Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Язык: Английский
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Gouty arthritis is one of the most common forms inflammatory and has brought a significant burden on patients society. Current strategies for managing gout primarily focus long-term urate-lowering therapy. With rapid advancement point-of-care testing (POCT) technology, continuous monitoring gout-related biomarkers like uric acid (UA) or cytokines can provide personalized diagnosis management. In this study, plug-in design microneedle electrode array (PIMNA) was developed integrated into multi-parameter sensing portable system in combination with embedded circuits mobile application. The enabled real-time, situ, dynamic biomarkers, including UA, reactive oxygen species (ROS), pH at gouty joints. demonstrated wide linear response range, excellent selectivity, stability, reproducibility, reliable signal transmission performance. vivo experiments real-time capability PIMNA ROS, pH, showing potential to facilitate management inflammation assessment. Prospectively, enables quantitative analysis complexity diversity gout, presenting promising applications clinical practice. This work provides unique strategy broader arthritic disease treatment.
Язык: Английский
Процитировано
2
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.
Язык: Английский
Процитировано
2
Biosensors and Bioelectronics, Год журнала: 2025, Номер 273, С. 117159 - 117159
Опубликована: Янв. 11, 2025
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Abstract Current early cancer diagnostic technologies, such as imaging, molecular tests, endoscopic techniques, and biopsies, face considerable challenges in low‐and middle‐income countries (LMICs) due to high costs, procedural complexity, limited resource access. Microneedle‐based liquid biopsy for skin interstitial fluid (ISF) offers a practical minimally invasive alternative diagnosis these settings. This review systematically examines ISF methods their effectiveness capturing biomarkers directly from the assesses potential address needs low‐resource environments. Recent innovations microneedle design underscore enabling early, accessible detection tailored LMICs' needs. Additionally, integrating artificial intelligence (AI) data interpretation is proposed way enhance accuracy enable real‐time point‐of‐care (POC) applications. Collectively, advances illustrate flexible, scalable model diagnostics, with significant implications improving healthcare quality resource‐limited
Язык: Английский
Процитировано
1
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Precise control over drug release rates is critical for enhancing therapeutic efficacy, reducing side effects, and maintaining stable levels. While microneedles (MNs) offer a promising approach transdermal delivery, conventional passive‐response systems often lack adaptability across diverse drugs disease models, limiting their versatility. Here, this work presents flexible bioelectronic microneedle patch (FBMP) that integrates electronics actively controlled delivery. The FBMP incorporates printed circuit board (FPCB), eutectic gallium‐indium (EGaIn) heating film, dual‐layer with polyvinyl alcohol (PVA) core polycaprolactone (PCL) shell. This configuration allows real‐time adjustment of the thermal response rate via smartphone‐controlled Bluetooth, achieving rapid within 2 min or sustained 10 h. In various animal demonstrate versatility in delivering multiple types, optimizing minimizing effects both acute chronic conditions. Overall, introduces flexible, universal electronic platform significant potential to advance precision personalized medicine by enabling customizable, release.
Язык: Английский
Процитировано
1
Chemosensors, Год журнала: 2025, Номер 13(2), С. 68 - 68
Опубликована: Фев. 15, 2025
Microneedles (MNs) are miniature medical devices, presented as an array of micro-scale needles, each under 1 mm in height with sharp tips. MN technology is becoming a diagnostic platform associated several qualities: no pain and risk infection, offering accuracy, comfort, usability. Monitoring biomarkers interstitial fluid (ISF) real time crucial for tracking changes metabolism assisting the early diagnosis chronic illnesses. Some examples sensors summarized here: real-time sensing two metabolites (lactate glucose or alcohol glucose), transdermal tracing pH, Na+, K+, Ca2+, Li+, Cl−, methotrexate (MTX) monitoring, tyrosinase enzyme melanoma biomarker, integration CRISPR nucleic acid analysis, monitoring plant sap pH leaves plants. The challenges to be addressed realize transition widespread One Health solutions analyzed.
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Abstract Driven by the growing burden of chronic diseases and limited public healthcare resources, portable health monitoring platforms are widely developed to enable continuous timely dissemination provide users with management disease prevention. However, it is still a challenge for precision fully bio‐integrated electronic devices achieve stable physiological signal recording over long periods time. Recently, semi‐implantable bioelectronics (SI‐bioelectronics) have excelled in real‐time, long‐term, high‐sensitivity pathological signals minimal invasiveness, enabled precise microneedle sensing probes. In this review, comprehensive overview recent advancements SI‐bioelectronics provided, focus on their structures, design considerations, performances biochemical indicators, bioelectrical signals, biomechanical signals. Opportunities research such as smart medicine Internet Things also discussed, which will drive toward intelligence efficiency.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156130 - 156130
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
4
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(32), С. 7787 - 7813
Опубликована: Янв. 1, 2024
Various non-invasive delivery systems have recently been developed as an alternative to conventional injections. Local transdermal administration represents the most attractive method due low systemic side effects, excellent ease of administration, and persistent drug release. The tympanic membrane (TM), a major barrier between outer middle ear, has similar structure stratum corneum compared surface skin. After several attempts, trans-tympanic regarded promising option in treatment inner ear diseases. round window (RWM) was possible approach from ear. improved permeability nanocarriers crossing RWM is current hotspot therapeutics for In this review, we include latest studies exploring treat Both passive active are described. A summary benefits disadvantages various clinical practice production procedures introduced. Finally, future approaches its effective application system characterised.
Язык: Английский
Процитировано
3
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Язык: Английский
Процитировано
0