Bioengineering,
Journal Year:
2023,
Volume and Issue:
10(8), P. 892 - 892
Published: July 27, 2023
MicroRNAs
(miRNAs)
comprise
a
class
of
non-coding
RNA
with
extensive
regulatory
functions
within
cells.
MiR-106a
is
recognized
for
its
super-regulatory
roles
in
vital
processes.
Hence,
the
analysis
expression
association
diseases
has
attracted
considerable
attention
molecular
diagnosis
and
drug
development.
Numerous
studies
have
investigated
miR-106
target
genes
shown
that
this
miRNA
regulates
some
critical
cell
cycle
apoptosis
factors,
suggesting
miR-106a
as
an
ideal
diagnostic
prognostic
biomarker
therapeutic
potential.
Furthermore,
reported
correlation
between
level
cancer
resistance
demonstrated
complexity
different
tissues.
In
study,
we
conducted
comprehensive
review
on
levels
various
cancers
other
diseases,
emphasizing
genes.
The
promising
findings
surrounding
suggest
potential
valuable
biomolecule.
However,
further
validation
assessments
overcoming
existing
limitations
are
crucial
steps
before
clinical
implementation
can
be
realized.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 21, 2024
Fluorescence
imaging
(FLI)-guided
phototheranostics
using
emission
from
the
second
near-infrared
(NIR-II)
window
show
significant
potential
for
cancer
diagnosis
and
treatment.
Clinical
imaging-used
polymethine
ionic
indocyanine
green
(ICG)
dye
is
widely
adopted
NIR
fluorescence
imaging-guided
photothermal
therapy
(PTT)
research
due
to
its
exceptional
photophysical
properties.
However,
ICG
has
limitations
such
as
poor
photostability,
low
conversion
efficiency
(PCE),
short-wavelength
peak,
liver-targeting
issues,
which
restrict
wider
use.
In
this
study,
two
derivatives
are
transformed
into
neutral
merocyanines
(mCy)
achieve
much-enhanced
performance
NIR-II
phototheranostics.
Initial
designs
of
dyes
similar
drawbacks
in
terms
photostability
performance.
One
modified
molecules,
mCy890,
shows
significantly
improved
stability,
an
peak
over
1000
nm,
a
high
PCE
51%,
all
considerably
outperform
ICG.
vivo
studies
demonstrate
that
nanoparticles
mCy890
can
effectively
accumulate
at
tumor
sites
guided
by
imaging.
This
provides
valuable
insights
development
enhanced
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(5), P. 1121 - 1138
Published: Jan. 24, 2024
Human
serum
albumin
(HSA)
acts
as
a
repository
and
transporter
of
substances
in
the
blood.
An
abnormal
concentration
may
indicate
occurrence
liver-
kidney-related
diseases,
which
has
attracted
people
to
investigate
precise
quantification
HSA
body
fluids.
Fluorescent
probes
can
combine
with
covalently
or
noncovalently
quantify
urine
plasma.
Moreover,
combined
improve
its
photophysical
properties;
probe-HSA
been
applied
real-time
monitoring
photothermal
photodynamic
therapy
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(3)
Published: Nov. 24, 2022
The
signal-to-noise
ratio
(SNR)
is
one
of
the
key
features
a
fluorescent
probe
and
that
often
defines
its
potential
utility
for
in
vivo
labeling
analyte
detection
applications.
Here,
it
reported
introducing
pyridine
group
into
traditional
cyanine-7
dyes
an
asymmetric
manner
provides
series
tunable
NIR
(Cy-Mu-7)
characterized
by
enhanced
Stokes
shifts
(≈230
nm)
compared
to
parent
cyanine
7
dye
(<25
nm).
observed
shift
increase
ascribed
symmetry
breaking
Cy-Mu-7
core
reduction
extent
conjugation.
fluorescence
signals
are
upon
confinement
within
hydrophobic
cavity
albumin
or
via
spontaneous
encapsulation
micelles
aqueous
media.
Utilizing
Cy-Mu-7,
ultra-fast
kidney
mice
realized,
found
liver
injury
will
aggravate
burden
monitoring
intensity
liver.
In
addition,
could
be
used
as
efficient
chemiluminescence
resonance
energy
transfer
acceptor
reaction
between
H
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(16)
Published: Feb. 27, 2024
Abnormal
physiological
processes
and
diseases
can
lead
to
content
or
activity
fluctuations
of
biocomponents
in
organelles
whole
blood.
However,
precise
monitoring
these
abnormalities
remains
extremely
challenging
due
the
insufficient
sensitivity
accuracy
available
fluorescence
probes,
which
be
attributed
background
arising
from
two
sources,
1)
biocomponent
autofluorescence
(BCAF)
2)
probe
intrinsic
(PIF).
To
overcome
obstacles,
we
have
re-engineered
far-red
NIR
II
rhodol
derivatives
that
possess
weak
BCAF
interference.
And
a
series
"zero"
PIF
sensing-platforms
were
created
by
systematically
regulating
open-loop/spirocyclic
forms.
Leveraging
advancements,
devised
various
ultra-sensitive
indicators,
achieving
substantial
boosts
(190
1300-fold).
Among
8-LAP
demonstrated
accurate
tracking
quantifying
leucine
aminopeptidase
(LAP)
blood
at
stages
tumor
metastasis.
Furthermore,
coupling
with
an
endoplasmic
reticulum-targeting
element
enabled
detection
ERAP1
HCT116
cells
p53
abnormalities.
This
delicate
design
eliminating
provides
insights
into
enhancing
existing
probes
toward
imaging
abnormal
diseases.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Molecular
phototheranostic
dyes
are
of
eminent
interest
for
oncological
diagnosis
and
imaging‐guided
phototherapy.
However,
it
remains
challenging
to
develop
photosensitizers
(PSs)
that
simultaneously
integrate
high‐contrast
photoacoustic
imaging
efficient
therapeutic
capabilities.
In
this
work,
a
supramolecular
strategy
is
employed
construct
molecular
pair
agent
via
the
direct
self‐assembly
two
cyanines,
C5TNa
(anionic)
Cy‐Et
(cationic).
The
Coulombic
interactions
between
facilitate
formation
complementary
cyanine
(C5T‐ET)
creation
CT‐J‐type
aggregates
in
water.
This
results
completely
quenched
fluorescence
significantly
enhances
nonradiative
deactivation
(≈22
ps),
leading
3.3‐fold
increase
photothermal
conversion
efficiency
7.1‐fold
enhancement
response
compared
indocyanine
green
(ICG).
As
result,
J‐type
aggregate
demonstrates
high
capability
remarkable
antitumor
efficacy
vivo,
highlighting
its
potential
clinical
applications.
work
provides
strong
experimental
evidence
superior
performance
enhancing
photosensitization
response.
It
believed
will
propel
advancement
controllable
dye
J‐aggregates
contribute
practical
implementation
phototherapy
vivo.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
136(11)
Published: Dec. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
