Calcium Hexacyanoferrate Nanozyme Enhances Plant Stress Resistance by Oxidative Stress Alleviation and Heavy Metal Removal
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 10, 2024
Abstract
Oxidative
damage,
exacerbated
by
the
excessive
accumulation
of
reactive
oxygen
species
(ROS),
profoundly
inhibits
both
crop
growth
and
yield.
Herein,
a
biocompatible
nanozyme,
calcium
hexacyanoferrate
nanoparticles
(CaHCF
NPs),
targeting
ROS
is
developed,
to
mitigate
oxidative
damage
sequestrate
heavy
metal
ions
during
plant
growth.
Uniquely,
CaHCF
NPs
feature
multifaced
enzyme‐like
activities,
involving
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
peroxidase,
thiol
ascorbate
which
enable
them
neutralize
ROS.
Furthermore,
promote
calcium‐cadmium
exchange
process,
diminishing
uptake
metals.
Importantly,
120
µg
mL
−1
alleviate
inhibitory
effects
hydrogen
peroxide
cadmium
chloride
on
Arabidopsis
tomato.
The
activities
SOD,
POD,
CAT
increase
46.2%,
74.4%,
48.3%,
respectively,
meanwhile
level
rises
72.4%
in
under
stress.
Moreover,
boost
expression
genes
associated
with
antioxidation,
detoxification,
nutrient
transport,
stress
resistance.
These
findings
unveil
significant
potential
nanoplatforms
equipped
nanozymes
alleviating
plants,
not
only
regulate
but
also
substantially
ameliorate
yield
quality,
heralding
new
era
agricultural
nanotechnology.
Язык: Английский
Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy
Materials Today Chemistry,
Год журнала:
2024,
Номер
43, С. 102455 - 102455
Опубликована: Дек. 10, 2024
Язык: Английский
Fe2O3 Hollow Multishelled Structure Endowed Temporal Sequential Mass Release for Apoptosis/Ferroptosis‐Induced Combined Cancer Therapy
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
Abstract
Cisplatin
(CDDP)
combined
with
pemetrexed
(MTA)
is
commonly
employed
in
the
treatment
of
advanced
non‐small
cell
lung
cancer.
However,
conventional
clinical
administration
methods
fail
to
achieve
precise
spatiotemporal
delivery
within
tumor
microenvironment
(TME),
resulting
inadequate
control
local
drug
concentrations
and
impeding
synergistic
efficacy
chemotherapeutic
drugs.
Aiming
address
this
issue,
Fe
2
O
3
hollow
multi‐shelled
structure
(HoMS)
nanocarriers
spatiotemporally
controlled
release
properties
co‐encapsulated
CDDP
MTA
into
nanocarrier
are
developed.
The
confined
provided
by
‐HoMS
enables
a
targeted
temporal
sequential
tailored
requirements.
Furthermore,
chemotherapy‐induced
DNA
damage
leads
apoptosis,
accompanied
substantial
generation
reactive
oxygen
species
(ROS).
disruption
ROS
homeostasis
subsequently
activates
ferroptosis
pathway
mediated
‐HoMS.
In
summary,
exhibits
highly
two
drugs
TME,
HoMS
further
involved
regulation
ferroptosis,
realizing
triple
system
comprising
CDDP‐MTA‐Fe
2+
thus
significantly
enhancing
anti‐tumor
against
This
study
proposes
novel
approach
for
optimizing
design,
addressing
challenge
precisely
tumors.
Язык: Английский
Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
MXenzymes,
a
promising
class
of
catalytic
therapeutic
material,
offer
great
potential
for
tumor
treatment,
but
they
encounter
significant
obstacles
due
to
suboptimal
efficiency
and
kinetics
in
the
microenvironment
(TME).
Herein,
this
study
draws
inspiration
from
electronic
structure
transition
metal
vanadium,
proposing
leverage
TME
specific-features
induce
structural
transformations
sheet-like
vanadium
carbide
MXenzymes
(TVMz).
These
trigger
cascading
reactions
that
amplify
oxidative
stress,
thereby
significantly
enhancing
multimodal
therapy.
Specifically,
engineered
HTVMz,
coated
with
hyaluronic
acid,
exhibits
good
stability
generates
thermal
effect
under
NIR-II
laser
irradiation.
