IEEE Transactions on Molecular Biological and Multi-Scale Communications,
Год журнала:
2023,
Номер
10(1), С. 43 - 74
Опубликована: Дек. 4, 2023
Molecular
communication,
as
implied
by
its
name,
uses
molecules
information
carriers
for
communication
between
objects.
It
has
an
advantage
over
traditional
electromagnetic-wave-based
in
that
molecule-based
systems
could
be
biocompatible,
operable
challenging
environments,
and
energetically
undemanding.
Consequently,
they
are
envisioned
to
have
a
broad
range
of
applications,
such
the
Internet
Bio-Nano
Things,
targeted
drug
delivery,
agricultural
monitoring.
Despite
rapid
development
field,
with
increasing
number
theoretical
models
experimental
testbeds
established
researchers,
fundamental
aspect
field
often
been
sidelined,
namely,
nature
molecule
molecular
communication.
The
potential
exhibit
wide
properties,
making
them
require
drastically
different
treatments
when
being
modeled
experimented
upon.
Therefore,
this
paper,
we
delve
into
intricacies
commonly
used
molecules,
examining
their
physical
characteristics,
associated
systems,
applications
more
realistic
manner,
focusing
on
influence
own
properties.
Through
comprehensive
survey,
aim
offer
novel
yet
essential
perspective
thereby
bridging
current
gap
research
real-world
applications.
DNA-based
nanomaterials
have
shown
great
potential
in
numerous
applications,
thanks
to
their
unique
properties
including
DNA's
various
molecular
interactions,
programmability,
and
versatility
with
biological
modules.
Meanwhile,
the
DNA
origami
platforms
promise
creation
of
drug
carriers.
This
technique
has
paved
way
for
production
nanomachines
outstanding
performance.
Moreover,
DNA’s
encoding
capability
its
massive
parallelism
help
us
manipulate
it
computation.
The
nanotechnology
method
holds
potential,
particularly
oligonucleotide
therapeutics
that
enable
precision
medicine
cancers.
Here,
we
explore
this
context,
focusing
on
our
efforts
streamline
process.
We
then
delve
into
studies
demonstrating
application
delivering
drugs
tumor
targeting.
Following
this,
examine
dynamic
nanodevices
can
be
activated
through
binding,
environmental
stimuli,
external
field
manipulation.
Subsequently,
investigate
role
computation
logic
gates,
circuits,
data
storage,
machine
learning.
Finally,
envision
future
development
'bio-nanorobots'
based
DNA,
enabled
by
advancements
propose
combining
could
facilitate
realization
vision,
distinguishing
from
conventional
delivery
systems.
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(10), С. 1427 - 1441
Опубликована: Окт. 3, 2023
Oral
delivery
is
the
most
commonly
used
route
of
drug
administration
owing
to
good
patient
compliance.
However,
gastrointestinal
(GI)
tract
contains
multiple
physiological
barriers
that
limit
absorption
efficiency
conventional
passive
systems
resulting
in
a
low
concentration
reaching
diseased
sites.
Micro/nanorobots
can
convert
energy
self-propulsive
force,
providing
novel
platform
actively
overcome
GI
for
noninvasive
and
treatment.In
this
review,
we
first
describe
microenvironments
different
compartments
tract.
Afterward,
applications
micro/nanorobots
active
are
highlighted
discussed.
Finally,
summarize
discuss
challenges
future
prospects
further
clinical
applications.Micro/nanorobots
with
ability
autonomously
propel
themselves
load,
transport,
release
payloads
on
demand
ideal
carriers
oral
delivery.
Although
there
many
be
addressed,
have
great
potential
introduce
new
era
precision
therapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(12)
Опубликована: Янв. 17, 2024
Abstract
Microrobots
have
emerged
as
powerful
tools
for
manipulating
particles,
cells,
and
assembling
biological
tissue
structures
at
the
microscale.
However,
achieving
precise
flexible
operation
of
arbitrary‐shaped
microstructures
in
3D
space
remains
a
challenge.
In
this
study,
three
novel
methods
based
on
bubble
microrobots
are
proposed
to
enable
delicate
multifunctional
manipulation
various
microstructures.
These
include
turnover,
fixed‐point
rotation,
ejection.
By
harnessing
combined
principles
effect
heat
flow
field
surface
tension
an
optothermally
generated
bubble,
microrobot
can
perform
tasks
such
flipping
SIA
humanoid
structure,
rotating
bird‐like
launching
hollow
rocket‐like
structure.
The
multi‐mode
enables
diverse
attitude
adjustments
with
different
sizes
shapes
both
2D
spaces.
As
demonstration,
microenvironment
brain
glioblastoma
is
constructed
by
microrobot.
simplicity,
versatility,
flexibility
method
hold
great
promise
applications
micromanipulation,
assembly,
engineering.
Macromolecular Materials and Engineering,
Год журнала:
2024,
Номер
310(1)
Опубликована: Окт. 30, 2024
Abstract
The
preparation
of
resistant
ultrathin
film
(utf)
hydrogels
coated
onto
different
working
surfaces
(e.g.,
fabrics)
is
paying
increasing
attention
as
an
advantageous
strategy
for
customizing
their
resultant
properties.
More
specifically,
poly(ethylene
glycol)
(PEG)‐based
utf‐hydrogels
are
relevant
superior
biocompatibility
or
antibiofouling
However,
promoting
the
generation
dimethacrylate
(PEGDMA)
cross‐links
ideally
without
use
initiators
other
cross‐link
agents,
which
might
compromise
final
bioactivity
system,
complicated.
Moreover,
actual
synthesis
techniques
used
such
face
important
drawbacks
like
high
scale‐up
costs
geometrical
restrictions,
completely
hindering
its
technological
transfer.
Herein,
first
time
and
easy
technologically
scalable
technology
reported
direct
deposition
PEGDMA
400
substrates
based
on
atmospheric
pressure
nanosecond
pulsed
plasma
approach.
advantages
explored
discussed,
reporting
ready‐to‐use
transparent
coating
fabrics.
After
washing
samples
using
programs
a
commercial
laundry
machine,
coatings
still
well
adhered,
showing
excellent
stability.
Finally,
properties
exhaustively
characterized
in
operando
conditions
order
to
elucidate
potential
capabilities
biomedical
field.
IEEE Transactions on Molecular Biological and Multi-Scale Communications,
Год журнала:
2023,
Номер
10(1), С. 43 - 74
Опубликована: Дек. 4, 2023
Molecular
communication,
as
implied
by
its
name,
uses
molecules
information
carriers
for
communication
between
objects.
It
has
an
advantage
over
traditional
electromagnetic-wave-based
in
that
molecule-based
systems
could
be
biocompatible,
operable
challenging
environments,
and
energetically
undemanding.
Consequently,
they
are
envisioned
to
have
a
broad
range
of
applications,
such
the
Internet
Bio-Nano
Things,
targeted
drug
delivery,
agricultural
monitoring.
Despite
rapid
development
field,
with
increasing
number
theoretical
models
experimental
testbeds
established
researchers,
fundamental
aspect
field
often
been
sidelined,
namely,
nature
molecule
molecular
communication.
The
potential
exhibit
wide
properties,
making
them
require
drastically
different
treatments
when
being
modeled
experimented
upon.
Therefore,
this
paper,
we
delve
into
intricacies
commonly
used
molecules,
examining
their
physical
characteristics,
associated
systems,
applications
more
realistic
manner,
focusing
on
influence
own
properties.
Through
comprehensive
survey,
aim
offer
novel
yet
essential
perspective
thereby
bridging
current
gap
research
real-world
applications.
