International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100265 - 100265
Published: June 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(12), P. 18895 - 18930
Published: Dec. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(15), P. 8669 - 8742
Published: Jan. 1, 2021
Inorganic
nanomaterials
that
have
inherently
exceptional
physicochemical
properties
(e.g.,
catalytic,
optical,
thermal,
electrical,
or
magnetic
performance)
can
provide
desirable
functionality
drug
delivery,
diagnostics,
imaging,
therapy)
considerable
potential
for
application
in
the
field
of
biomedicine.
However,
toxicity
be
caused
by
long-term,
non-specific
accumulation
these
inorganic
healthy
tissues,
preventing
their
large-scale
clinical
utilization.
Over
past
several
decades,
emergence
biodegradable
and
clearable
has
offered
to
prevent
such
long-term
toxicity.
In
addition,
a
comprehensive
understanding
design
metabolic
pathways
within
body
is
essential
enabling
expansion
theranostic
applications
various
diseases
advancing
trials.
Thus,
it
critical
importance
develop
biomedical
applications.
This
review
systematically
summarizes
recent
progress
nanomaterials,
particularly
cancer
theranostics
other
disease
therapies.
The
future
prospects
opportunities
this
rapidly
growing
are
also
discussed.
We
believe
timely
will
stimulate
guide
additional
in-depth
studies
area
nanomedicine,
as
rapid
vivo
clearance
degradation
likely
prerequisite
translation
with
unique
functionality.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(21)
Published: Oct. 4, 2020
Advances
in
medical
robots
promise
to
improve
modern
medicine
and
the
quality
of
life.
Miniaturization
these
robotic
platforms
has
led
numerous
applications
that
leverages
precision
medicine.
In
this
review,
current
trends
micro
nanorobotics
for
therapy,
surgery,
diagnosis,
imaging
are
discussed.
The
use
nanorobots
still
faces
technical,
regulatory,
market
challenges
their
widespread
clinical
settings.
Nevertheless,
recent
translations
from
proof
concept
vivo
studies
demonstrate
potential
toward
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
14, P. 100223 - 100223
Published: Feb. 21, 2022
Inflammatory
arthritis
is
a
major
cause
of
disability
in
the
elderly.
This
condition
causes
joint
pain,
loss
function,
and
deterioration
quality
life,
mainly
due
to
osteoarthritis
(OA)
rheumatoid
(RA).
Currently,
available
treatment
options
for
inflammatory
include
anti-inflammatory
medications
administered
via
oral,
topical,
or
intra-articular
routes,
surgery,
physical
rehabilitation.
Novel
alternative
approaches
managing
arthritis,
so
far,
remain
grand
challenge
owing
catastrophic
financial
burden
insignificant
therapeutic
benefit.
In
view
non-targeted
systemic
cytotoxicity
limited
bioavailability
drug
therapies,
concern
establish
stimuli-responsive
delivery
systems
using
nanomaterials
with
on-off
switching
potential
biomedical
applications.
review
summarizes
advanced
applications
triggerable
dependent
on
various
internal
stimuli
(including
reduction-oxidation
(redox),
pH,
enzymes)
external
temperature,
ultrasound
(US),
magnetic,
photo,
voltage,
mechanical
friction).
The
also
explores
progress
challenges
use
manage
based
pathological
changes,
including
cartilage
degeneration,
synovitis,
subchondral
bone
destruction.
Exposure
appropriate
induced
by
such
histopathological
alterations
can
trigger
release
medications,
imperative
joint-targeted
arthritis.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(17)
Published: July 17, 2020
Abstract
Light‐responsive
inorganic
biomaterials
are
an
emerging
class
of
materials
used
for
developing
noninvasive,
noncontact,
precise,
and
controllable
medical
devices
in
a
wide
range
biomedical
applications,
including
photothermal
therapy,
photodynamic
drug
delivery,
regenerative
medicine.
Herein,
is
discussed,
carbon‐based
nanomaterials,
gold
nanoparticles,
graphite
carbon
nitride,
transition
metal
dichalcogenides,
up‐conversion
nanoparticles
that
the
design
light‐responsive
devices.
The
importance
these
explored
to
light‐guided
nanovehicle,
modulate
cellular
behavior,
as
well
regulate
extracellular
microenvironments.
Additionally,
future
perspectives
on
clinical
use
highlighted.
Bone Research,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: Feb. 11, 2021
Abstract
The
demand
for
biomaterials
that
promote
the
repair,
replacement,
or
restoration
of
hard
and
soft
tissues
continues
to
grow
as
population
ages.
Traditionally,
smart
have
been
thought
those
respond
stimuli.
However,
continuous
evolution
field
warrants
a
fresh
look
at
concept
smartness
biomaterials.
This
review
presents
redefinition
term
“Smart
Biomaterial”
discusses
recent
advances
in
applications
tissue
regeneration.
To
clarify
use
“smart
biomaterials”,
we
propose
four
degrees
according
level
interaction
with
bio-environment
biological/cellular
responses
they
elicit,
defining
these
materials
inert,
active,
responsive,
autonomous.
Then,
present
an
up-to-date
survey
tissues,
based
on
materials’
(external
internal
stimuli)
their
immune-modulatory
Finally,
discuss
limitations
obstacles
translation
from
basic
research
(bench)
clinical
utilization
is
required
development
clinically
relevant
technologies.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
11(2)
Published: Nov. 9, 2021
Abstract
Traditional
tumor
treatments,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
and
photothermal
are
developed
used
to
treat
different
types
of
cancer.
Recently,
chemodynamic
therapy
(CDT)
has
been
emerged
as
a
novel
cancer
therapeutic
strategy.
CDT
utilizes
Fenton
or
Fenton‐like
reaction
generate
highly
cytotoxic
hydroxyl
radicals
(•OH)
from
endogenous
hydrogen
peroxide
(H
2
O
)
kill
cells,
which
displays
promising
potentials
for
treatment.
However,
the
low
catalytic
efficiency
off‐target
side
effects
limit
biomedical
application
CDT.
In
this
regard,
various
strategies
implemented
potentiate
against
tumor,
retrofitting
microenvironment
(e.g.,
increasing
H
level,
decreasing
reductive
substances,
reducing
pH),
enhancing
nanocatalysts,
other
strategies.
This
review
aims
summarize
development
these
recent
progresses
nanocatalyst‐mediated
antitumor
application.
The
future
trend
challenges
also
discussed.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(20)
Published: Feb. 25, 2022
Abstract
The
development
of
Pt
IV
prodrugs
which
are
selectively
reduced
within
cancerous
cells
into
their
II
therapeutically
active
species
has
received
increasing
attention
the
last
decade.
Despite
recent
research
progress,
majority
investigated
compounds
excited
using
ultraviolet
or
blue
light.
As
light
penetration
depth
is
low
at
these
wavelengths,
treatment
deep‐seated
large
tumors
limited.
To
overcome
this
limitation,
herein,
example
‐functionalized
nanoparticles
that
could
be
NIR
region
808
nm
reported.
polymer
backbone
can
self‐assemble
was
functionalized
with
complexes
for
chemotherapy,
photosensitizers
photodynamic
immunotherapy,
and
nucleus/cancer‐targeting
peptides.
Upon
irradiation,
center
to
axially
coordinated
ligands
released,
presenting
a
multimodal
treatment.
While
accumulating
in
tumorous
tissue,
demonstrated
ability
eradicate
triple‐negative
breast
cancer
tumor
inside
mouse
model.