The
effect,
combined
characteristics,
facilities
transformation
into
ultra-small
oxide
nanozymes
(VOx).
enlarged
surface
area
VOx
substantially
enhances
ROS
regeneration
amplifies
which
promotes
lysosomal
permeability
induces
endoplasmic
reticulum
stress.
high-valent
interacts
intracellular
glutathione,
disrupting
redox
homeostasis
intensifying
stress
further.
amplifications
accelerate
apoptosis,
ferroptosis,
suppress
HSP90
expression.
Consequently,
heightened
sensitivity
HTVMz
synergistically
cell
death
via
pathways.
This
presents
an
innovative
strategy
therapy
by
manipulating
structures,
advancing
field
Язык: Английский
A review of enhancement strategies for pyrocatalysis of perovskite oxides and their applications
Journal of Materials Chemistry A,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
this
review,
strategies
to
enhance
the
pyrocatalytic
performance
of
perovskite
oxides
are
highlighted.
The
applications
oxide
pyrocatalysis
then
summarized.
Finally,
outlook
for
presented.
Язык: Английский
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
690, С. 137332 - 137332
Опубликована: Март 14, 2025
Язык: Английский
Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release
Materials Chemistry and Physics,
Год журнала:
2025,
Номер
unknown, С. 130699 - 130699
Опубликована: Март 1, 2025
Язык: Английский
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Poor
prognosis
and
chemotherapy
response
stem
from
difficulties
in
precise
targeting
the
lack
of
effective
synergistic
treatments.
Nanozymes
show
promising
potential
tumor
chemodynamic
therapy
(CDT)
by
catalyzing
hydrogen
peroxide
(H₂O₂)
decomposition
glutathione
depletion
microenvironment
(TME).
However,
integrating
with
CDT
remains
challenging.
In
this
study,
a
porous
Fe/Cu
bimetallic
nanozyme
carrier
(FeCuNPs)
is
developed
for
co‐loading
humanized
3F8
anti‐GD2
disialoganglioside
antibody
(3F8)
novel
pyridazinone‐based
chemotherapeutic
agent
(IMB),
forming
nanoreactor
(3F8@FeCuNPs@IMB)
targeted
CDT.
The
responds
specifically
to
acidic
TME
as
primary
insurance,
allowing
controlled
release
IMB
at
site.
coating
on
surface
acts
secondary
minimizing
drug
leakage
during
delivery
process
ensuring
chemotherapy.
Furthermore,
FeCuNPs
act
peroxidase‐like
(POD)
oxidase‐like
(GSHOX)
enzymes,
hydroxyl
radical
(•OH)
generation
depleting
excess
GSH,
enhancing
results
vitro
vivo
indicate
that
dual
insurance
designed
3F8@FeCuNPs@IMB
offers
prospect
targeted,
precise,
combination
against
melanoma.
Язык: Английский
Integrating Ferroelectric Fields with Active Sites for the Construction of Highly Efficient Nanozymes
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Enhancing
nanozymes'
catalytic
activity
is
challenging
yet
crucial
for
practical
applications.
Herein,
inspired
by
the
electrostatic
preorganization
effect
in
process
of
natural
protein
enzymes,
a
nanozyme
constructed
decorating
ferroelectric
BaTiO3
nanoparticles
(BTO)
with
hemin,
which
often
regarded
as
active
site
horseradish
peroxidase
(HRP).
The
Hemin-BTO
demonstrates
excellent
peroxidase-like
(POD-like)
constant
(Kcat)
up
to
9.71
×
105
s-1
and
1.41
106
TMB
H2O2
substrates,
ca.
240-fold
400-fold
greater
than
that
HRP.
Theoretical
studies
utilizing
Density
Functional
Theory
calculations
revealed
underlying
mechanism.
spontaneous
polarization
electric
field
BTO
adjusts
internal
thereby
enhancing
affinity
between
substrate.
Simultaneously,
existence
hemin
reduced
recombination
charge
carriers,
accelerated
electron
transfer,
thus
promoted
generation
reactive
oxygen
species,
effectively
its
POD-like
activity.
In
addition,
has
been
successfully
used
establish
an
immunoassay
human
brain
natriuretic
peptide.
This
work
presented
feasible
strategy
construct
nanozymes
highly
integrating
fields
enzymes.
Язык: Английский