Heliyon,
Год журнала:
2025,
Номер
11(2), С. e41959 - e41959
Опубликована: Янв. 1, 2025
This
study
investigates
the
interactive
effects
of
food
type,
exposure
time,
and
experimental
dosages
on
biochemical
insecticidal
responses
Tribolium
castaneum
(Herbst)
to
toxic
three
botanicals.
The
botanicals
[Piper
guineense
(PG),
Cinnamomum
verum
(CV),
Syzygium
aromaticum
(SA)]
were
applied
individually
in
binary
combinations
(PG
+
SA,
PG
CV,
SA
CV).
Beetles
reared
for
two
generations
wheat
yam
flour
prior
insecticide
exposure.
specific
activities
α-amylase,
alkaline
phosphatase
(AKP),
acid
(ACP),
acetylcholinesterase
(AChE),
glutathione
S-transferase
(GST)
also
determined.
Generally,
T.
each
botanical
extract
their
varied
with
type
host
used
rearing
beetles,
dosage,
time
extracts.
main
factors
(i.e.
food,
dosage)
two-way
interactions
(F∗D,
F∗T
D∗T)
significantly
(p
<
0.05)
influenced
mortality
response
beetles.
According
LD50,
LD95,
LT50
values,
all
extracts
generally
more
beetles
fed
than
those
flour.
given
showed
mixture
CV
Except
which
had
a
synergistic
effect
yam-reared
castaneum,
mixtures
antagonistic
beetles'
rate.
Irrespective
higher
AKP,
ACP
was
recorded
exposed
alone
EA
combination
relative
control.
demonstrates
valuable
insights
needed
possible
development
targeted
sustainable
strategies
managing
infesting
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
313, С. 102848 - 102848
Опубликована: Фев. 3, 2023
As
nanocarriers
(NCs)
can
improve
the
solubility
of
drugs,
prevent
their
degradation
by
gastrointestinal
(GI)
enzymes
and
promote
transport
across
mucus
gel
layer
absorption
membrane,
oral
bioavailability
these
drugs
be
substantially
enhanced.
All
properties
NCs
including
self-emulsifying
drug
delivery
systems
(SEDDS),
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers
(NLCs),
liposomes,
polymeric
nanoparticles,
inorganic
micelles
depend
mainly
on
surface
chemistry.
In
particular,
interaction
with
food,
digestive
enzymes,
bile
salts
electrolytes,
diffusion
behaviour
fate
membrane
are
determined
surface.
Bioinert
surfaces
limiting
interactions
fluid
content
as
well
mucus,
adhesive
providing
an
intimate
contact
GI
mucosa
enhancing
designed.
Furthermore,
charge
converting
shifting
zeta
potential
from
negative
to
positive
directly
at
a
targeted
release
advantageous.
addition
passive
surfaces,
even
active
cleaving
glycoproteins
way
through
created.
Within
this
review,
we
provide
overview
different
discuss
impact
performance
in
tract.
Abstract
Aggregate‐level
photodynamic
therapy
(PDT)
has
attracted
significant
interest
and
driven
substantial
advances
in
multifunction
phototheranostic
platforms.
As
exemplified
by
two
typical
instances
of
aggregation‐caused
quenching
reactive
oxygen
species
(ROS)
aggregation‐induced
generation
ROS,
the
aggregation
effect
plays
a
role
on
ROS
photosensitizers
(PSs),
which
is
worthy
in‐depth
exploration
full
utilization.
However,
contrast
to
well‐developed
researches
luminescence,
studies
concerning
are
currently
relatively
nascent
disjointed
stage,
lacking
guidance
from
firmly
established
research
paradigm.
To
advance
this
regard,
review
aims
at
providing
consolidated
overview
fundamental
principles
status
effects
generation.
Here,
can
be
organized
into
main
facets.
One
involves
comparison
between
isolated
state
aggregated
state,
mainly
conducted
methods
changing
solvent
environments
adding
adjuvants
given
solvent.
The
other
underscores
distinctions
different
aggregate
states,
consisting
three
parts,
namely
within
same
or
categories
based
classification
single‐component
multicomponent
aggregates.
In
endeavor,
we
will
present
our
views
current
methodologies
that
explore
how
affects
highlight
design
strategies
leverage
optimize
PS
regiments.
We
aspire
propel
advancement
platforms
accelerate
clinical
implementation
precision
medicine,
inspire
more
contributions
aggregate‐level
photophysics
photochemistry,
pushing
science
materials
forward.
