Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Авг. 28, 2023
Depression
and
anxiety
are
the
most
common
mental
illnesses
affecting
children
adolescents,
significantly
harming
their
well-being.
Research
has
shown
that
regular
physical
activity
can
promote
cognitive,
emotional,
fundamental
movement
skills,
motor
coordination,
as
a
preventative
measure
for
depression
while
reducing
suicide
rate.
However,
little
is
known
about
potential
role
of
in
adolescent
anxiety.
The
studies
reviewed
this
paper
suggest
exercise
be
an
effective
adjunctive
treatment
to
improve
depressive
symptoms
although
research
on
its
neurobiological
effects
remains
limited.
Translational Psychiatry,
Год журнала:
2023,
Номер
13(1)
Опубликована: Янв. 19, 2023
Abstract
Aerobic
exercise
effectively
relieves
anxiety
disorders
via
modulating
neurogenesis
and
neural
activity.
The
molecular
mechanism
of
exercise-mediated
anxiolysis,
however,
remains
incomplete.
On
a
chronic
restrain
stress
(CRS)
model
in
adolescent
mice,
we
showed
that
14-day
treadmill
profoundly
maintained
normal
activity
axonal
myelination
the
medial
prefrontal
cortex
(mPFC),
association
with
prevention
anxiety-like
behaviors.
Further
interrogation
mechanisms
revealed
activation
mechanistic
target
rapamycin
(mTOR)
pathway
within
mPFC
under
training.
At
upstream
mTOR,
brain
RNA
methylation
inhibited
expression
Fragile
X
mental
retardation
protein
(FMRP)
to
activate
mTOR
pathway.
In
summary,
modulates
an
FMRP–mTOR
maintain
cortical
myelination,
contributing
improved
resilience.
These
results
extended
our
understanding
substrate
anxiolytic
effect
during
period.
Social
anxiety
symptoms
are
common
and
harmful
psychological
illness
in
college
students.
Although
some
studies
have
illustrated
that
physical
activity
could
reduce
social
symptoms,
the
specific
mechanism
is
still
unclear.
Based
on
theoretical
resilience
sleep,
this
study
constructed
a
serial
mediation
model
to
explore
whether
they
mediate
between
among
This
surveyed
9,530
students
from
three
colleges
China
mediating
effect
of
sleep
problems
symptoms.
Participants
were
investigated
with
International
Physical
Activity
Questionnaire,
Connor-Davidson
Resilience
Scale,
Sleep-related
problems,
Interaction
Anxiety
Scale
Phobia
Scale.
Correlations
variables
analysed
using
Pearson
correlation
analysis
analyses
performed
SPSS
PROCESS
macro
3.3
software.
The
found
was
negatively
associated
but
positively
resilience.
After
controlling
for
sociodemographic
variables,
can
not
only
indirectly
alleviate
through
separate
also
problems.
These
results
suggest
improving
levels
scores
by
increasing
quality.
great
reference
significance
prevention
intervention
students'
mental
health.
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Апрель 25, 2024
Alzheimer’s
disease
(AD)
is
a
complex
neurodegenerative
disorder
and
the
most
common
form
of
dementia.
There
are
two
main
types
AD:
familial
sporadic.
Familial
AD
linked
to
mutations
in
amyloid
precursor
protein
(APP),
presenilin-1
(PSEN1),
presenilin-2
(PSEN2).
On
other
hand,
sporadic
more
has
genetic,
epigenetic,
environmental
components
that
influence
onset
progression.
Investigating
epigenetic
mechanisms
associated
with
essential
for
increasing
understanding
pathology
identifying
biomarkers
diagnosis
treatment.
Chemical
covalent
modifications
on
DNA
RNA
can
epigenetically
regulate
gene
expression
at
transcriptional
post-transcriptional
levels
play
protective
or
pathological
roles
diseases.
Communications Biology,
Год журнала:
2023,
Номер
6(1)
Опубликована: Июнь 9, 2023
Aerobic
exercise
effectively
ameliorates
mental
disorders
including
anxiety
and
depression.
Current
findings
mainly
attribute
its
neural
mechanism
to
the
improvement
of
adult
neurogenesis,
while
leaving
possible
circuitry
unclear.
In
current
study,
we
identify
overexcitation
medial
prefrontal
cortex
(mPFC)
basolateral
amygdala
(BLA)
pathway
under
chronic
restraint
stress
(CRS),
14-day
treadmill
selectively
reverses
such
abnormalities.
Using
chemogenetic
approaches,
find
that
mPFC-BLA
circuit
is
necessary
for
preventing
anxiety-like
behaviors
in
CRS
mice.
These
results
collectively
suggest
a
by
which
training
improves
resilience
against
environmental
stress.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13897 - 13897
Опубликована: Сен. 9, 2023
Epigenetic
methylation
has
been
shown
to
play
an
important
role
in
transcriptional
regulation
and
disease
pathogenesis.
Recent
advancements
detection
techniques
have
identified
DNA
N6-methyldeoxyadenosine
(6mA)
RNA
N6-methyladenosine
(m6A)
as
modifications
at
the
sixth
position
of
adenine
RNA,
respectively.
While
distributions
functions
6mA
m6A
extensively
studied
prokaryotes,
their
roles
mammalian
brain,
where
they
are
enriched,
still
not
fully
understood.
In
this
review,
we
provide
a
comprehensive
summary
current
research
progress
on
m6A,
well
associated
writers,
erasers,
readers
both
levels.
