels have been widely employed enhance tissue regeneration following SCI. Additionally, zinc (Zn) ions are effective in immune modulation central nervous system. However, significant challenges remain preparing hydrogels combining bioactive Zn 2+ biological functionality traumatic SCI In this study, self‐healing hydrogel composed of an alginate network based on dynamic /bisphosphonate (BP) cross–linking, and silk fibroin interpenetrating polymer is reported. It observed neurite outgrowth promoted by shows dependency concentration. Moreover, ‐releasing enhances neuronal axon growth influences neural stem cell proliferation differentiation. addition, regulates microglial fate upregulating anti‐inflammatory signaling molecule A20 through inhibition NF‐κB pathway. Therefore, effectively improves response while promoting functional recovery, including motor, sensory, bladder function completely transected These results indicate /BP‐based holds potential treatment.
Язык: Английский
Процитировано
2
Bioactive Materials, Год журнала: 2025, Номер 46, С. 531 - 554
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101536 - 101536
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Conductive hydrogels provide a flexible platform technology that enables the development of personalized materials for various neuronal diagnostic and therapeutic applications, combining complementary properties conductive hydrogels. By ensuring conductivity through materials, largely compensate rigidity traditional inorganic making them suitable substitute. To adapt to different working environments, exhibit excellent properties, such as mechanical adhesion, biocompatibility, which further expand their applications. This review summarizes fabrication methods, applications in neural interfaces. Finally, prevailing challenges outlines future directions field interfaces are provided, emphasizing need interdisciplinary research address issues long‐term stability scalability production.
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2025, Номер 50, С. 134 - 151
Опубликована: Апрель 6, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134591 - 134591
Опубликована: Авг. 8, 2024
Язык: Английский
Процитировано
7
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane conductive polypyrrole construct stress-electric coupling hydrogel microspheres. molecular slippage mechanism structure stores releases mechanical energy, reducing loss, barium titanate enables stress-electricity conversion, conjugated π-electron movement network improves internal electron transfer efficiency microspheres, thereby for first time. Compared traditional low-dissipation microspheres increased by 2.3 times, energy decreased 43%. At cellular level, electrical signals generated triggered Ca
Язык: Английский
Процитировано
1