Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Год журнала: 2021, Номер 15(12), С. 18895 - 18930

Опубликована: Дек. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Язык: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Год журнала: 2021, Номер 50(15), С. 8669 - 8742

Опубликована: Янв. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Язык: Английский

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Medical Micro/Nanorobots in Precision Medicine

Advanced Science, Год журнала: 2020, Номер 7(21)

Опубликована: Окт. 4, 2020

Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization these robotic platforms has led numerous applications that leverages precision medicine. In this review, current trends micro nanorobotics for therapy, surgery, diagnosis, imaging are discussed. The use nanorobots still faces technical, regulatory, market challenges their widespread clinical settings. Nevertheless, recent translations from proof concept vivo studies demonstrate potential toward

Язык: Английский

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Light‐Responsive Inorganic Biomaterials for Biomedical Applications

Advanced Science, Год журнала: 2020, Номер 7(17)

Опубликована: Июль 17, 2020

Abstract Light‐responsive inorganic biomaterials are an emerging class of materials used for developing noninvasive, noncontact, precise, and controllable medical devices in a wide range biomedical applications, including photothermal therapy, photodynamic drug delivery, regenerative medicine. Herein, is discussed, carbon‐based nanomaterials, gold nanoparticles, graphite carbon nitride, transition metal dichalcogenides, up‐conversion nanoparticles that the design light‐responsive devices. The importance these explored to light‐guided nanovehicle, modulate cellular behavior, as well regulate extracellular microenvironments. Additionally, future perspectives on clinical use highlighted.

Язык: Английский

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Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Materials Today Bio, Год журнала: 2022, Номер 14, С. 100223 - 100223

Опубликована: Фев. 21, 2022

Inflammatory arthritis is a major cause of disability in the elderly. This condition causes joint pain, loss function, and deterioration quality life, mainly due to osteoarthritis (OA) rheumatoid (RA). Currently, available treatment options for inflammatory include anti-inflammatory medications administered via oral, topical, or intra-articular routes, surgery, physical rehabilitation. Novel alternative approaches managing arthritis, so far, remain grand challenge owing catastrophic financial burden insignificant therapeutic benefit. In view non-targeted systemic cytotoxicity limited bioavailability drug therapies, concern establish stimuli-responsive delivery systems using nanomaterials with on-off switching potential biomedical applications. review summarizes advanced applications triggerable dependent on various internal stimuli (including reduction-oxidation (redox), pH, enzymes) external temperature, ultrasound (US), magnetic, photo, voltage, mechanical friction). The also explores progress challenges use manage based pathological changes, including cartilage degeneration, synovitis, subchondral bone destruction. Exposure appropriate induced by such histopathological alterations can trigger release medications, imperative joint-targeted arthritis.

Язык: Английский

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On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Bone Research, Год журнала: 2021, Номер 9(1)

Опубликована: Фев. 11, 2021

Abstract The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as population ages. Traditionally, smart have been thought those respond stimuli. However, continuous evolution field warrants a fresh look at concept smartness biomaterials. This review presents redefinition term “Smart Biomaterial” discusses recent advances in applications tissue regeneration. To clarify use “smart biomaterials”, we propose four degrees according level interaction with bio-environment biological/cellular responses they elicit, defining these materials inert, active, responsive, autonomous. Then, present an up-to-date survey tissues, based on materials’ (external internal stimuli) their immune-modulatory Finally, discuss limitations obstacles translation from basic research (bench) clinical utilization is required development clinically relevant technologies.

Язык: Английский

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Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials

Trends in Food Science & Technology, Год журнала: 2021, Номер 109, С. 413 - 434

Опубликована: Янв. 12, 2021

Язык: Английский

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Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Advanced Healthcare Materials, Год журнала: 2021, Номер 11(2)

Опубликована: Ноя. 9, 2021

Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.

Язык: Английский

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Photo‐Reduction with NIR Light of Nucleus‐Targeting Pt^IVNanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(20)

Опубликована: Фев. 25, 2022

Abstract The development of Pt IV prodrugs which are selectively reduced within cancerous cells into their II therapeutically active species has received increasing attention the last decade. Despite recent research progress, majority investigated compounds excited using ultraviolet or blue light. As light penetration depth is low at these wavelengths, treatment deep‐seated large tumors limited. To overcome this limitation, herein, example ‐functionalized nanoparticles that could be NIR region 808 nm reported. polymer backbone can self‐assemble was functionalized with complexes for chemotherapy, photosensitizers photodynamic immunotherapy, and nucleus/cancer‐targeting peptides. Upon irradiation, center to axially coordinated ligands released, presenting a multimodal treatment. While accumulating in tumorous tissue, demonstrated ability eradicate triple‐negative breast cancer tumor inside mouse model.

Язык: Английский

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