Pathology - Research and Practice, Год журнала: 2024, Номер 258, С. 155337 - 155337
Опубликована: Май 3, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
17
Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11
Опубликована: Сен. 17, 2024
The discovery of novel and innovative therapeutic strategies for cancer treatment management remains a major global challenge. Exosomes are endogenous nanoscale extracellular vesicles that have garnered increasing attention as vehicles advanced drug delivery targeted therapy. attractive physicochemical biological properties exosomes, including increased permeability, biocompatibility, extended half-life in circulation, reduced toxicity immunogenicity, multiple functionalization strategies, made them preferred other diseases. Small interfering RNAs (siRNAs) remarkably able to target any known gene: an attribute harnessed knock down cancer-associated genes viable strategy management. Extensive research on exosome-mediated siRNAs targeting diverse types has yielded promising results anticancer therapy, with some formulations progressing through clinical trials. This review catalogs recent advances siRNA several cancer, the manifold benefits minimal drawbacks such systems. Additionally, we highlighted potential plant-derived exosomes systems treatment, offering numerous advantages scalability, compared traditional methods. These their unique characteristics effective delivery, represent significant advancement nanomedicine therapeutics. Further exploration manufacturing processes mechanisms could significantly advance natural medicine enhance efficacy exosome-based therapies.
Язык: Английский
Процитировано
8
Onco, Год журнала: 2025, Номер 5(1), С. 2 - 2
Опубликована: Янв. 2, 2025
The integration of small interfering RNA (siRNA) with traditional cancer therapies represents a promising frontier in oncology aimed at enhancing treatment effectiveness, reducing side effects, and overcoming drug resistance. This review highlights the potential siRNA to selectively silence genes that are overexpressed or uniquely expressed cells, thereby disrupting critical pathways support tumor growth survival. Key target discussed include survivin, VEGF, EGFR, c-MET, HER2, MUC1, Bcl-2, all which play vital roles proliferation, angiogenesis, resistance therapies. Clinical trials investigating various candidates, such as EZN-3042 ALN-VSP, indicate these generally well-tolerated; however, significant challenges persist, including effective delivery stability siRNA. Recent advancements nanoparticle-based systems have shown promise addressing issues. Future research will focus on optimizing methods, personalizing based individual genetic profiles, establishing clearer regulatory guidelines for approval. As field evolves, siRNA-based combination poised become an integral part precision oncology, offering new therapeutic options hope patients difficult-to-treat cancers.
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123581 - 123581
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163227 - 163227
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Medicine in Drug Discovery, Год журнала: 2023, Номер 21, С. 100173 - 100173
Опубликована: Ноя. 29, 2023
Colorectal cancer (CRC), ranking as the third most common globally, is associated with a high death rate. The colon, also known large intestine, site where colorectal initially develops. It lengthy tube that facilitates passage of digested food to rectum and ultimately out body. CRC has potential affect other organs or regions body if not diagnosed treated earlier. Delivering precise medications in site-specific target-oriented manner can improve chronic disease therapy various ways. In recent years, there have been number innovations nanomedicine (including chemotherapeutic medicines, biological agents, immunotherapeutic such applications) for treatment diseases, including CRC. current review provides an up-to-date overview latest advancements field nanomedicines nano-based drug delivery systems treatment. An in-depth investigation conducted into study nanomaterials liposomes, metal, polymeric peptides nanomaterials, exploring their applications enhancing efficacy both new existing drugs. This focuses on opportunities challenges posed by delivering drugs derived from natural synthetic sources. Additionally, information future prospects provided.
Язык: Английский
Процитировано
12
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131048 - 131048
Опубликована: Март 23, 2024
Язык: Английский
Процитировано
4
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Май 28, 2024
Abstract Ribonucleic acid (RNA) therapeutics offer a broad prospect in cancer treatment. However, their successful application requires overcoming various physiological barriers to effectively deliver RNAs the target sites. Currently, number of RNA delivery systems based on polymeric nanoparticles are developed overcome these delivery. This work provides an overview existing for gene therapy, and particularly summarizes those that entering clinical phase. then discusses core features latest research developments tumor microenvironment‐responsive polymer‐based carriers which designed pathological characteristics microenvironment. Finally, this also proposes opportunities transformation therapies into immunotherapy methods applications.
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1029 - 1029
Опубликована: Авг. 1, 2024
In recent decades, the pursuit of drug delivery systems has led to development numerous synthetic options aimed at enhancing efficacy while minimizing side effects. However, practical application these is often hindered by challenges such as inefficiency, cytotoxicity, and immunogenicity. Extracellular vesicles, natural carriers for drugs, emerge promising alternatives with distinct advantages over carriers. Notably, EVs exhibit biocompatibility, low immunogenicity, inherent tissue-targeting capabilities, thus opening new avenues strategies. This review provides an overview EVs, including their biogenesis absorption mechanisms. Additionally, we explore current research efforts focusing on harnessing potential carriers, encompassing aspects purification techniques, loading, bioengineering targeted delivery. Finally, discuss existing future prospects therapeutic agents in clinical settings. comprehensive analysis aims shed light versatile effective tools delivery, particularly realm cancer therapy.
Язык: Английский
Процитировано
4
Nature Reviews Urology, Год журнала: 2024, Номер unknown
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
3