Functional hemostatic hydrogels: design based on procoagulant principles DOI Creative Commons

Boxiang Zhang,

Min Wang,

Heng Tian

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(7), С. 1706 - 1729

Опубликована: Янв. 1, 2024

Uncontrolled hemorrhage results in various complications and is currently the leading cause of death general population.

Язык: Английский

Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties DOI Creative Commons
Ying Chen, Xing Wang,

Sheng Tao

и другие.

Military Medical Research, Год журнала: 2023, Номер 10(1)

Опубликована: Авг. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Язык: Английский

Процитировано

163

Recent advances in responsive hydrogels for diabetic wound healing DOI Creative Commons

Siming Zhang,

Gaoran Ge, Yi Qin

и другие.

Materials Today Bio, Год журнала: 2022, Номер 18, С. 100508 - 100508

Опубликована: Ноя. 30, 2022

Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.

Язык: Английский

Процитировано

138

Multifunctional Hydrogels for the Healing of Diabetic Wounds DOI
Tao Xiang,

Qianru Guo,

Lianghao Jia

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Язык: Английский

Процитировано

124

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds DOI
Yuan Xiong, Xiangyu Chu, Tao Yu

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Апрель 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Язык: Английский

Процитировано

100

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives DOI Creative Commons

Anthony Ko,

Caizhi Liao

BMEMat, Год журнала: 2023, Номер 1(3)

Опубликована: Июнь 30, 2023

Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.

Язык: Английский

Процитировано

68

Injectable sodium alginate hydrogel loaded with plant polyphenol-functionalized silver nanoparticles for bacteria-infected wound healing DOI
Qinsheng Hu, Yong Nie, Jun Xiang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 234, С. 123691 - 123691

Опубликована: Фев. 20, 2023

Язык: Английский

Процитировано

57

Repair of degenerative nucleus pulposus by polyphenol nanosphere-encapsulated hydrogel gene delivery system DOI
Yu Wang, Ye Wu, Bo Zhang

и другие.

Biomaterials, Год журнала: 2023, Номер 298, С. 122132 - 122132

Опубликована: Апрель 25, 2023

Язык: Английский

Процитировано

47

Stimuli‐Responsive Hydrogels for Antibacterial Applications DOI
Zhe Hao, Xiyan Li, Ruizhong Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Язык: Английский

Процитировано

31

Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications DOI Creative Commons
Md. Mahamudul Hasan Rumon, Md. Sohanur Rahman, Anwarul Azim Akib

и другие.

Discover Materials, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Язык: Английский

Процитировано

17

Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing DOI Creative Commons

Xuehao Tian,

Yuting Wen, Zhongxing Zhang

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

9