Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Gouty arthritis is one of the most common forms inflammatory and has brought a significant burden on patients society. Current strategies for managing gout primarily focus long-term urate-lowering therapy. With rapid advancement point-of-care testing (POCT) technology, continuous monitoring gout-related biomarkers like uric acid (UA) or cytokines can provide personalized diagnosis management. In this study, plug-in design microneedle electrode array (PIMNA) was developed integrated into multi-parameter sensing portable system in combination with embedded circuits mobile application. The enabled real-time, situ, dynamic biomarkers, including UA, reactive oxygen species (ROS), pH at gouty joints. demonstrated wide linear response range, excellent selectivity, stability, reproducibility, reliable signal transmission performance. vivo experiments real-time capability PIMNA ROS, pH, showing potential to facilitate management inflammation assessment. Prospectively, enables quantitative analysis complexity diversity gout, presenting promising applications clinical practice. This work provides unique strategy broader arthritic disease treatment.
Language: Английский
Citations
1
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Precise control over drug release rates is critical for enhancing therapeutic efficacy, reducing side effects, and maintaining stable levels. While microneedles (MNs) offer a promising approach transdermal delivery, conventional passive‐response systems often lack adaptability across diverse drugs disease models, limiting their versatility. Here, this work presents flexible bioelectronic microneedle patch (FBMP) that integrates electronics actively controlled delivery. The FBMP incorporates printed circuit board (FPCB), eutectic gallium‐indium (EGaIn) heating film, dual‐layer with polyvinyl alcohol (PVA) core polycaprolactone (PCL) shell. This configuration allows real‐time adjustment of the thermal response rate via smartphone‐controlled Bluetooth, achieving rapid within 2 min or sustained 10 h. In various animal demonstrate versatility in delivering multiple types, optimizing minimizing effects both acute chronic conditions. Overall, introduces flexible, universal electronic platform significant potential to advance precision personalized medicine by enabling customizable, release.
Language: Английский
Citations
1
Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 68 - 68
Published: Feb. 15, 2025
Microneedles (MNs) are miniature medical devices, presented as an array of micro-scale needles, each under 1 mm in height with sharp tips. MN technology is becoming a diagnostic platform associated several qualities: no pain and risk infection, offering accuracy, comfort, usability. Monitoring biomarkers interstitial fluid (ISF) real time crucial for tracking changes metabolism assisting the early diagnosis chronic illnesses. Some examples sensors summarized here: real-time sensing two metabolites (lactate glucose or alcohol glucose), transdermal tracing pH, Na+, K+, Ca2+, Li+, Cl−, methotrexate (MTX) monitoring, tyrosinase enzyme melanoma biomarker, integration CRISPR nucleic acid analysis, monitoring plant sap pH leaves plants. The challenges to be addressed realize transition widespread One Health solutions analyzed.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract Driven by the growing burden of chronic diseases and limited public healthcare resources, portable health monitoring platforms are widely developed to enable continuous timely dissemination provide users with management disease prevention. However, it is still a challenge for precision fully bio‐integrated electronic devices achieve stable physiological signal recording over long periods time. Recently, semi‐implantable bioelectronics (SI‐bioelectronics) have excelled in real‐time, long‐term, high‐sensitivity pathological signals minimal invasiveness, enabled precise microneedle sensing probes. In this review, comprehensive overview recent advancements SI‐bioelectronics provided, focus on their structures, design considerations, performances biochemical indicators, bioelectrical signals, biomechanical signals. Opportunities research such as smart medicine Internet Things also discussed, which will drive toward intelligence efficiency.
Language: Английский
Citations
1
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 273, P. 117159 - 117159
Published: Jan. 11, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125361 - 125361
Published: Feb. 17, 2025
Drug-loaded dissolvable microarray patches (MAP) have gained significant attention due to their patient-friendly, economical, and environmentally beneficial attributes. Despite extensive research advancements, only a limited number of MAP progressed clinical trials. While existing literature predominantly covers the initial stages development (e.g., manufacturing techniques, materials, design), there remains notable gap in examining an experimental design during preclinical evaluation phase undertaken inform progression studies. To address this gap, we present comprehensive review factors influencing performance research. Our in-depth analysis skin environment its implications vitro revealed that insertion methodology, media used for release permeation testing, models studies, metabolism are key need be considered. We critically assess current trends propose potential optimisations enhance efficacy biorelevance methods MAP. Additionally, vivo silico performance, underscoring promising approaches. This article aims provide insights will facilitate standardisation reliable methodologies studies drug-loaded MAP, ultimately advancing translation.
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract Traditional ophthalmic formulations are characterized by low bioavailability, short intraocular retention time, strong irritation, and failure to achieve the expected therapeutic effect due special physiological structure of eye existence many barriers. Microneedle drug delivery is a novel transdermal modality. Responsive microneedles defined as controllably releasing payloads in response stimuli, including pH levels, temperature, enzymes, reactive oxygen species (ROS), well external stimuli such magnetic fields light. In addition inheriting advantages traditional microneedles, which include enhanced targeting permeability, non‐invasiveness, painless application, integration with stimulus‐responsive materials enables responsive personalized precision process, further increases accuracy efficiency ocular treatments, making on‐demand possible. This article systematically reviews classification, mechanisms, characteristics provides detailed introduction their diagnostic applications real‐time monitoring potential diseases, aiming offer insights for treatment diseases future.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130
Published: Sept. 1, 2024
Language: Английский
Citations
3