Electrically Conductive Injectable Silk/PEDOT: PSS Hydrogel for Enhanced Neural Network Formation DOI Creative Commons
Rajiv Borah, Julia O’Sullivan, Meenakshi Suku

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 24, 2024

With no effective treatments for functional recovery after injury, spinal cord injury (SCI) remains one of the unresolved healthcare challenges. Human induced pluripotent stem cell (hiPSC) transplantation is a versatile patient-specific regenerative approach SCI. Injectable electroconductive hydrogel (ECH) can further enhance efficacy through minimally invasive manner as well recapitulate native bioelectrical microenvironment neural tissue. Given these considerations, we report novel ECH prepared self-assembly facilitated in situ gelation natural silk fibroin (SF) derived from mulberry Bombyx mori and electrically conductive PEDOT:PSS. PEDOT:PSS was pre-stabilized to prevent potential delamination its hydrophilic PSS chain under aqueous environment using 3% (v/v) (3-glycidyloxypropyl)trimethoxysilane (GoPS) (w/v) poly(ethylene glycol)diglycidyl ether (PeGDE). The resultant formulations are easily injectable with standard hand force flow point below 100 Pa good shear-thinning properties. unmodified GoPS-modified PEDOT:PSS, that is, SF/PEDOT SF/PEDOTGoP maintain comparable elastic modulus (~10-60 kPa) physiological condition, indicating their flexibility. ECHs also display improved structural recoverability (~70%-90%) compared versions (~30%-80%), indicated by three interval time thixotropy (3ITT) test. Additionally, possess electrical conductivity range ~0.2-1.2 S/m (1-10 S/m), ability mimic environment. Approximately 80% or more survival observed when hiPSC-derived cortical neurons astrocytes were encapsulated within ECHs. These support maturation embedded 7 days, fostering development complex, interconnected network long axonal processes promoting synaptogenesis. results underline therapy regeneration.

Language: Английский

Conducting Hydrogel‐Based Neural Biointerfacing Technologies DOI Open Access
Pei Zhang, Yifan Yang,

Zhaobo Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Language: Английский

Citations

2
Smart responsive in situ hydrogel systems applied in bone tissue engineering DOI Creative Commons

Shunli Wu,

Tingting Gai,

Jie Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Language: Английский

Citations

11
Slide‐Ring Structured Stress‐Electric Coupling Hydrogel Microspheres for Low‐Loss Transduction Between Tissues DOI Open Access
Fan Wang, Xiaoyu Han, Zeyu Han

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane conductive polypyrrole construct stress-electric coupling hydrogel microspheres. molecular slippage mechanism structure stores releases mechanical energy, reducing loss, barium titanate enables stress-electricity conversion, conjugated π-electron movement network improves internal electron transfer efficiency microspheres, thereby for first time. Compared traditional low-dissipation microspheres increased by 2.3 times, energy decreased 43%. At cellular level, electrical signals generated triggered Ca

Language: Английский

Citations

1
3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair DOI Creative Commons
Jia Yang,

Kunkoo Kim,

Yaosai Liu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 531 - 554

Published: Jan. 8, 2025

Language: Английский

Citations

1
Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair DOI
Kai Zhang,

Runlin Wen,

Wanrong Ma

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.

Language: Английский

Citations

1
Designing hydrogel for application in spinal surgery DOI Creative Commons

Rongpeng Dong,

Shuang Zheng, Xueliang Cheng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101536 - 101536

Published: Feb. 3, 2025

Language: Английский

Citations

1
Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications DOI Creative Commons
Xinyu Xue, Lu Han, Han Cai

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Conductive hydrogels provide a flexible platform technology that enables the development of personalized materials for various neuronal diagnostic and therapeutic applications, combining complementary properties conductive hydrogels. By ensuring conductivity through materials, largely compensate rigidity traditional inorganic making them suitable substitute. To adapt to different working environments, exhibit excellent properties, such as mechanical adhesion, biocompatibility, which further expand their applications. This review summarizes fabrication methods, applications in neural interfaces. Finally, prevailing challenges outlines future directions field interfaces are provided, emphasizing need interdisciplinary research address issues long‐term stability scalability production.

Language: Английский

Citations

1
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis DOI
Moran Huang, Wan Li, Yaying Sun

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 134 - 151

Published: April 6, 2025

Language: Английский

Citations

1
Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects DOI
Na Li,

Jintao He

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134591 - 134591

Published: Aug. 8, 2024

Language: Английский

Citations

7
Tissue‐Adaptive BSA Hydrogel with Dual Release of PTX and bFGF Promotes Spinal Cord Injury Repair via Glial Scar Inhibition and Axon Regeneration DOI Open Access
Sipin Zhu, Qiuji Wu,

Yibo Ying

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Spinal cord injury (SCI) is a severe clinical disease usually accompanied by activated glial scar, neuronal axon rupture, and disabled motor function. To mimic the microenvironment of SCI site, hydrogel system with comparable mechanical property to spinal desirable. Therefore, novel elastic bovine serum albumin (BSA) fabricated excellent adhesive, injectable, biocompatible properties. The used deliver paclitaxel (PTX) together basic fibroblast growth factor (bFGF) inhibit scar formation as well promote regeneration function for repair. Due specific interaction BSA both drugs, bFGF, PTX can be controllably released from achieve an effective concentration at wound site during process. Moreover, benefiting combination this bFGF/PTX@BSA significantly aided repair promoting elongation axons across reduced reactive astrocyte secretion. In addition, remarkable anti-apoptosis nerve cells evident system. Subsequently, multi-functionalized drug improved rats after SCI. These results reveal that ideal functionalized material in

Language: Английский

Citations

4