Background
and
purpose:
Cell
biology
approaches
have
gained
a
successful
integration,
development
application
of
nanotechnology
with
stem
cell
engineering
led
to
the
emergence
new
interdisciplinary
field
known
as
(SCN).
Recent
studies
showed
potential
advancement
developments
for
SCN
applications
in
drug
delivery
systems.
Cancer,
neurodegenerative,
muscle
blood
diseases,
gene
therapies,
tissue
regenerative
medicine
are
important
targets
SCN.
Experimental
approach:
In
this
overview,
we
searched
literature
using
common
online
websites
research
read
open
access,
full-text
available
articles
since
2013.
Key
results:
The
vary
according
type
disease
they
targeted
strategies
proposed,
whether
diagnostic
or
therapeutic.
addition
use
cells,
utilisation
their
membranes,
secretomes,
exosomes
extracellular
vesicles
an
appropriate
strategy
is
also
aspect
research.
Conclusion:
This
brief
overview
over
last
ten
years
aims
provide
insight
into
frontiers
nanotechnology-mediated
Next Materials,
Год журнала:
2024,
Номер
2, С. 100128 - 100128
Опубликована: Янв. 1, 2024
This
article
is
an
overview
of
the
current
state
nanoparticles
because
their
emerging
usage
in
cancer
treatment,
covering
that
have
been
authorized
for
use
therapy
currently
undergoing
clinical
testing.
Recent
advances
nanoparticle
engineering,
coupled
with
enhanced
understanding
critical
attributes
(size,
shape,
and
surface
properties)
conjunction
biological
systems,
present
novel
prospects
therapeutic
development.
Although
inorganic
metallic
are
gaining
recognition
studies
due
to
potential
usefulness
but
nanomaterials
primarily
polymeric,
liposomal,
nano
crystal
based
dominate
therapy.
Polymeric
(NPs)
contain
specific
ligands,
such
as
polyglycolic
acid
(PGA)
polylactic
(PLA),
which
a
chemical
affinity
malignant
cells
target
tumors.
Nanocrystals
stand
out
high
loading
efficiency,
stability,
extended
drug
release,
capacity
deliver
poorly
soluble
medications.
The
limitations
conventional
chemotherapy
overcome
variety
applications
improved
care
by
metal-based
nanoparticles,
either
used
alone
or
combination.
dynamic
nature
nanotechnology
drives
continued
developments
like
protein-based
micelles.
Polymer
lipid
encapsulation
within
nanocrystals
becoming
more
popular,
suggesting
long-term
trend.
advancement
marks
significant
breakthrough
life-saving
nanotechnology,
particularly
sets
stage
pioneering
nanomedicine.
BioChem,
Год журнала:
2024,
Номер
4(1), С. 38 - 61
Опубликована: Март 13, 2024
Arthritis,
a
global
health
burden
comprising
osteoarthritis
and
rheumatoid
arthritis,
demands
advanced
therapeutic
approaches.
In
this
context,
flavonoids,
diverse
group
of
naturally
occurring
compounds
abundant
in
fruits,
vegetables,
medicinal
plants,
have
emerged
as
promising
candidates
for
mitigating
the
inflammatory
processes
associated
with
arthritic
conditions.
This
review
aims,
first,
to
provide
comprehensive
exploration
potential
focusing
on
specific
such
quercetin,
epigallocatechin-3-gallate
(EGCG),
apigenin,
luteolin,
fisetin,
silibinin,
kaempferol,
naringenin,
myricetin.
The
second
section
delves
into
anti-arthritic
activities
these
drawing
insights
from
clinical
trials
scientific
studies.
Each
flavonoid
is
scrutinized
individually
elucidate
its
mechanisms
action
efficacy
context
both
arthritis.
third
highlights
challenges
harnessing
flavonoids
anti-inflammatory
purposes.
Bioavailability
limitations
pose
significant
hurdle,
prompting
innovative
strategies
use
nanoparticles
delivery
vehicles.
response
challenges,
fourth
focuses
emerging
field
flavonoid-based
nanoparticles.
includes
detailed
discussions
EGCG,
naringenin-based
nanoparticles,
highlighting
formulation
preclinical
evidence
supporting
their
arthritis
management.
targeted
sites
synergistic
combinations
other
are
also
discussed
avenues
enhance
impact
flavonoids.
consolidates
current
knowledge
nanoformulations
interventions
By
addressing
presenting
future
research
directions,
aims
contribute
advancement
effective
alleviating
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 21, 2024
Nanoparticles
are
attractive
therapeutic
tools
due
to
their
distinctive
characteristics,
including
more
accurate
drug
delivery,
improved
bioavailability,
and
enhanced
targeted
therapy.
