Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Год журнала: 2022, Номер 34(2), С. 107518 - 107518

Опубликована: Май 14, 2022

Язык: Английский

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Язык: Английский

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Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(7), С. 4279 - 4293

Опубликована: Фев. 6, 2023

How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic microenvironments increase O2 production. Excitingly, maximized CAT-like efficiency is 138-fold higher than that typical MnO2 and exhibits 14.3-fold affinity natural catalase, demonstrated by steady-state kinetics. We verify well-defined l-Cys-Cu···O active sites match through l-Cys bridge-accelerated electron transfer from Cys-Cu disclosed density functional theory calculations. Simultaneously, high loading atoms also enable generation •OH via Fenton-like reaction. Moreover, under X-ray irradiation, converts 1O2 for cascading radiodynamic therapy, thereby facilitating multiple reactive oxygen species (ROS) radiosensitization achieve substantial antitumor.

Язык: Английский

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Nanozyme Catalytic Turnover and Self-Limited Reactions

ACS Nano, Год журнала: 2021, Номер 15(10), С. 15645 - 15655

Опубликована: Окт. 8, 2021

Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.

Язык: Английский

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Exploration of nanozymes in viral diagnosis and therapy

Exploration, Год журнала: 2022, Номер 2(1)

Опубликована: Янв. 25, 2022

Abstract Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, synthesis of nanozymes their mechanisms advanced beyond simple replacement allowing fascinating applications in various fields such as biosensing disease treatment. particular, exploration powerful toolkits diagnostic viral testing antiviral therapy has attracted growing attention. It can address great challenges faced by current enzyme‐based technologies, high cost storage difficulties. Therefore, nanozyme provide a novel nanozyme‐based therapeutic regime broader availability generalizability that keys fighting pandemic COVID‐19. Herein, we timely review state‐of‐the‐art regarding activities, well focused discussion on recent research into use therapy. The remaining future perspectives will also be outlined. Ultimately, this inform readers knowledge inspire more innovative studies push forward frontier field.

Язык: Английский

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Enzyme-mimicking capacities of carbon-dots nanozymes: Properties, catalytic mechanism, and applications – A review

International Journal of Biological Macromolecules, Год журнала: 2021, Номер 194, С. 676 - 687

Опубликована: Ноя. 20, 2021

Язык: Английский

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Multi-enzyme activity nanozymes for biosensing and disease treatment

Coordination Chemistry Reviews, Год журнала: 2022, Номер 473, С. 214784 - 214784

Опубликована: Сен. 13, 2022

Язык: Английский

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Photo-enhanced upcycling H2O2 into hydroxyl radicals by IR780-embedded Fe3O4@MIL-100 for intense nanocatalytic tumor therapy

Biomaterials, Год журнала: 2022, Номер 287, С. 121687 - 121687

Опубликована: Июль 19, 2022

Язык: Английский

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Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Год журнала: 2023, Номер 16(1)

Опубликована: Ноя. 21, 2023

Since the discovery of enzyme-like activity Fe

Язык: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612

Опубликована: Март 21, 2024

Язык: Английский

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