Microchemical Journal, Год журнала: 2025, Номер 213, С. 113683 - 113683
Опубликована: Апрель 17, 2025
Язык: Английский
Angewandte Chemie, Год журнала: 2023, Номер 136(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
23
Chemical Engineering Journal, Год журнала: 2023, Номер 464, С. 142767 - 142767
Опубликована: Апрель 3, 2023
Язык: Английский
Процитировано
18
Chemical Reviews, Год журнала: 2024, Номер 124(16), С. 9225 - 9375
Опубликована: Авг. 13, 2024
Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.
Язык: Английский
Процитировано
8
Chemical Communications, Год журнала: 2024, Номер 60(35), С. 4691 - 4694
Опубликована: Янв. 1, 2024
The first fluorescent sensor based on the indicator displacement assay (IDA) for on-site determination of etomidate.
Язык: Английский
Процитировано
6
Sensors and Actuators B Chemical, Год журнала: 2023, Номер 398, С. 134687 - 134687
Опубликована: Сен. 27, 2023
Язык: Английский
Процитировано
12
Advanced Science, Год журнала: 2023, Номер 11(7)
Опубликована: Дек. 8, 2023
Pentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited-state properties. Herein, a synthetic approach attaching aryl substituents at the C2' position thio-pentamethine (TCy5) dye structure is reported first time. C2'-aryl substitution enables regulation both twisted intramolecular charge transfer (TICT) photoinduced electron (PET) mechanisms to be regulated in excited state. Modulation these allows design nitroreductase-activatable TCy5 fluorophore hypoxic tumor photodynamic therapy These provide tunable platform engineering tailored sophisticated biological applications, such as therapy.
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 6, 2024
Abstract Tailored photophysical properties and chemical activity is the ultimate pursuit of functional dyes for in vivo biomedical theranostics. In this work, independent regulation absorption fluorescence emission wavelengths heptamethine cyanines reported. These retain near‐infrared (except a nitro‐modified dye) while feature variable ranging from 590 to 860 nm. This enables obtain customized that meet excitation wavelength requirements defined by optical tissues applications. Typically, photothermal active derivative Cy‐Mu‐7‐9 used, which features strong at 810 nm PBS, balanced tissue penetration depth non‐specific effect, realize non‐destructive inflammatory bowel disease (IBD) therapy via induced up‐regulation heat shock protein 70 intestinal epithelial cells. The corresponding amino‐modified dye Cy‐Mu‐7‐9‐NH 2 , can be formed health enteric cavity after oral administration, compound with 800 PBS. Based on IBD sensitive transformation theranostic therapeutic effect evaluation realized synergy imaging first time.
Язык: Английский
Процитировано
4
Inorganica Chimica Acta, Год журнала: 2023, Номер 555, С. 121589 - 121589
Опубликована: Май 20, 2023
Язык: Английский
Процитировано
9
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(13)
Опубликована: Фев. 8, 2024
Abstract Liposomes serve as promising and versatile vehicles for drug delivery. Tracking these nanosized vesicles, particularly in vivo , is crucial understanding their pharmacokinetics. This study introduces the design synthesis of three new conjugated electrolyte (CE) molecules, which emit second near‐infrared window (NIR‐II), facilitating deeper tissue penetration. Additionally, CEs, acting biomimetics lipid bilayers, demonstrate superior compatibility with membranes compared to commonly used carbocyanine dyes like DiR . To counteract aggregation‐caused quenching effect, CEs employ a twisted backbone, such fluorescence intensities can effectively enhance after fluorophore multimerization strategy. Notably, “passive” method was employed integrate into liposomes during liposome formation, membrane incorporation efficiency significantly promoted nearly 100%. validate tracking capability, CE‐containing were functionalized cyclic arginine‐glycine‐aspartic acid (cRGD) peptides, serving tumor‐targeting ligands. Clear fluorescent images visualizing tumor site living mice captured by collecting NIR‐II emission. Uniquely, exhibit additional emission peak visible region, enabling vitro subcellular analysis using routine confocal microscopy. These results underscore potential new‐generation membrane‐targeting probes facilitate liposome‐based medicine research.
Язык: Английский
Процитировано
3
Analytical Chemistry, Год журнала: 2024, Номер 96(8), С. 3498 - 3507
Опубликована: Фев. 16, 2024
The development of small-molecular fluorogenic tools for the chemo-selective labeling proteins in live cells is important evaluation intracellular redox homeostasis. Dynamic imaging human serum albumin (HSA), an antioxidant protein under oxidative stress with concomitant release drugs to maintain homeostasis, affords potential opportunities disease diagnosis and treatment. In this work, we developed a nonfluorogenic prodrug named TPA-NAC, by introducing N-acetyl-l-cysteine (NAC) into conjugated acceptor skeleton. Through combined thiol amino addition, coupling HSA results fluorescence turn-on drug release. It was reasoned that restricted intramolecular motion probe microenvironment after covalent bonding inhibited nonradiative transitions. Furthermore, biocompatibility photochemical properties TPA-NAC enabled it image exogenous endogenous living wash-free manner. Additionally, released evoked upregulation superoxide dismutase (SOD), which synergistically eliminated reactive oxygen species drug-induced liver injury model. This study provides insights design new theranostic fluorescent prodrugs treatments.
Язык: Английский
Процитировано
3