Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152675 - 152675
Опубликована: Июнь 1, 2024
Язык: Английский
Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.
Язык: Английский
Процитировано
63
Nature Reviews Materials, Год журнала: 2023, Номер 9(2), С. 100 - 118
Опубликована: Дек. 22, 2023
Язык: Английский
Процитировано
59
Advanced Science, Год журнала: 2024, Номер 11(23)
Опубликована: Апрель 3, 2024
Abstract Cuproptosis is an emerging cell death pathway that depends on the intracellular Cu ions. Elesclomol (ES) as efficient ionophore can specifically transport into mitochondria and trigger cuproptosis. However, ES be rapidly removed metabolized during intravenous administration, leading to a short half‐life limited tumor accumulation, which hampers its clinical application. Here, study develops reactive oxygen species (ROS)‐responsive polymer (PCP) based cinnamaldehyde (CA) polyethylene glycol (PEG) encapsulate ES‐Cu compound (EC), forming ECPCP. ECPCP significantly prolongs systemic circulation of EC enhances accumulation. After cellular internalization, PCP coating stimulatingly dissociates exposing high‐level ROS, releases Cu, thereby triggering via Meanwhile, 2+ ‐stimulated Fenton‐like reaction together with CA‐stimulated ROS production simultaneously breaks redox homeostasis, compensates for insufficient oxidative stress treated alone, in turn inducing immunogenic cells, achieving simultaneous cuproptosis immunotherapy. Furthermore, excessive accelerates stimuli‐dissociation ECPCP, positive feedback therapy loop against self‐alleviation. Therefore, nanoplatform immunotherapy improves dual antitumor mechanism provides potential optimization
Язык: Английский
Процитировано
50
Acta Biomaterialia, Год журнала: 2024, Номер 180, С. 1 - 17
Опубликована: Апрель 10, 2024
This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.
Язык: Английский
Процитировано
48
Heliyon, Год журнала: 2024, Номер 10(3), С. e25521 - e25521
Опубликована: Фев. 1, 2024
Nanomaterials (NMs) have garnered significant attention in recent decades due to their versatile applications a wide range of fields. Thanks tiny size, enhanced surface modifications, impressive volume-to-surface area ratio, magnetic properties, and customized optical dispersion. NMs experienced an incredible upsurge biomedical including diagnostics, therapeutics, drug delivery. This minireview will focus on notable examples that tackle important issues, demonstrating various aspects such as design, synthesis, morphology, classification, use cutting-edge applications. Furthermore, we classified outlined the distinctive characteristics advanced nanoscale particles hybrid NMs. Meanwhile, emphasize potential metal-organic frameworks (MOFs), highly group These MOFs gained recognition promising candidates for bio-applications, bioimaging, biosensing, antiviral therapy, anticancer nanomedicines, theranostics, immunotherapy, photodynamic photothermal gene Although shown great field, clinical is still limited by issues stability, cytotoxicity, biocompatibility, health concerns. review article provides thorough analysis offering valuable insights researchers investigating explore new development, expansion opportunities. Remarkably, ponder prospects nanocomposites conjunction with current technology.
Язык: Английский
Процитировано
29
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3432 - 3456
Опубликована: Май 13, 2024
The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.
Язык: Английский
Процитировано
25
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Язык: Английский
Процитировано
24
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(12), С. 2950 - 2984
Опубликована: Янв. 1, 2024
This review highlights the design and engineering of ZnO based 0–3D nano-architectures, thin films coatings with tunable characteristics for multifunctional biomedical applications.
Язык: Английский
Процитировано
23
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Язык: Английский
Процитировано
8
Advanced Science, Год журнала: 2022, Номер 10(6)
Опубликована: Дек. 25, 2022
Abstract Nano‐immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions properties, usually organic inorganic, have engineered integrated functions enormous potential boosting immunotherapy. This review provides summary hybrid reported immunotherapy, including nanoscale metal–organic frameworks, metal–phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer–lipid, biomacromolecule‐based nanomaterials. The combination chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic photothermal photodynamic sonodynamic therapy based on is also discussed. Finally, the current challenges prospects designing their application are outlined.
Язык: Английский
Процитировано
72