Specifically,
focus
potential
fundamental
biological
pathways
genome
highlight
significant
regulatory
neurodegenerative
diseases.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
Physical
exercise
has
beneficial
effect
on
anxiety
disorders,
but
the
underlying
molecular
mechanism
remains
largely
unknown.
Here,
it
is
demonstrated
that
physical
can
downregulate
S-nitrosylation
of
gephyrin
(SNO-gephyrin)
in
basolateral
amygdala
(BLA)
to
exert
anxiolytic
effects.
It
found
level
SNO-gephyrin
significantly
increased
BLA
high-anxiety
rats
and
a
downregulation
at
cysteines
212
284
produced
effect.
Mechanistically,
inhibition
by
either
Cys212
or
Cys284
mutations
surface
expression
GABA
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
In
recent
years,
high-intensity
interval
training
(HIIT)
has
gained
significant
attention
due
to
its
efficient
use
of
time.
Studies
have
shown
that
engaging
in
regular
physical
activity
can
effectively
reduce
symptoms
anxiety.
Given
the
potential
side
effects
and
limitations
associated
with
pharmacological
treatments
for
anxiety
disorders,
there
is
a
growing
interest
exploring
non-pharmacological
interventions.
HIIT,
as
an
alternative
approach,
offers
promising
avenue
managing
without
relying
on
medication.
However,
specific
efficacy
applicability
HIIT
individuals
diagnosed
disorders
not
been
systematically
summarized
literature.
This
scoping
review
aims
explore
effectiveness
intervention
improving
symptoms,
well
range
applicability,
by
synthesizing
existing
research.
A
methodology
was
employed
search
databases
including
PubMed,
Web
Science,
EMbase,
Cochrane
Library.
were
selected
based
predefined
criteria:
randomized
controlled
trials
(RCTs),
cohort
studies,
quasi-experimental
designs
focusing
improvement
anxiety,
using
primary
intervention.
Exclusion
criteria
included
studies
mixed
interventions
or
populations
comorbid
conditions.
Two
independent
evaluators
screened
titles,
abstracts,
full
texts,
extracted
data
pre-tested
form,
resolved
discrepancies
through
discussion
ensure
consistency
accuracy.
total
541
articles
identified,
which
16
met
inclusion
this
review.
The
samples
comprised
various
populations,
healthy
subjects,
overweight
males,
prostate
cancer
patients,
etc.
Twelve
indicated
significantly
improves
especially
lower
baseline
effect
less
pronounced
those
higher
Additionally,
suggest
variations
protocols-such
frequency,
intensity,
duration-may
influence
extent
symptoms.
study
underscores
High-Intensity
Interval
Training
effective
reducing
when
tailored
individual
characteristics.
Variations
parameters
such
duration
are
critical
factors
optimizing
HIIT's
mental
health
benefits.HIIT
shows
promise
valuable
tool
improve
outcomes
implemented
careful
consideration
differences
protocol
variations.
provides
foundation
refining
protocols
expanding
their
across
diverse
populations.
Brain Research Bulletin,
Год журнала:
2025,
Номер
223, С. 111280 - 111280
Опубликована: Фев. 25, 2025
The
impairment
of
cognitive
function
has
been
associated
with
Alzheimer's
disease
(AD).
Exercise
exerts
a
positive
modulatory
effect
on
cognition
by
reducing
synapse
injury.
However,
limited
in
vivo
evidence
is
available
to
validate
the
neuroprotective
TREM2
synaptic
this
phenomenon.
Here,
we
aim
explore
whether
physical
exercise
pretreatment
alters
Aβ-induced
recognition
memory
structural
plasticity
within
hippocampus
AD
rats.
METHODS：:
In
study
1,
fifty-two
Sprague-Dawley
(SD)
rats
were
randomly
divided
into
following
four
groups:
control
group
(C
group,
n
=
13),
(AD
4
weeks
and
(Exe+AD
blank
(Exercise
13).
Four
treadmill
intervention
was
performed,
model
established
intra-cerebroventricular
injection
(ICV)
Aβ1-42
protein.
After
3
weeks,
also
conducted
novel
object
test
evaluate
behavior
assessment.
Golgi
staining
transmission
electron
microscopy
used
morphology
ultrastructure
neurons.
Western
blotting
measure
expression
hippocampal
proteins.
Extracellular
neurotransmitters
detected
microdialysis
coupled
high-performance
liquid
chromatography.
2,
33
SD
three
11),
AAV-Control
(AAV-Control+Exe+AD
AAV-TREM2
(AAV-TREM2
+Exe+AD
11).
Stereotactic
intracerebral
bilateral
performed
achieve
microglial
down-expression
using
adeno-associated
virus
(AAV)
CD68
promoter.
Aβ
injection,
all
received
molecular
experiment,
which
same
experiment
2.
Novel
index
significantly
decreased,
western
blot
demonstrate
that
protein
decreased
(P
<
0.001).
But
reversed
phenomenon(P
addition,
compared
Con
neuron
from
Exe+AD
exhibited
more
complex
branching
pattern
0.05).
And
impaired
observed
group.
Hippocampal
synaptic-related
(SYX,
SYP,
GAP43,
PSD95)
neurotransmitter
(DA,
Glu,
GABA)
0.01)
neuroprotection
can
be
found
are
inhibition
injury
activate
when
blockade
reduced
brain
protective
rat
model,
including
increased
damage
neuronal
dendritic
complexity,
ultrastructure,
decrease
synapses-related
protein,
typical
neurotransmitter.
Treadmill
facilitated
acquisition
via
TREM2-mediated
an
model.
