ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(7), С. 9135 - 9149
Опубликована: Фев. 8, 2023
Tumor
recurrence
and
metastasis
are
the
main
causes
of
cancer
mortality;
traditional
chemotherapeutic
drugs
have
severe
toxicity
side
effects
in
treatment.
To
overcome
these
issues,
here,
we
present
a
pH-responsive,
self-destructive
intelligent
nanoplatform
for
magnetic
resonance/fluorescence
dual-mode
image-guided
mitochondrial
membrane
potential
damage
(MMPD)/photodynamic
(PDT)/photothermal
(PTT)/immunotherapy
breast
treatment
with
external
near
infrared
(NIR)
light
irradiation.
do
so,
construct
multifunctional
monolayer-layered
double
hydroxide
(LDH)
nanosheets
(MICaP),
co-loading
indocyanine
green
(ICG)
ultrahigh
loading
content
realized
via
electrostatic
interactions,
calcium
phosphate
(Ca3(PO4)2)
coating
biomineralization.
Such
combined
therapy
design
is
featured
by
outstanding
biocompatibility
provokes
immunogenic
cell
death
(ICD)
tumors
toward
immunotherapy.
The
active
transport
excess
Ca2+
released
from
pH-sensitive
Ca3(PO4)2
can
induce
MMPD
tumor
cells
to
minimize
oxygen
consumption
microenvironment
(TME).
presence
ICG
not
only
generates
singlet
(1O2)
apoptosis
photodynamic
(PDT)
but
also
initiates
necrosis
photothermal
(PTT)
under
near-infrared
radiation.
Eventually,
immune
response
generated
MMPD/PDT/PTT
greatly
promotes
cytotoxic
T
lymphocyte
(CTL)
that
limit
growth
metastasis.
Both
vitro
vivo
studies
indeed
illustrate
antitumor
efficiency
outcomes.
We
anticipate
such
precisely
designed
nanoformulations
contribute
useful
advantageous
way
conducive
explore
novel
nanomedicines
notable
values
therapy.
Abstract
Layered
double
hydroxides
(LDHs)
have
been
widely
studied
for
biomedical
applications
due
to
their
excellent
properties,
such
as
good
biocompatibility,
degradability,
interlayer
ion
exchangeability,
high
loading
capacity,
pH‐responsive
release,
and
large
specific
surface
area.
Furthermore,
the
flexibility
in
structural
composition
ease
of
modification
LDHs
makes
it
possible
develop
specifically
functionalized
meet
needs
different
applications.
In
this
review,
recent
advances
applications,
which
include
LDH‐based
drug
delivery
systems,
cancer
diagnosis
therapy,
tissue
engineering,
coatings,
functional
membranes,
biosensors,
are
comprehensively
discussed.
From
these
various
research
fields,
can
be
seen
that
there
is
great
potential
possibility
use
However,
at
same
time,
must
recognized
actual
clinical
translation
still
very
limited.
Therefore,
current
limitations
related
on
discussed
by
combining
limited
examples
with
requirements
biomaterials.
Finally,
an
outlook
future
provided.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(9), С. 4490 - 4606
Опубликована: Янв. 1, 2024
This
review
discusses
recent
advances,
challenges,
future
research
directions
and
perspectives
in
biomineralized
tissues,
providing
in-depth
insights
into
derived
guidelines
for
design
preparation
of
high-performance
biomimetic
materials.
Although
artificial
bone
repair
scaffolds,
such
as
titanium
alloy,
bioactive
glass,
and
hydroxyapatite
(HAp),
have
been
widely
used
for
treatment
of
large-size
defects
or
serious
destruction,
they
normally
exhibit
unsatisfied
efficiency
because
their
weak
osteogenic
angiogenesis
performance
well
poor
cell
crawling
adhesion
properties.
Herein,
the
surface
functionalization
MgAlEu-layered
double
hydroxide
(MAE-LDH)
nanosheets
on
porous
HAp
scaffolds
is
reported
a
simple
effective
strategy
to
prepare
HAp/MAE-LDH
enhanced
regeneration.
The
MAE-LDHs
scaffold
can
significantly
improve
its
roughness,
specific
surface,
hydrophilicity,
thus
effectively
boosting
cells
differentiation.
Importantly,
grown
enable
sustained
release
Mg
Bone
diseases
including
bone
defects,
infections,
osteoarthritis,
and
tumors
seriously
affect
life
quality
of
the
patient
bring
serious
economic
burdens
to
social
health
management,
for
which
current
clinical
treatments
bear
dissatisfactory
therapeutic
effects.
Biomaterial-based
strategies
have
been
widely
applied
in
treatment
orthopedic
but
are
still
plagued
by
deficient
bioreactivity.
With
development
nanotechnology,
layered
double
hydroxides
(LDHs)
with
adjustable
metal
ion
composition
alterable
interlayer
structure
possessing
charming
physicochemical
characteristics,
versatile
bioactive
properties,
excellent
drug
loading
delivery
capabilities
arise
widespread
attention
achieved
considerable
achievements
disease
last
decade.
However,
authors'
best
knowledge,
no
review
has
comprehensively
summarized
advances
LDHs
treating
so
far.
Herein,
advantages
disorders
outlined
corresponding
state-of-the-art
first
time.
The
potential
LDHs-based
nanocomposites
extended
therapeutics
is
highlighted
perspectives
scaffold
design
proposed
facilitated
translation.
