Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds DOI
Zhiyuan Hu,

Shan Jie,

Yuyu Cui

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)

Опубликована: Май 25, 2024

Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.

Язык: Английский

Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication DOI
Yun Sun, Bolong Xu, Xueting Pan

и другие.

Coordination Chemistry Reviews, Год журнала: 2022, Номер 475, С. 214896 - 214896

Опубликована: Окт. 27, 2022

Язык: Английский

Процитировано

152

Multifunctional mesoporous silica nanoparticles for biomedical applications DOI Creative Commons
Bolong Xu, Shanshan Li, Rui Shi

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Язык: Английский

Процитировано

138

Reaction Mechanisms and Kinetics of Nanozymes: Insights from Theory and Computation DOI
Xiaomei Shen, Zhenzhen Wang,

Xuejiao J. Gao

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Янв. 15, 2023

Abstract “Nanozymes” usually refers to inorganic nanomaterials with enzyme‐like catalytic activities. The research into nanozymes is one of the hot topics on horizon interdisciplinary science involving materials, chemistry, and biology. Although great progress has been made in design, synthesis, characterization, application nanozymes, study underlying microscopic mechanisms kinetics still not straightforward. Density functional theory (DFT) calculations compute potential energy surfaces along reaction coordinates for chemical reactions, which can give atomistic‐level insights micro‐mechanisms nanozymes. Therefore, DFT have playing an increasingly important role exploring past years. either predict details processes complement experiments or further develop theoretical models depict physicochemical rules. In this review, corresponding summarized. Particularly, review focuses computational studies that closely interplay experiments. relevant experimental results without will be also briefly discussed offer a historic overview how computations promote understanding

Язык: Английский

Процитировано

98

Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection DOI
Lulu Jin, Fangfang Cao, Yong Gao

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(30)

Опубликована: Апрель 21, 2023

Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phage@palladium (Pd)) system fabricated for combating bacterial infection. The proposed phage@Pd preserves function phages achieve precise recognition and adhesion host Escherichia coli. In aid phages, ultrasmall Pd nanozymes equipped with conspicuous pH-dependent peroxidase-like activity can generate toxic hydroxyl radical around bacteria in acidic hydrogen-peroxide-overexpressed microenvironment while remaining inert physiological conditions, thus realizing noteworthy elimination at infected sites, meantime ensuring biological safety healthy tissues. addition, filamentous structure also enhance its bactericidal efficiency toward nonhost by randomly entangling on them, indicating possible broad-spectrum germicidal efficacy. Notably, not only eradicate planktonic bacteria, but kill inside biofilm vitro. For both vivo models acute pneumonia or subcutaneous abscess, shows significant eliminating promoting tissue recovery. These results demonstrate that nanohybrid a safe effective antimicrobial agent, providing insight into development advanced antibacterial materials.

Язык: Английский

Процитировано

87

Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes DOI Creative Commons
Lu Yang, Shuming Dong, Shili Gai

и другие.

Nano-Micro Letters, Год журнала: 2023, Номер 16(1)

Опубликована: Ноя. 21, 2023

Since the discovery of enzyme-like activity Fe

Язык: Английский

Процитировано

74

Dual Active Centers Linked by a Reversible Electron Station as a Multifunctional Nanozyme to Induce Synergetically Enhanced Cascade Catalysis for Tumor-Specific Therapy DOI

Qi Zhao,

Lirong Zheng, Yixuan Gao

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(23), С. 12586 - 12600

Опубликована: Июнь 6, 2023

Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor therapy with mitigated side effects but are normally limited by the complex microenvironment (TME). Herein, to overcome adverse of TME, such as hypoxia and high endogenous glutathione (GSH), an aptamer-functionalized Pd@MoO3–x nano-hydrangea (A-Pd@MoO3–x NH) is constructed for high-efficiency cancer therapy. Utilizing irregular shape characteristics nano Pd, A-Pd@MoO3–x NH nanozyme simultaneously exposes catalase-like Pd(111) oxidase-like Pd(100) surface facets dual active centers. This can catalyze cascade enzymatic reactions negative caused accumulation cytotoxic superoxide (O2•–) radicals TME without any external stimuli. In addition, effectively degrade overexpressed (GSH) through redox reaction avoid nontherapeutic consumption O2•– radicals. More significantly, a reversible electron station, MoO3–x extract electrons from H2O2 decomposing on or GSH degradation transfer them back bridges few Mo–Pd bonds. synergistically enhance enzyme-like activities centers GSH-degrading ability enrich this way, selectively remarkably kill cells while keeping normal cell line unharmed.

Язык: Английский

Процитировано

69

Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications DOI
Kaizheng Feng, Guancheng Wang, Shi Wang

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Апрель 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Язык: Английский

Процитировано

68

Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy DOI

Yongjuan Li,

Yu Zhang,

Ya Dong

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(22)

Опубликована: Март 25, 2023

Reactive oxygen species (ROS)-mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell-to-cell channels to remove cytotoxic ROS, thereby protecting cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, designed and prepared Fe(III)-mediated polymerization (FeP), followed glucose oxidase (GOx) GAP19 peptides co-loading through electrostatic π-π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase- glutathione-oxidase-like activities efficiently catalyze hydrogen peroxide conversion hydroxyl radicals convert reduced glutathione oxidized disulfide. loaded GOx starves the tumors aggravates stress decomposition, while block hemichannels inducing degradation of Cx43, thus increasing accumulation intracellular decreasing transport glucose. Furthermore, ROS reacts with primary amines heat shock destroy their structure function, enabling photothermal at widely sought-after mild temperature (mildPTT, ≤45 °C). vivo experiments demonstrate significant antitumor effectof on cal27 xenograft under near-infrared light irradiation. This study demonstrates successful ablation overcome resistance ROS-mediated therapy, providing regulator suppress self-preservation during starvation, mildPTT.

Язык: Английский

Процитировано

65

Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges DOI

Weiyi He,

Jiahao Wu, Jianli Liu

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(16)

Опубликована: Янв. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Язык: Английский

Процитировано

63

Research progress of nanozymes in colorimetric biosensing: Classification, activity and application DOI

Luyu Yang,

Xiaoyun Xu, Yang Song

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612

Опубликована: Март 21, 2024

Язык: Английский

Процитировано

63