ACS Nano,
Год журнала:
2024,
Номер
18(27), С. 17837 - 17851
Опубликована: Июнь 28, 2024
Currently,
specific
cancer-responsive
fluorogenic
probes
with
activatable
imaging
and
therapeutic
functionalities
are
in
great
demand
the
accurate
diagnostics
efficient
therapy
of
malignancies.
Herein,
an
all-in-one
strategy
is
presented
to
realize
fluorescence
(FL)
imaging-guided
synergetic
chemodynamic–photodynamic
cancer
by
using
a
multifunctional
alkaline
phosphatase
(ALP)-response
aggregation-induced
emission
(AIE)
probe,
TPE-APP.
By
responding
abnormal
expression
levels
ALP
biomarker
cells,
phosphate
groups
on
AIE
probe
selectively
hydrolyzed,
accompanied
situ
formation
strong
emissive
aggregates
for
discriminative
cell
over
normal
cells
highly
active
quinone
methide
species
robust
activities.
Consequently,
activated
can
efficiently
destroy
membranes
lead
death
within
30
min.
A
superior
efficacy
ablation
demonstrated
vitro
vivo.
The
cancer-associated
response-derived
FL
synergistic
expected
provide
promising
avenue
precise
image-guided
therapy.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Traditional
polymer
systems
often
rely
on
toxic
initiators
or
catalysts
for
cross-linking,
posing
significant
safety
risks.
For
bone
tissue
engineering,
another
issue
is
that
the
scaffolds
take
a
longer
time
to
degrade,
inconsistent
with
formation
pace.
Here,
we
developed
an
enzyme-responsive
biodegradable
poly(propylene
fumarate)
(PPF)
and
polycaprolactone
(PCL)
polyphosphoester
(PPE)
dendrimer
cross-linked
utilizing
click
chemistry
(EnzDeg-click-PFCLPE
scaffold)
enhanced
biocompatibility
degradation.
The
strain-promoted
alkyne–azide
cycloaddition
(SPAAC)
offers
high
efficiency
without
harmful
agents.
polyphosphoesters
render
cleavage
responsive
alkaline
phosphatase
(ALP)
enzyme
in
formation,
ensuring
facilitated
scaffold
biodegradation.
vitro
testing
confirmed
biocompatibility,
degradation,
capability
support
stem
cell
differentiation.
Further
vivo
implantation
rat
demonstrated
regeneration
integration.
In
summary,
this
system
combining
ALP-responsive
biodegradation
ensures
initial
facilitates
degradation
synchronized
natural
healing
process.
Abstract
The
past
two
decades
have
witnessed
a
rapid
progress
in
the
development
of
surface
charge‐reversible
nanoparticles
(NPs)
for
drug
delivery
and
diagnosis.
These
NPs
are
able
to
elegantly
address
polycation
dilemma.
Converting
their
charge
from
negative/neutral
positive
at
target
site,
they
can
substantially
improve
drugs
diagnostic
agents.
By
specific
stimuli
like
shift
pH
redox
potential,
enzymes,
or
exogenous
such
as
light
heat,
reversal
NP
be
achieved
site.
activated
enhances
adhesion
cells
facilitates
cellular
uptake,
endosomal
escape,
mitochondrial
targeting.
Because
these
properties,
efficacy
incorporated
well
sensitivity
agents
essentially
enhanced.
Furthermore,
shown
overcome
biofilm
formed
by
pathogenic
bacteria
shuttle
antibiotics
directly
cell
membrane
microorganisms.
In
this
review,
up‐to‐date
design
emerging
applications
diagnosis
highlighted.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(23), С. 27600 - 27611
Опубликована: Май 30, 2023
We
report
for
the
first
time
controlled
drug
release
from
a
nanoscale
Zr-based
metal-organic
framework
(MOF),
UiO-66,
in
presence
of
enzyme
alkaline
phosphatase
(ALP).
This
unprecedented
reactivity
was
possible
thanks
to
prior
functionalization
MOF
with
N3-PEG-PO3
ligands,
which
were
designed
three
specific
aims:
(1)
impart
colloidal
stability
phosphate-containing
media;
(2)
endow
multifunctionality
azide
groups
covalent
attachment
an
imaging
agent
by
click-chemistry;
and
(3)
confer
stimuli-responsive
properties,
specifically
selective
doxorubicin
triggered
enzymatic
activity
ALP.
Cell
studies
revealed
that
N3-(PEG)20-PO3
ligands
improved
their
intracellular
led
sustained
compared
bare
MOF.
More
importantly,
enhanced
observed
cells
higher
expression
ALP
genes
(HeLa
versus
MDA-MB-231
MCF7),
confirming
ALP-responsiveness
system
inside
living
cells.
