Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Май 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Янв. 15, 2023
Abstract
“Nanozymes”
usually
refers
to
inorganic
nanomaterials
with
enzyme‐like
catalytic
activities.
The
research
into
nanozymes
is
one
of
the
hot
topics
on
horizon
interdisciplinary
science
involving
materials,
chemistry,
and
biology.
Although
great
progress
has
been
made
in
design,
synthesis,
characterization,
application
nanozymes,
study
underlying
microscopic
mechanisms
kinetics
still
not
straightforward.
Density
functional
theory
(DFT)
calculations
compute
potential
energy
surfaces
along
reaction
coordinates
for
chemical
reactions,
which
can
give
atomistic‐level
insights
micro‐mechanisms
nanozymes.
Therefore,
DFT
have
playing
an
increasingly
important
role
exploring
past
years.
either
predict
details
processes
complement
experiments
or
further
develop
theoretical
models
depict
physicochemical
rules.
In
this
review,
corresponding
summarized.
Particularly,
review
focuses
computational
studies
that
closely
interplay
experiments.
relevant
experimental
results
without
will
be
also
briefly
discussed
offer
a
historic
overview
how
computations
promote
understanding
Advanced Materials,
Год журнала:
2023,
Номер
35(30)
Опубликована: Апрель 21, 2023
Bacterial
infection
is
one
of
the
greatest
challenges
to
public
health,
requiring
new
therapeutic
methods.
Herein,
an
innovative
nanozyme-armed
phage
(phage@palladium
(Pd))
system
fabricated
for
combating
bacterial
infection.
The
proposed
phage@Pd
preserves
function
phages
achieve
precise
recognition
and
adhesion
host
Escherichia
coli.
In
aid
phages,
ultrasmall
Pd
nanozymes
equipped
with
conspicuous
pH-dependent
peroxidase-like
activity
can
generate
toxic
hydroxyl
radical
around
bacteria
in
acidic
hydrogen-peroxide-overexpressed
microenvironment
while
remaining
inert
physiological
conditions,
thus
realizing
noteworthy
elimination
at
infected
sites,
meantime
ensuring
biological
safety
healthy
tissues.
addition,
filamentous
structure
also
enhance
its
bactericidal
efficiency
toward
nonhost
by
randomly
entangling
on
them,
indicating
possible
broad-spectrum
germicidal
efficacy.
Notably,
not
only
eradicate
planktonic
bacteria,
but
kill
inside
biofilm
vitro.
For
both
vivo
models
acute
pneumonia
or
subcutaneous
abscess,
shows
significant
eliminating
promoting
tissue
recovery.
These
results
demonstrate
that
nanohybrid
a
safe
effective
antimicrobial
agent,
providing
insight
into
development
advanced
antibacterial
materials.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(23), С. 12586 - 12600
Опубликована: Июнь 6, 2023
Nanozymes
have
shown
great
promise
in
reactive
oxygen
species
(ROS)-mediated
tumor
therapy
with
mitigated
side
effects
but
are
normally
limited
by
the
complex
microenvironment
(TME).
Herein,
to
overcome
adverse
of
TME,
such
as
hypoxia
and
high
endogenous
glutathione
(GSH),
an
aptamer-functionalized
Pd@MoO3–x
nano-hydrangea
(A-Pd@MoO3–x
NH)
is
constructed
for
high-efficiency
cancer
therapy.
Utilizing
irregular
shape
characteristics
nano
Pd,
A-Pd@MoO3–x
NH
nanozyme
simultaneously
exposes
catalase-like
Pd(111)
oxidase-like
Pd(100)
surface
facets
dual
active
centers.
This
can
catalyze
cascade
enzymatic
reactions
negative
caused
accumulation
cytotoxic
superoxide
(O2•–)
radicals
TME
without
any
external
stimuli.
In
addition,
effectively
degrade
overexpressed
(GSH)
through
redox
reaction
avoid
nontherapeutic
consumption
O2•–
radicals.