Bioactive Materials,
Год журнала:
2023,
Номер
27, С. 200 - 215
Опубликована: Апрель 10, 2023
The
regeneration
of
hierarchical
osteochondral
units
is
challenging
due
to
difficulties
in
inducing
spatial,
directional
and
controllable
differentiation
mesenchymal
stem
cells
(MSCs)
into
cartilage
bone
compartments.
Emerging
organoid
technology
offers
new
opportunities
for
regeneration.
In
this
study,
we
developed
gelatin-based
microcryogels
customized
using
hyaluronic
acid
(HA)
hydroxyapatite
(HYP),
respectively
(denoted
as
CH-Microcryogels
OS-Microcryogels)
through
vivo
self-assembly
organoids.
showed
good
cytocompatibility
induced
chondrogenic
osteogenic
MSCs,
while
also
demonstrating
the
ability
self-assemble
organoids
with
no
delamination
biphasic
cartilage-bone
structure.
Analysis
by
mRNA-seq
that
promoted
inhibited
inflammation,
OS-Microcryogels
facilitated
suppressed
immune
response,
regulating
specific
signaling
pathways.
Finally,
engraftment
pre-differentiated
canine
defects
resulted
spontaneous
assembly
an
unit,
simultaneous
both
articular
subchondral
bone.
conclusion,
novel
approach
generating
self-assembling
utilizing
tailor-made
presents
a
highly
promising
avenue
advancing
field
tissue
engineering.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(5)
Опубликована: Дек. 12, 2023
Bone
defects
stemming
from
tumorous
growths,
traumatic
events,
and
diverse
conditions
present
a
profound
conundrum
in
clinical
practice
research.
While
bone
has
the
inherent
ability
to
regenerate,
substantial
anomalies
require
regeneration
techniques.
organoids
represent
new
concept
this
field,
involving
3D
self-assembly
of
bone-associated
stem
cells
guided
vitro
with
or
without
extracellular
matrix
material,
resulting
tissue
that
mimics
structural,
functional,
genetic
properties
native
tissue.
Within
scientific
panorama,
ascend
an
esteemed
status,
securing
significant
experimental
endorsement.
Through
synthesis
current
literature
pioneering
studies,
review
offers
comprehensive
survey
organoid
paradigm,
delves
into
quintessential
architecture
ontogeny
bone,
highlights
latest
progress
fabrication.
Further,
existing
challenges
prospective
directions
for
future
research
are
identified,
advocating
interdisciplinary
collaboration
fully
harness
potential
burgeoning
domain.
Conclusively,
as
technology
continues
mature,
its
implications
both
landscapes
poised
be
profound.
Journal of Materiomics,
Год журнала:
2023,
Номер
9(5), С. 930 - 958
Опубликована: Март 31, 2023
Over
the
last
decades,
bone
tissue
engineering
has
increasingly
become
a
research
focus
in
field
of
biomedical
engineering,
which
biomaterials
play
an
important
role
because
they
can
provide
both
biomechanical
support
and
osteogenic
microenvironment
process
regeneration.
Among
these
biomaterials,
two-dimensional
(2D)
nanomaterials
have
recently
attracted
considerable
interest
owing
to
their
fantastic
physicochemical
biological
properties
including
great
biocompatibility,
excellent
capability,
large
specific
surface
area,
outstanding
drug
loading
capacity.
In
this
review,
we
summarize
state-of-the-art
advances
2D
for
engineering.
Firstly,
introduce
most
explored
used
advantages.
We
then
highlight
cutting-edge
such
as
graphene
its
derivatives,
layered
double
hydroxides,
black
phosphorus,
transition
metal
dichalcogenides,
montmorillonite,
hexagonal
boron
nitride,
graphite
phase
carbon
carbonitrides
(MXenes)
Finally,
current
challenges
future
prospects
regeneration
clinical
translation
are
discussed.
Abstract
This
review
highlights
recent
advancements
in
the
synthesis,
processing,
properties,
and
applications
of
2D‐material
integrated
hydrogels,
with
a
focus
on
their
performance
bone‐related
applications.
Various
synthesis
methods
types
2D
nanomaterials,
including
graphene,
graphene
oxide,
transition
metal
dichalcogenides,
black
phosphorus,
MXene
are
discussed,
along
strategies
for
incorporation
into
hydrogel
matrices.
These
composite
hydrogels
exhibit
tunable
mechanical
high
surface
area,
strong
near‐infrared
(NIR)
photon
absorption
controlled
release
capabilities,
making
them
suitable
range
regeneration
therapeutic
In
cancer
therapy,
2D‐material‐based
show
promise
photothermal
photodynamic
therapies,
drug
delivery
(chemotherapy).
The
properties
these
materials
enable
selective
tumor
ablation
upon
NIR
irradiation,
while
drug‐loading
capacity
facilitates
targeted
chemotherapeutic
agents.
Additionally,
2D‐materials
‐infused
potent
antibacterial
activity,
effective
against
multidrug‐resistant
infections
disruption
biofilm
generated
implant
surface.
Moreover,
synergistic
therapy
approach
combines
multiple
treatment
modalities
such
as
photothermal,
chemo,
immunotherapy
to
enhance
outcomes.
bio‐imaging,
serve
versatile
contrast
agents
imaging
probes,
enabling
real‐time
monitoring
during
imaging.
Furthermore,
bone
regeneration,
most
incorporated
promote
osteogenesis
tissue
offering
potential
solutions
defects
repair.
Overall,
integration
presents
promising
platform
developing
multifunctional
theragenerative
biomaterials.
