Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 43, P. 102455 - 102455

Published: Dec. 10, 2024

Language: Английский

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Calcium Hexacyanoferrate Nanozyme Enhances Plant Stress Resistance by Oxidative Stress Alleviation and Heavy Metal Removal

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Abstract Oxidative damage, exacerbated by the excessive accumulation of reactive oxygen species (ROS), profoundly inhibits both crop growth and yield. Herein, a biocompatible nanozyme, calcium hexacyanoferrate nanoparticles (CaHCF NPs), targeting ROS is developed, to mitigate oxidative damage sequestrate heavy metal ions during plant growth. Uniquely, CaHCF NPs feature multifaced enzyme‐like activities, involving superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase, thiol ascorbate which enable them neutralize ROS. Furthermore, promote calcium‐cadmium exchange process, diminishing uptake metals. Importantly, 120 µg mL −1 alleviate inhibitory effects hydrogen peroxide cadmium chloride on Arabidopsis tomato. The activities SOD, POD, CAT increase 46.2%, 74.4%, 48.3%, respectively, meanwhile level rises 72.4% in under stress. Moreover, boost expression genes associated with antioxidation, detoxification, nutrient transport, stress resistance. These findings unveil significant potential nanoplatforms equipped nanozymes alleviating plants, not only regulate but also substantially ameliorate yield quality, heralding new era agricultural nanotechnology.

Language: Английский

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Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Language: Английский

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Fe₂O₃ Hollow Multishelled Structure Endowed Temporal Sequential Mass Release for Apoptosis/Ferroptosis‐Induced Combined Cancer Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Cisplatin (CDDP) combined with pemetrexed (MTA) is commonly employed in the treatment of advanced non‐small cell lung cancer. However, conventional clinical administration methods fail to achieve precise spatiotemporal delivery within tumor microenvironment (TME), resulting inadequate control local drug concentrations and impeding synergistic efficacy chemotherapeutic drugs. Aiming address this issue, Fe 2 O 3 hollow multi‐shelled structure (HoMS) nanocarriers spatiotemporally controlled release properties co‐encapsulated CDDP MTA into nanocarrier are developed. The confined provided by ‐HoMS enables a targeted temporal sequential tailored requirements. Furthermore, chemotherapy‐induced DNA damage leads apoptosis, accompanied substantial generation reactive oxygen species (ROS). disruption ROS homeostasis subsequently activates ferroptosis pathway mediated ‐HoMS. In summary, exhibits highly two drugs TME, HoMS further involved regulation ferroptosis, realizing triple system comprising CDDP‐MTA‐Fe 2+ thus significantly enhancing anti‐tumor against This study proposes novel approach for optimizing design, addressing challenge precisely tumors.

Language: Английский

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A review of enhancement strategies for pyrocatalysis of perovskite oxides and their applications

Journal of Materials Chemistry A, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this review, strategies to enhance the pyrocatalytic performance of perovskite oxides are highlighted. The applications oxide pyrocatalysis then summarized. Finally, outlook for presented.

Language: Английский

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Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

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Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130699 - 130699

Published: March 1, 2025

Language: Английский

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Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Language: Английский

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Integrating Ferroelectric Fields with Active Sites for the Construction of Highly Efficient Nanozymes

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Enhancing nanozymes' catalytic activity is challenging yet crucial for practical applications. Herein, inspired by the electrostatic preorganization effect in process of natural protein enzymes, a nanozyme constructed decorating ferroelectric BaTiO3 nanoparticles (BTO) with hemin, which often regarded as active site horseradish peroxidase (HRP). The Hemin-BTO demonstrates excellent peroxidase-like (POD-like) constant (Kcat) up to 9.71 × 105 s-1 and 1.41 106 TMB H2O2 substrates, ca. 240-fold 400-fold greater than that HRP. Theoretical studies utilizing Density Functional Theory calculations revealed underlying mechanism. spontaneous polarization electric field BTO adjusts internal thereby enhancing affinity between substrate. Simultaneously, existence hemin reduced recombination charge carriers, accelerated electron transfer, thus promoted generation reactive oxygen species, effectively its POD-like activity. In addition, has been successfully used establish an immunoassay human brain natriuretic peptide. This work presented feasible strategy construct nanozymes highly integrating fields enzymes.

Language: Английский

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Hydrogen Incorporation Selectively Modulates the Catalytic Performance of Pd Nanozymes for Cascade-Catalytic Tumor Therapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Pd-based nanozymes have emerged as promising alternatives to natural enzymes, but their application is still constrained due suboptimal activity and poor specificity. As efficient hydrogen storage nanomaterials, the specific implications of implanted on enzyme-mimicking nanomaterials remain largely uninvestigated. In this study, we discovered that hydrogenation process significantly enhances enzyme-like although reaction specificity varies in dependence synthetic route Pd hydrides. Pd/H2 nanocubes (NCs), which are synthesized by directly injecting gas into a solution containing NCs, exhibit selective enhancement antioxidative against cytotoxic peroxide (H2O2), superoxide anion (O2•-), hydroxyl radical (•OH) sustained release bioreductive hydrogen. contrast, stable hydride prepared through situ catalytic decomposition alternative sources atoms, remarkable exclusive H2O2 activation pathways, specifically exhibiting peroxidase (POD)-like catalase (CAT)-like activities. Multiple spectroscopic characterizations density functional theory (DFT) calculations confirmed high PdH NCs arise from lattice tensile strain electronic structure change. Based these findings, PdH/glucose oxidase (GOx) nanocomplex was developed for cascade catalysis tumor therapy. This work not only reveals formation can influence both selectivity also provides viable strategy precise regulation hydrogen-loading nanozymes.

Language: Английский

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