Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742652 - 742652
Published: May 1, 2025
Language: Английский
Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 313, P. 102848 - 102848
Published: Feb. 3, 2023
As nanocarriers (NCs) can improve the solubility of drugs, prevent their degradation by gastrointestinal (GI) enzymes and promote transport across mucus gel layer absorption membrane, oral bioavailability these drugs be substantially enhanced. All properties NCs including self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLNs), nanostructured carriers (NLCs), liposomes, polymeric nanoparticles, inorganic micelles depend mainly on surface chemistry. In particular, interaction with food, digestive enzymes, bile salts electrolytes, diffusion behaviour fate membrane are determined surface. Bioinert surfaces limiting interactions fluid content as well mucus, adhesive providing an intimate contact GI mucosa enhancing designed. Furthermore, charge converting shifting zeta potential from negative to positive directly at a targeted release advantageous. addition passive surfaces, even active cleaving glycoproteins way through created. Within this review, we provide overview different discuss impact performance in tract.
Language: Английский
Citations
55
Aggregate, Journal Year: 2024, Volume and Issue: 5(4)
Published: March 10, 2024
Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.
Language: Английский
Citations
38
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124211 - 124211
Published: May 13, 2024
Language: Английский
Citations
16
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Traditional polymer systems often rely on toxic initiators or catalysts for cross-linking, posing significant safety risks. For bone tissue engineering, another issue is that the scaffolds take a longer time to degrade, inconsistent with formation pace. Here, we developed an enzyme-responsive biodegradable poly(propylene fumarate) (PPF) and polycaprolactone (PCL) polyphosphoester (PPE) dendrimer cross-linked utilizing click chemistry (EnzDeg-click-PFCLPE scaffold) enhanced biocompatibility degradation. The strain-promoted alkyne–azide cycloaddition (SPAAC) offers high efficiency without harmful agents. polyphosphoesters render cleavage responsive alkaline phosphatase (ALP) enzyme in formation, ensuring facilitated scaffold biodegradation. vitro testing confirmed biocompatibility, degradation, capability support stem cell differentiation. Further vivo implantation rat demonstrated regeneration integration. In summary, this system combining ALP-responsive biodegradation ensures initial facilitates degradation synchronized natural healing process.
Language: Английский
Citations
2
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215336 - 215336
Published: July 16, 2023
Language: Английский
Citations
41
Small, Journal Year: 2023, Volume and Issue: 20(3)
Published: Sept. 7, 2023
Abstract The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address polycation dilemma. Converting their charge from negative/neutral positive at target site, they can substantially improve drugs diagnostic agents. By specific stimuli like shift pH redox potential, enzymes, or exogenous such as light heat, reversal NP be achieved site. activated enhances adhesion cells facilitates cellular uptake, endosomal escape, mitochondrial targeting. Because these properties, efficacy incorporated well sensitivity agents essentially enhanced. Furthermore, shown overcome biofilm formed by pathogenic bacteria shuttle antibiotics directly cell membrane microorganisms. In this review, up‐to‐date design emerging applications diagnosis highlighted.
Language: Английский
Citations
35
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 168, P. 117335 - 117335
Published: Sept. 27, 2023
Language: Английский
Citations
31
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(23), P. 27600 - 27611
Published: May 30, 2023
We report for the first time controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in presence of enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible thanks to prior functionalization MOF with N3-PEG-PO3 ligands, which were designed three specific aims: (1) impart colloidal stability phosphate-containing media; (2) endow multifunctionality azide groups covalent attachment an imaging agent by click-chemistry; and (3) confer stimuli-responsive properties, specifically selective doxorubicin triggered enzymatic activity ALP. Cell studies revealed that N3-(PEG)20-PO3 ligands improved their intracellular led sustained compared bare MOF. More importantly, enhanced observed cells higher expression ALP genes (HeLa versus MDA-MB-231 MCF7), confirming ALP-responsiveness system inside living cells.
Language: Английский
Citations
25
ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17837 - 17851
Published: June 28, 2024
Currently, specific cancer-responsive fluorogenic probes with activatable imaging and therapeutic functionalities are in great demand the accurate diagnostics efficient therapy of malignancies. Herein, an all-in-one strategy is presented to realize fluorescence (FL) imaging-guided synergetic chemodynamic–photodynamic cancer by using a multifunctional alkaline phosphatase (ALP)-response aggregation-induced emission (AIE) probe, TPE-APP. By responding abnormal expression levels ALP biomarker cells, phosphate groups on AIE probe selectively hydrolyzed, accompanied situ formation strong emissive aggregates for discriminative cell over normal cells highly active quinone methide species robust activities. Consequently, activated can efficiently destroy membranes lead death within 30 min. A superior efficacy ablation demonstrated vitro vivo. The cancer-associated response-derived FL synergistic expected provide promising avenue precise image-guided therapy.
Language: Английский
Citations
15
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 112144 - 112144
Published: Feb. 1, 2024
Language: Английский
Citations
11