Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment DOI Creative Commons
Yixin Bian,

Xuejie Cai,

Zehui Lv

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Language: Английский

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks DOI
Yue Li, Yong Miao, Lunan Yang

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Language: Английский

Citations

169
Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing DOI Creative Commons

Rongxin Yu,

Hongping Chen, Jian He

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Language: Английский

Citations

69
Dually Crosslinked Copper‐Poly(tannic acid) Nanoparticles with Microenvironment‐Responsiveness for Infected Wound Treatment DOI
Dongying Li, Jiarun Li, Siwei Wang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(17)

Published: Feb. 26, 2023

Abstract Reducing the burden of death due to wound infection is an urgent global public health priority. Metal‐phenolic networks (MPNs) have received widespread attention in antimicrobial infections their facile synthesis process, excellent biocompatibility, and properties brought about by polyphenols metal ions. However, typical therapeutic MPNs show rapid release ions poor solution stability, impeding long‐acting efficacy multiple healing stages. To address these issues, copper‐poly (tannic acid) nanoparticles (Cu‐PTA NPs): robust (dually crosslinked), microenvironment‐responsive, antibacterial, antioxidative, anti‐inflammatory are prepared, which hierarchically modulate infected process. Covalently polymerized via phenol‐formaldehyde condensation crosslinked with bioactive Cu 2+ , reactive preserved, efficiently entrapped PTA scaffold. The proposed strategy relieves systemic toxicity, only high oxygen species (ROS)level as stimuli can “turn on” catalytic activity implement antibacterial therapy specifically wound. Systematic tissue regeneration assessment on full‐thickness skin wounds rats demonstrates enhanced rate. Cu‐PTA NPs enables direct application exertion efficacy. This synergetic will pave way for more complicated inflammatory diseases.

Language: Английский

Citations

61
Injectable sodium alginate hydrogel loaded with plant polyphenol-functionalized silver nanoparticles for bacteria-infected wound healing DOI
Qinsheng Hu, Yong Nie, Jun Xiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123691 - 123691

Published: Feb. 20, 2023

Language: Английский

Citations

55
Research progress of polyphenols in nanoformulations for antibacterial application DOI Creative Commons
Chang Liu,

Shuhan Dong,

Xue Wang

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100729 - 100729

Published: July 11, 2023

Infectious disease is one of the top 10 causes death worldwide, especially in low-income countries. The extensive use antibiotics has led to an increase antibiotic resistance, which poses a critical threat human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown positive therapeutic effects antibacterial therapy. However, inherent physicochemical properties limit pharmaceutical effects, short half-lives, chemical instability, low bioavailability, poor water solubility. Nanoformulations promising advantages improving activity by controlling release drugs enhancing bioavailability polyphenols. In this review, we listed classification mechanisms compounds. More importantly, nanoformulations for delivery polyphenols agent were summarized, including different types nanoparticles (NPs) polymer-based NPs, metal-based lipid-based nanoscaffolds nanogels, nanofibers, nanoemulsions. At same time, also presented potential biological applications nano-system enhance ability polyphenols, aiming provide new perspective antibiotic-free treatment infectious diseases.

Language: Английский

Citations

49
Zinc‐Based Tannin‐Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair DOI
Yitao Zhao, Jintao Li, Lingli Liu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(20)

Published: March 25, 2023

Treatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through facile one-pot hydrothermal reaction zinc acetate in the presence tannic acid (TA), with or without silver nitrate (AgNO3 ), used to synthesize TA nanoparticles (Ag NPs) bulk-modified oxide (ZnO) (ZnO-TA ZnO-TA-Ag), which further composited zein fabricate porous microparticulate scaffolds for defect repair. Bulk modification significantly improves release rate antibacterial metal ions (Zn2+ >100 times that ZnO). Fast long-lasting (>35 d) Zn2+ Ag+ guaranteed capability excellent properties promoting differentiation marrow mesenchymal stem cells endogenous citric production mineralization providing considerable immunomodulatory M2 polarization macrophages. At same time, synchronously-released could scavenge reactive oxygen species (ROS) ROS produced by ions, effectively balancing osteogenesis sufficiently control infection while protecting surrounding tissue from damage, thus

Language: Английский

Citations

44
Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes DOI
Xulin Hu, Jian He,

Liang Qiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 6, 2024

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infection, caused by impaired glucose metabolism in diabetic foot patients, poses a significant obstacle to the healing process and carries high risk of being life‐threatening. Due microvascular occlusion entrenchment MRSA biofilms foot, controlling effectively treating infection remains challenging. Traditional hydrogels suffer from swelling‐related mechanical issues inadequate drug release control, limiting their applications as biomimetic extracellular matrices for wound healing. Herein, double‐network hydrogel composed polyvinyl alcohol, sodium alginate, gelatin (PSG) loaded with tea polyphenol self‐assembled magnesium nanoparticles (TP‐Mg NPs) antibacterial angiogenic properties MRSA‐infected wounds under hyperglycemic conditions is constructed. TP‐Mg@PSG exhibits enhanced strength toughness attachment recovery movement torsion. In acidic microenvironment representative wounds, degrades TP‐Mg NPs, showing excellent anti‐MRSA effect biocompatibility. Such localized controlled enhances inhibition reduces inflammatory response rats, promoting cell proliferation rapid repair. Therefore, this study presents multifunctional biomaterial system managing conditions, highlighting its potential clinical applications.

Language: Английский

Citations

38
Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials DOI Creative Commons
Xiaohang Guo, Weikang Luo,

Lingyu Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Language: Английский

Citations

34
Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies DOI

Huilong Xin,

Yuanyuan Liu, Yinan Xiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

Citations

33
Nanoarchitectonics of in Situ Antibiotic-Releasing Acicular Nanozymes for Targeting and Inducing Cuproptosis-like Death to Eliminate Drug-Resistant Bacteria DOI
Zhiyuan Hu,

Jie Shan,

Xu Jin

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 24327 - 24349

Published: Aug. 22, 2024

A series of progress has been made in the field antimicrobial use nanozymes due to their superior stability and decreased susceptibility drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) complex wound environments low targeting ability catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach bacteria; these exhibit OXD-like GSH-px-like dual enzyme activities produce ROS induce bacterial cuproptosis-like death, thereby eliminating MDRO infections. The results

Language: Английский

Citations

27