ACS Nano,
Год журнала:
2022,
Номер
16(1), С. 951 - 962
Опубликована: Янв. 3, 2022
Electrodynamic
therapy
(EDT)
combining
nanotechnology
with
electronic
current
was
used
in
this
study
to
generate
highly
cytotoxic
oxidative
hydroxyl
radicals
(·OH)
for
tumor
destruction.
However,
increasing
evidence
suggests
that
EDT
treatment
alone
one
time
still
faces
great
challenges
achieving
long-term
suppression
an
immunosuppressive
environment,
which
would
raise
the
risk
of
later
recurrence.
Benefitting
from
marvelous
potential
reactive
oxygen
species
(ROS)-mediated
dynamic
therapies
immunocombination
due
their
immunogenic
cell
death
(ICD)
effect,
a
glutamine
antagonist
6-diazo-5-oxo-l-norleucine
(DON)-loaded
nanocarrier
(Pt-Pd@DON)
designed
combination
(EDT
and
immunotherapy)
against
recurrence
metastasis.
The
protective
immune
response
motivated
tumors
by
joint
functions
ICD
CD8+
T
infiltration
promoted
DON.
A
therapeutic
efficacy
has
been
demonstrated
primary
metastatic
models,
respectively.
This
provided
effective
thought
way
clinical
treatment.
Theranostics,
Год журнала:
2021,
Номер
11(13), С. 6370 - 6392
Опубликована: Янв. 1, 2021
As
one
of
the
most
important
cancer
treatment
strategies,
conventional
chemotherapy
has
substantial
side
effects
and
leads
easily
to
failure.
Therefore,
exploring
developing
more
efficient
methods
enhance
is
an
urgently
problem
that
must
be
solved.
With
development
nanotechnology,
nanomedicine
showed
a
good
application
prospect
in
improving
chemotherapy.
In
this
review,
we
aim
present
discussion
on
significant
research
progress
for
enhanced
First,
increased
enrichment
drugs
tumor
tissues
relying
different
targeting
ligands
promoting
tissue
penetration
are
summarized.
Second,
specific
subcellular
organelle-targeted
discussed.
Next,
combinational
strategies
reverse
multidrug
resistance
(MDR)
improve
effective
intracellular
concentration
therapeutics
Furthermore,
advantages
combination
therapy
emphasized.
Finally,
discuss
major
problems
facing
therapeutic
chemotherapy,
propose
possible
future
directions
field.
The
field
of
nanozymes
has
developed
rapidly
over
the
past
decade.
Among
various
oxidoreductases
mimics,
catalase
(CAT)-like
nanozyme,
acting
as
an
essential
part
regulation
reactive
oxygen
species
(ROS),
attracted
extensive
research
interest
in
recent
years.
However,
CAT-like
are
not
well
discussed
other
such
peroxidase
(POD)-like
nanozymes,
etc.
Compared
with
natural
or
artificial
CAT
enzymes,
have
unique
properties
low
cost,
size-dependent
properties,
high
catalytic
activity
and
stability,
easy
surface
modification,
etc.,
which
make
them
widely
used
fields,
especially
tumor
therapy
disease
treatment.
Consequently,
there
is
a
great
requirement
to
systematic
discussion
on
nanozymes.
In
this
review,
some
key
aspects
deeply
summarized
as:
1)
Typical
classified
by
different
nanomaterials;
2)
mechanisms
proposed
experimental
theoretical
studies;
3)
Extensive
applications
regard
therapy,
cytoprotection
sensing.
Therefore,
it
prospected
that
review
will
contribute
further
design
optimize
their
much
higher
efficiency
than
before.
Cancer
immunotherapy
has
achieved
promising
clinical
progress
over
the
recent
years
for
its
potential
to
treat
metastatic
tumors
and
inhibit
their
recurrences
effectively.
However,
low
patient
response
rates
dose-limiting
toxicity
remain
as
major
dilemmas
immunotherapy.
Stimuli-responsive
nanoparticles
(srNPs)
combined
with
offer
possibility
amplify
anti-tumor
immune
responses,
where
weak
acidity,
high
concentration
of
glutathione,
overexpressions
enzymes,
reactive
oxygen
species,
external
stimuli
in
act
triggers
controlled
drug
release.
This
review
highlights
design
srNPs
based
on
tumor
microenvironment
and/or
combine
different
drugs,
especially
immunoregulatory
agents,
which
eventually
realize
synergistic
malignant
primary
or
acquire
a
long-term
memory
prevent
recurrence.
The
authors
hope
that
this
can
provide
theoretical
guidance
construction
transformation
smart
delivery
cancer
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(33)
Опубликована: Июнь 16, 2021
Abstract
Efficient
antimicrobials
are
urgently
needed
for
the
treatment
of
bacterial
biofilms
due
to
their
resistance
traditional
drugs.
Photodynamic
therapy
(PDT)
is
a
new
strategy
that
has
been
used
combat
bacteria
and
biofilms.
Cationic
photosensitizers,
particularly
cationic
photodynamic
nanoagents,
usually
chosen
enhance
antimicrobial
activity.