This
review
offers
a
comprehensive
analysis
of
the
potentials
cutting-edge
nanoparticles
as
demonstrated
in
human
clinical
trials,
based
on
empirical
evidence.
Through
systematic
searches
major
scientific
databases,
relevant
studies
published
up
March
2024
were
included,
focusing
trials
utilizing
advanced
for
purposes.
The
discusses
diverse
applications
oncology,
infectious
diseases,
neurology,
other
medical
fields.
Additionally,
it
scrutinizes
safety
profiles,
efficacy
outcomes,
challenges
associated
with
nanoparticle-based
therapies.
findings
underscore
significant
progress
translating
nanoparticle
research
into
practice
highlight
potential
these
innovative
platforms
revolutionize
treatments.
contributes
valuable
insights
growing
field
therapeutics,
fostering
deeper
understanding
implications
practice.
Cell Proliferation,
Год журнала:
2024,
Номер
57(6)
Опубликована: Янв. 16, 2024
Abstract
Breast
cancer
has
overtaken
lung
as
the
number
one
worldwide.
Paclitaxel
(PTX)
is
a
widely
used
first‐line
anti‐cancer
drug,
but
it
not
very
effective
in
clinical
breast
therapy.
It
been
reported
that
triptolide
(TPL)
can
enhance
anticancer
effect
of
paclitaxel,
and
better
synergistic
therapeutic
effects
are
seen
with
concomitant
administration
PTX
TPL.
In
this
study,
we
developed
pH‐responsive
polymeric
micelles
for
co‐delivery
TPL,
which
disassembling
acidic
tumour
microenvironments
to
target
drug
release
effectively
kill
cells.
Firstly,
synthesized
amphiphilic
copolymer
mPEG
2000
‐PBAE
through
Michael
addition
reaction,
confirmed
by
various
characterizations.
Polymer
loaded
TPL
(TPL/PTX‐PMs)
were
prepared
thin
film
dispersion
method.
The
average
particle
size
TPL/PTX‐PMs
was
97.29
±
1.63
nm,
PDI
0.237
0.003
Zeta
potential
9.57
0.80
mV,
LC%
6.19
0.21%,
EE%
88.67
3.06%.
Carrier
material
biocompatibility
micelle
cytotoxicity
assessed
using
CCK‐8
method,
demonstrating
excellent
biocompatibility.
Under
same
concentration,
most
toxic
cells
had
strongest
proliferation
inhibitory
effect.
Cellular
uptake
assays
revealed
significantly
increased
intracellular
concentration
enhanced
antitumor
activity.
Overall,
micellar
promising
approach
Abstract
Phytonanoparticles
have
emerged
as
a
promising
class
of
biomaterials
for
enhancing
bone
regeneration
and
osseointegration,
offering
unique
advantages
in
biocompatibility,
multifunctionality,
sustainability.
This
comprehensive
review
explores
the
synthesis,
characterization,
applications
phytonanoparticles
tissue
engineering.
The
green
synthesis
approach,
utilizing
plant
extracts
reducing
stabilizing
agents,
yields
nanoparticles
with
intrinsic
bioactive
properties
that
can
synergistically
promote
osteogenesis.
We
examine
mechanisms
by
which
phytonanoparticles,
particularly
those
derived
from
gold,
silver,
zinc
oxide,
influence
key
molecular
pathways
osteogenesis,
including
RUNX2
Osterix
signaling.
discusses
advanced
strategies
phyto-nanoparticle
design,
such
surface
functionalization
stimuli-responsive
release
mechanisms,
enhance
their
efficacy
applications.
Preclinical
studies
demonstrating
improved
osteoblast
proliferation,
differentiation,
mineralization
are
critically
analyzed,
along
emerging
clinical
data.
Despite
results,
scalability,
standardization,
regulatory
approval
challenges
persist.
also
addresses
economic
environmental
implications
production.
Looking
ahead,
we
identify
research
directions,
developing
personalized
therapies,
combination
approaches
stem
cells
or
gene
delivery,
long-term
safety
assessments.
By
harnessing
power
plant-derived
nanomaterials,
represent
an
innovative
approach
to
addressing
complex
regeneration,
potential
spanning
dental,
orthopedic,
maxillofacial
surgery.
