Smart responsive in situ hydrogel systems applied in bone tissue engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Language: Английский

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Conducting Hydrogel‐Based Neural Biointerfacing Technologies

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Language: Английский

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Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Conductive hydrogels provide a flexible platform technology that enables the development of personalized materials for various neuronal diagnostic and therapeutic applications, combining complementary properties conductive hydrogels. By ensuring conductivity through materials, largely compensate rigidity traditional inorganic making them suitable substitute. To adapt to different working environments, exhibit excellent properties, such as mechanical adhesion, biocompatibility, which further expand their applications. This review summarizes fabrication methods, applications in neural interfaces. Finally, prevailing challenges outlines future directions field interfaces are provided, emphasizing need interdisciplinary research address issues long‐term stability scalability production.

Language: Английский

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Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134591 - 134591

Published: Aug. 8, 2024

Language: Английский

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Slide‐Ring Structured Stress‐Electric Coupling Hydrogel Microspheres for Low‐Loss Transduction Between Tissues

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane conductive polypyrrole construct stress-electric coupling hydrogel microspheres. molecular slippage mechanism structure stores releases mechanical energy, reducing loss, barium titanate enables stress-electricity conversion, conjugated π-electron movement network improves internal electron transfer efficiency microspheres, thereby for first time. Compared traditional low-dissipation microspheres increased by 2.3 times, energy decreased 43%. At cellular level, electrical signals generated triggered Ca

Language: Английский

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Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123083 - 123083

Published: Jan. 5, 2025

Language: Английский

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3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 531 - 554

Published: Jan. 8, 2025

Language: Английский

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Electrostimulation combined with biodegradable electroactive oriented nanofiber polycaprolactone/gelatin/carbon nanotube to accelerate wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101490 - 101490

Published: Jan. 14, 2025

Wound healing is a complex but precise physiological process. Howener, existing treatments are often difficult to meet the needs of different wound healing. With background that exogenous electrical stimulation (ES) has been proven be effective in regulating cell behavior, we constructed electroactive dressing derived from carbon nanotubes (CNT) by electrospinning technology. The scaffold moderate hydrophilicity, which benefits collecting effusion, adhering site, and safely removing. Furthermore, oriented structure potential promote growth, while coupling endogenous electric field (EFs) ES could effectively regulate phenotype macrophages reshape immune microenvironment. At same time, active promotes secretion factors proliferation migration fibroblasts endothelial cells. In vivo assays further confirm PCL/GE/CNT combined strategy can significantly inhibit early inflammatory response, promoting vascular regeneration collagen deposition. RNA sequencing analysis used reveal mechanism at molecular level. Overall, this study employed composite combining CNT with moderately hydrophilic biocompatible nanofibers achieve delivery simply effectively, improving tissue engineering outcomes. This innovative provides feasible approach for efficient repair, an important experimental basis theoretical guidance future development skin engineering.

Language: Английский

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Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.

Language: Английский

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Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuries

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The clinical treatment of central nervous system (CNS) injuries presents significant challenges due to the inflammatory microenvironment (IME) induced by CNS injury, which inhibits spontaneous neuronal regeneration. Biomimetic biomaterial‐based IMEs for repair, facilitate reconstruction neural regeneration circuits, show promise. In this study, development novel bioactive peptide nanofibers (PNFs)/chitosan (CS)/VD11 (VDELWPPWLPC) hydrogels (named as PCV) is reported, created reinforcing composite PNFs/CS with a frog‐derived neuroregenerative (VD11). exhibit 3D porous structure, high thermosensitivity, good injectability, and enhanced neurotrophic properties, making them promising candidates repair. in vitro tests indicate that PCV can promote proliferation, migration, differentiation stem cells into neurons, well guide axonal growth. Additionally, they help mitigate responses reducing macrophage activation astrocyte while promoting neovascularization. vivo animal experimentsdemonstrate enhance blood supply damaged area migration colonization endogenous support Furthermore, reduce immune limit excessive significantly improving motor function recovery rats spinal cord injuries. these findings, it suggested provide strategy treating regulating IME.

Language: Английский

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