However,
positively
charged
nanoparticles
(NPs)
beneficial
cellular
internalization,
which
causes
increased
cell
cytotoxicity.
Herein,
pH‐sensitive
nanosystem
designed.
Rose
Bengal
(RB)
polydopamine
(PDA)
NPs
decorated
in
layer‐by‐layer
fashion
with
polymyxin
B
(PMB)
gluconic
acid
(GA)
generate
functionally
adaptive
(RB@PMB@GA
NPs).
RB@PMB@GA
remain
negative
at
physiological
pH
exhibit
good
biocompatibility.
When
exposed
an
acidic
infectious
environment,
surface
charge
is,
turn,
as
result
electrostatic
interactions.
This
conversion
allows
effectively
bind
surfaces
photoinactivation
efficiency
against
gram‐negative
bacteria.
Most
importantly,
biofilm
penetration
eradication
under
conditions.
Furthermore,
efficiently
eliminate
infections
vivo.
study
provides
promising
safely
treating
biofilm‐associated
Abstract
The
combination
of
chemotherapy
and
photodynamic
therapy
(PDT)
has
promising
potential
in
the
synergistic
treatment
cancer.
However,
are
impeded
by
uncontrolled
chemotherapeutics
release
behavior,
targeting
deficiencies,
hypoxia‐associated
poor
PDT
efficacy
solid
tumors.
Here,
a
platinum
nanozyme
(PtNP)
loaded
reactive
oxygen
species
(ROS)‐responsive
prodrug
nanoparticle
(CPT‐TK‐HPPH/Pt
NP)
is
created
to
overcome
these
limitations.
ROS‐responsive
consists
thioketal
bond
linked
with
camptothecin
(CPT)
photosensitizer‐2‐(1‐hexyloxyethyl)‐2‐devinyl
pyropheophorbide‐a
(HPPH).
PtNP
CPT‐TK‐HPPH/Pt
NP
can
efficiently
catalyze
decomposition
hydrogen
peroxide
(H
2
O
)
into
relieve
hypoxia.
production
satisfy
consumption
HPPH
under
660
nm
laser
irradiation
attain
on‐demand
CPT
ensure
enhanced
therapy.
As
tumor
diagnosis
agent,
results
photoacoustic
imaging
fluorescence
for
exhibit
desirable
long
circulation
vivo
targeting.
NPs
effectively
inhibit
proliferation
growth
vitro
vivo.
NP,
its
excellent
drug
behavior
efficiency
serve
as
new
cancer
theranostic
will
further
promote
research
chemophotodynamic
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(27), С. 30480 - 30492
Опубликована: Апрель 25, 2022
Microenvironment-responsive
hydrogels
present
high
potential
in
treating
refractory
wounds
due
to
their
capability
of
on-demand
drug
release.
In
this
study,
a
specially
designed
hydrogel
with
smart
targeting
wound
characteristics
was
treat
chronically
infected
diabetic
wounds.
Aminated
gelatin
reacted
oxidized
dextran,
forming
cross-linked
dynamic
Schiff
base,
which
is
sensitive
the
low-pH
environment
Nano-ZnO
loaded
into
for
killing
microbes.
A
Paeoniflorin-encapsulated
micelle
ROS-responsive
property
fixed
skeleton
via
base
bond
low-pH-
and
ROS-stimulated
angiogenic
activity.
The
sequential
responsiveness
novel
enabled
rescue
deleterious
microenvironment
This
highly
biocompatible
demonstrated
antibacterial
abilities
vitro
significantly
promoted
healing
hemostatic,
microbe
killing,
activities.
microenvironment-responsive
nZnO
Pf-encapsulated
micelles
holds
great
as
location-specific
dual-response
delivery
platform
curing
refractory,
Abstract
Even
though
radiotherapy
is
the
most
important
therapeutic
strategy
for
colon
cancer
treatment,
there
an
enormous
demand
to
improve
radiosensitivity
in
solid
tumor
destruction.
For
this
purpose,
a
biomimetic
nanoplatform
based
on
hollow
polydopamine
nanoparticles
(HP)
with
homologous
targeting
and
pH‐responsive
drug
release
properties
designed.
In
work,
HP
constructed
by
using
chelation
competition‐induced
polymerization
then
modified
cell
membrane.
Hollow
integrated
Pt
(Pt@HP)
has
catalase‐like
activity,
which
can
be
used
trigger
endogenous
H
2
O
into
,
relieving
hypoxia
of
microenvironment
(TME).
With
mesoporous
shells
large
cavities,
Pt@HP
shows
efficient
apoptin
100–109
(AP)
verteporfin
(VP)
loading
form
AVPt@HP@M.
Under
X‐ray
irradiation,
AVPt@HP@M
exerts
radiosensitization
effect
via
multiple
strategies,
including
(Pt
NPs),
enhancing
apoptosis
(AP),
X‐ray‐induced
photodynamic
therapy
(X‐PDT)
(VP).
Further
metabonomics
analysis
that
specific
mechanism
through
influencing
purine
metabolism.
Without
appreciable
systemic
toxicity,
highlights
new
effective
provides
reference
treating
malignant
tumors.