More
significantly,
a
reversible
electron
station,
MoO3–x
extract
electrons
from
H2O2
decomposing
on
or
GSH
degradation
transfer
them
back
bridges
few
Mo–Pd
bonds.
synergistically
enhance
enzyme-like
activities
centers
GSH-degrading
ability
enrich
this
way,
selectively
remarkably
kill
cells
while
keeping
normal
cell
line
unharmed.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Апрель 14, 2024
Although
nanozymes
have
drawn
great
attention
over
the
past
decade,
activities
of
peroxidase-like,
oxidase-like,
and
catalase-like
are
often
pH
dependent
with
elusive
mechanism,
which
largely
restricts
their
application.
Therefore,
a
systematical
discussion
on
pH-related
catalytic
mechanisms
together
methods
to
overcome
this
limitation
is
in
need.
In
review,
various
exhibiting
pH-dependent
collected
root
causes
for
dependence
comprehensively
analyzed.
Subsequently,
regulatory
concepts
including
environment
reconstruction
direct
activity
improvement
break
restriction
summarized.
Moreover,
applications
pH-independent
sensing,
disease
therapy,
pollutant
degradation
overviewed.
Finally,
current
challenges
future
opportunities
development
suggested.
It
anticipated
that
review
will
promote
further
design
broaden
application
range
higher
efficiency.
Advanced Materials,
Год журнала:
2023,
Номер
35(22)
Опубликована: Март 25, 2023
Reactive
oxygen
species
(ROS)-mediated
tumor
catalytic
therapy
is
typically
hindered
by
gap
junction
proteins
that
form
cell-to-cell
channels
to
remove
cytotoxic
ROS,
thereby
protecting
cells
from
oxidative
damage.
In
this
work,
a
multifunctional
nanozyme,
FePGOGA,
designed
and
prepared
Fe(III)-mediated
polymerization
(FeP),
followed
glucose
oxidase
(GOx)
GAP19
peptides
co-loading
through
electrostatic
π-π
interactions.
The
FePGOGA
nanozyme
exhibits
excellent
cascade
peroxidase-
glutathione-oxidase-like
activities
efficiently
catalyze
hydrogen
peroxide
conversion
hydroxyl
radicals
convert
reduced
glutathione
oxidized
disulfide.
loaded
GOx
starves
the
tumors
aggravates
stress
decomposition,
while
block
hemichannels
inducing
degradation
of
Cx43,
thus
increasing
accumulation
intracellular
decreasing
transport
glucose.
Furthermore,
ROS
reacts
with
primary
amines
heat
shock
destroy
their
structure
function,
enabling
photothermal
at
widely
sought-after
mild
temperature
(mildPTT,
≤45
°C).
vivo
experiments
demonstrate
significant
antitumor
effectof
on
cal27
xenograft
under
near-infrared
light
irradiation.
This
study
demonstrates
successful
ablation
overcome
resistance
ROS-mediated
therapy,
providing
regulator
suppress
self-preservation
during
starvation,
mildPTT.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
As
a
powerful
tool,
nanozyme
catalysts
broaden
the
avenues
to
implement
bio‐inspired
solutions
for
addressing
many
important
concerns,
covering
energy,
healthcare,
environment,
and
more.
Recent
endeavors,
characterized
by
atomic
precision,
have
enabled
extensive
exploration
of
single‐atom
nanozymes
(SAzymes)
with
high
catalytic
activity,
superior
substrate
selectivity,
integrated
multifunctionalities,
thus
becoming
an
emerging
field
that
bridges
nanotechnology
biology.
This
review
provides
brief
outline
progress
summarizes
latest
research
advances
regarding
SAzymes
in
biomedical
therapeutics,
mainly
including
tumor
therapy,
wound
antibacterial
tissue
anti‐inflammatory
focus
on
their
prototypical
synthesis
therapeutic
mechanisms.
Finally,
current
challenges
future
perspectives
engineering
advanced
are
also
discussed
outlooked.
It
is
anticipated
this
area
shall
provide
useful
guidance
therapy.