Graphical
abstract
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 20, 2025
Nanotechnology
has
become
a
groundbreaking
innovation
force
in
cancer
therapy,
offering
innovative
solutions
to
the
limitations
of
conventional
treatments
such
as
chemotherapy
and
radiation.
By
manipulating
materials
at
nanoscale,
researchers
have
developed
nanocarriers
capable
targeted
drug
delivery,
improving
therapeutic
efficacy
while
reducing
systemic
toxicity.
Nanoparticles
like
liposomes,
dendrimers,
polymeric
nanomaterials
shown
significant
promise
delivering
chemotherapeutic
agents
directly
tumor
sites,
enhancing
bioavailability
minimizing
damage
healthy
tissues.
In
addition
with
utilization
tools
quantum
dots
nanosensors
that
enables
more
precise
identification
biomarkers,
nanotechnology
is
also
playing
pivotal
role
early
detection
diagnosis.
Furthermore,
nanotechnology-based
strategies,
including
photothermal
gene
therapy
immunotherapy
are
novel
ways
combat
by
selectively
targeting
cells
immune
response.
Nevertheless,
despite
these
progressions,
obstacles
still
persist,
particularly
clinical
translation
technologies.
Issues
nanoparticle
toxicity,
biocompatibility,
complexity
regulatory
approval
hinder
widespread
adoption
nanomedicine
oncology.
This
review
discusses
different
applications
highlighting
its
potential
hurdles
implementation.
Future
research
needs
concentrate
on
addressing
unlock
full
providing
personalized,
effective,
minimally
invasive
treatments.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 17, 2023
Triple
positive
breast
cancer
(TPBC)
is
one
of
the
most
aggressive
cancer.
Due
to
unique
cell
phenotype,
aggressiveness,
metastatic
potential
and
lack
receptors
or
targets,
chemotherapy
choice
treatment
for
TNBC.
Doxorubicin
(DOX),
representative
agents
anthracycline
chemotherapy,
has
better
efficacy
in
patients
with
TNBC
(mTNBC).
DOX
anthracycline-based
regimens
have
higher
response
rates.
Nano-drug
delivery
systems
possess
targeting
ability
co-load,
deliver
release
chemotherapeutic
drugs,
active
gene
fragments
immune
enhancing
factors
effectively
inhibit
kill
tumor
cells.
Therefore,
advances
nano-drug
therapy
attracted
a
considerable
amount
attention
from
researchers.
In
this
article,
we
reviewed
progress
(e.g.,
Nanoparticles,
Liposomes,
Micelles,
Nanogels,
Dendrimers,
Exosomes,
etc.)
applied
We
also
summarize
current
clinical
trials
combined
checkpoint
inhibitors
(ICIS)
The
merits,
demerits
future
development
nanomedicine
are
envisioned,
aim
providing
new
class
safe
efficient
thoughts
Heliyon,
Год журнала:
2024,
Номер
10(9), С. e29726 - e29726
Опубликована: Апрель 16, 2024
Hybrid
nanostructures
exhibit
a
synergistic
combination
of
features
derived
from
their
individual
components,
showcasing
novel
characteristics
resulting
distinctive
structure
and
chemical/physical
properties.
Surface
modifiers
play
pivotal
role
in
shaping
INPs'
primary
attributes,
influencing
physicochemical
properties,
stability,
functional
applications.
Among
these
modifiers,
dendrimers
have
gained
attention
as
highly
effective
multifunctional
agents
for
INPs,
owing
to
unique
structural
qualities,
dendritic
effects,
Dendrimers
can
be
seamlessly
integrated
with
diverse
inorganic
nanostructures,
including
metal
NPs,
carbon
silica
QDs.
Two
viable
approaches
achieving
this
integration
involve
either
growing
or
grafting
dendrimers,
nanostructure-cored
dendrimers.
The
initial
step
involves
functionalizing
the
nanostructures'
surface,
followed
by
generation
through
stepwise
growth
attachment
pre-synthesized
dendrimer
branches.
This
hybridization
imparts
superior
qualities
structure,
biocompatibility,
solubility,
high
cargo
loading
capacity,
substantial
functionalization
potential.
Combining
properties
those
nanostructure
cores
creates
system
suitable
applications
such
theranostics,
bio-sensing,
component
isolation,
chemotherapy,
cargo-carrying
review
summarizes
recent
developments,
specific
focus
on
last
five
years,
within
realm
It
delves
into
INPs
explores
potential
INP-cored
biomedical
