Ultrasound-driven piezoelectric hydrogel enhances Schwann/neural stem cell Co-transplantation for spinal cord injury repair DOI Creative Commons

Haifeng Wang,

Wencan Zhang, Yiming Ren

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113842 - 113842

Опубликована: Март 1, 2025

Язык: Английский

Conducting Hydrogel‐Based Neural Biointerfacing Technologies DOI Open Access
Pei Zhang, Yifan Yang,

Zhaobo Li

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Язык: Английский

Процитировано

3

Smart responsive in situ hydrogel systems applied in bone tissue engineering DOI Creative Commons

Shunli Wu,

Tingting Gai,

Jie Chen

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Май 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Язык: Английский

Процитировано

11

Zinc‐Directed Coordination Network Hydrogels for A20‐Mediated Inflammation Modulation and Enhanced Axonal Regeneration in Spinal Cord Injury DOI Open Access
Jianye Zhang, Yisheng Gao, Miao Zhang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Abstract Remodeling the adaptive microenvironment with biomaterials presents a promising avenue for addressing chronic inflammation that contributes to spinal cord injury (SCI) repair. Hydrogels have been widely employed enhance tissue regeneration following SCI. Additionally, zinc (Zn) ions are effective in immune modulation central nervous system. However, significant challenges remain preparing hydrogels combining bioactive Zn 2+ biological functionality traumatic SCI In this study, self‐healing hydrogel composed of an alginate network based on dynamic /bisphosphonate (BP) cross–linking, and silk fibroin interpenetrating polymer is reported. It observed neurite outgrowth promoted by shows dependency concentration. Moreover, ‐releasing enhances neuronal axon growth influences neural stem cell proliferation differentiation. addition, regulates microglial fate upregulating anti‐inflammatory signaling molecule A20 through inhibition NF‐κB pathway. Therefore, effectively improves response while promoting functional recovery, including motor, sensory, bladder function completely transected These results indicate /BP‐based holds potential treatment.

Язык: Английский

Процитировано

2

3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair DOI Creative Commons
Jia Yang,

Kunkoo Kim,

Yaosai Liu

и другие.

Bioactive Materials, Год журнала: 2025, Номер 46, С. 531 - 554

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1

Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair DOI
Kai Zhang,

Runlin Wen,

Wanrong Ma

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.

Язык: Английский

Процитировано

1

Designing hydrogel for application in spinal surgery DOI Creative Commons

Rongpeng Dong,

Shuang Zheng, Xueliang Cheng

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101536 - 101536

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

1

Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications DOI Creative Commons
Xinyu Xue, Lu Han, Han Cai

и другие.

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Conductive hydrogels provide a flexible platform technology that enables the development of personalized materials for various neuronal diagnostic and therapeutic applications, combining complementary properties conductive hydrogels. By ensuring conductivity through materials, largely compensate rigidity traditional inorganic making them suitable substitute. To adapt to different working environments, exhibit excellent properties, such as mechanical adhesion, biocompatibility, which further expand their applications. This review summarizes fabrication methods, applications in neural interfaces. Finally, prevailing challenges outlines future directions field interfaces are provided, emphasizing need interdisciplinary research address issues long‐term stability scalability production.

Язык: Английский

Процитировано

1

Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis DOI
Moran Huang, Wan Li, Yaying Sun

и другие.

Bioactive Materials, Год журнала: 2025, Номер 50, С. 134 - 151

Опубликована: Апрель 6, 2025

Язык: Английский

Процитировано

1

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects DOI
Na Li,

Jintao He

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134591 - 134591

Опубликована: Авг. 8, 2024

Язык: Английский

Процитировано

7

Slide‐Ring Structured Stress‐Electric Coupling Hydrogel Microspheres for Low‐Loss Transduction Between Tissues DOI Open Access
Fan Wang, Xiaoyu Han, Zeyu Han

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane conductive polypyrrole construct stress-electric coupling hydrogel microspheres. molecular slippage mechanism structure stores releases mechanical energy, reducing loss, barium titanate enables stress-electricity conversion, conjugated π-electron movement network improves internal electron transfer efficiency microspheres, thereby for first time. Compared traditional low-dissipation microspheres increased by 2.3 times, energy decreased 43%. At cellular level, electrical signals generated triggered Ca

Язык: Английский

Процитировано

1