Recent Advances in the Synthesis of Heterocycles via Reactions Involving Elemental Sulfur

Advanced Synthesis & Catalysis, Год журнала: 2020, Номер 362(17), С. 3448 - 3484

Опубликована: Июнь 18, 2020

Abstract It is well known that heterocycles are among the most significant molecules for everyday life, ranging from natural products and bioactive substances to functional materials. This review will focus on synthesis of by reactions involving elemental sulfur published 2017 until now. magnified image

Язык: Английский

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Ketones as strategic building blocks for the synthesis of natural product-inspired compounds

Chemical Society Reviews, Год журнала: 2022, Номер 51(10), С. 4094 - 4120

Опубликована: Янв. 1, 2022

This review explores and summarises synthetic methods that may be used to prepare heterocyclic ring systems from non-activated ketones, considers their potential value towards the synthesis of natural product-inspired compound collections.

Язык: Английский

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Recent advances in the synthesis of imidazoles

Organic & Biomolecular Chemistry, Год журнала: 2020, Номер 18(21), С. 3950 - 3964

Опубликована: Янв. 1, 2020

The review highlights the recent advances (2018-present) in regiocontrolled synthesis of substituted imidazoles.

Язык: Английский

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S₈-Catalyzed triple cleavage of bromodifluoro compounds for the assembly of N-containing heterocycles

Chemical Science, Год журнала: 2019, Номер 10(28), С. 6828 - 6833

Опубликована: Янв. 1, 2019

An unprecedented S₈-catalyzed selective triple-cleavage of bromodifluoroacetamides is disclosed for the first time.

Язык: Английский

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Synthesis of o-Arylenediamines through Elemental Sulfur-Promoted Aerobic Dehydrogenative Aromatization of Cyclohexanones with Arylamines

Organic Letters, Год журнала: 2018, Номер 20(17), С. 5470 - 5473

Опубликована: Авг. 21, 2018

Herein, the first elemental sulfur-promoted aerobic dehydrogenative aromatization of cyclohexanones is described that provides novel access to synthetically useful o-arylenediamines. This protocol complements previous palladium- and iodine-catalyzed diarylamine formation from anilines.

Язык: Английский

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Transition-metal-free selective pyrimidines and pyridines formation from aromatic ketones, aldehydes and ammonium salts

Green Chemistry, Год журнала: 2019, Номер 21(19), С. 5201 - 5206

Опубликована: Янв. 1, 2019

Pyrimidines and pyridines could be selectively formed from aromatic ketones, aldehydes ammonium salts under transition-metal-free conditions.

Язык: Английский

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Elemental Sulfur Promoted Cyclization of Aryl Hydrazones and Aryl Isothiocyanates Yielding 2-Imino-1,3,4-thiadiazoles

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(5), С. 3202 - 3210

Опубликована: Фев. 8, 2024

We report a method for using elemental sulfur to facilitate the cyclization of aryl hydrazones and isothiocyanates, affording biorelated 2-imino-1,3,4-thiadiazoles. Reactions progressed in presence sulfur, N-methylmorpholine base, DMSO solvent, while were tolerant wide range functionalities including halogen, nitro, cyano, methylsulfonyl, heterocyclic groups. The appears offer general pathway simple, cheap, stable reagents afford triaryl-substituted 2-imino-1,3,4-thiadiazoles under relatively mild conditions.

Язык: Английский

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1,2-Diethoxyethane catalyzed oxidative cleavage of gem-disubstituted aromatic alkenes to ketones under minimal solvent conditions

Chinese Chemical Letters, Год журнала: 2020, Номер 31(7), С. 1868 - 1872

Опубликована: Янв. 17, 2020

Язык: Английский

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Metal-Free Atom-Economical Synthesis of Tetra-Substituted Imidazoles via Flavin-Iodine Catalyzed Aerobic Cross-Dehydrogenative Coupling of Amidines and Chalcones

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(15), С. 10372 - 10376

Опубликована: Июль 15, 2022

Herein, we demonstrated the oxidative cross-dehydrogenative coupling between amidines and chalcones catalyzed by flavin iodine. The riboflavin-iodine catalytic system played multiple roles in substrate- O2-activation, enabling facile atom-economical synthesis of tetra-substituted imidazoles good yields (60-87%). This metal-free reaction consumed only 1 equiv molecular oxygen generated 2 environmentally benign H2O as byproduct.

Язык: Английский

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I2-DMSO-Promoted Direct Synthesis of Substituted Imidazoles from Styrenes and Benzylamines under Solvent-Free Conditions

Synthesis, Год журнала: 2022, Номер 55(05), С. 846 - 856

Опубликована: Окт. 12, 2022

Abstract A novel and efficient method has been developed for the direct synthesis of substituted imidazoles through reaction styrenes benzylamines with assistance I2-DMSO concerted system. The reactions proceed efficiently under open air solvent-free conditions to afford a wide variety in good yields. productive large-scale also performed target highly heterocyclic motifs. present protocol offers metal- process, mild conditions, easily accessible reactants, operational simplicity achieve an assembly N-heterocyclic compounds.

Язык: Английский

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