Overview of miR-106a Regulatory Roles: from Cancer to Aging DOI Creative Commons
Maryam Daneshpour,

Ali Ghadimi‐Daresajini

Bioengineering, Journal Year: 2023, Volume and Issue: 10(8), P. 892 - 892

Published: July 27, 2023

MicroRNAs (miRNAs) comprise a class of non-coding RNA with extensive regulatory functions within cells. MiR-106a is recognized for its super-regulatory roles in vital processes. Hence, the analysis expression association diseases has attracted considerable attention molecular diagnosis and drug development. Numerous studies have investigated miR-106 target genes shown that this miRNA regulates some critical cell cycle apoptosis factors, suggesting miR-106a as an ideal diagnostic prognostic biomarker therapeutic potential. Furthermore, reported correlation between level cancer resistance demonstrated complexity different tissues. In study, we conducted comprehensive review on levels various cancers other diseases, emphasizing genes. The promising findings surrounding suggest potential valuable biomolecule. However, further validation assessments overcoming existing limitations are crucial steps before clinical implementation can be realized.

Language: Английский

In-situ gastritis diagnosis by an oral-administration NIR fluorescent probe with a large Stokes shift and high signal-to-noise ratio DOI
Yanyan Ma, Jie Niu, Xing Liang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 464, P. 142767 - 142767

Published: April 3, 2023

Language: Английский

Citations

18
Ratiometric determination of etomidate based on an albumin-based indicator displacement assay (IDA) DOI
Yutian Zhao,

Yanan Guo,

Zhongyong Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(35), P. 4691 - 4694

Published: Jan. 1, 2024

The first fluorescent sensor based on the indicator displacement assay (IDA) for on-site determination of etomidate.

Language: Английский

Citations

6
Rational design of donor-acceptor fluorescent probe for the ratiometric point-of-care testing of human serum albumin DOI
Zihao Chen, Zhongyong Xu, Tianyi Qin

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 398, P. 134687 - 134687

Published: Sept. 27, 2023

Language: Английский

Citations

12
Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes DOI

Maidileyvis C. Cabello,

Gen Chen, Michael J. Melville

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(16), P. 9225 - 9375

Published: Aug. 13, 2024

Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.

Language: Английский

Citations

4
Debut of enzyme-responsive anionic cyanine for overlap-free NIR-II-to-I dual-channel tumour imaging DOI Creative Commons

Feiyi Chu,

Bin Feng,

Yiyang Zhou

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: 16(10), P. 4490 - 4500

Published: Jan. 1, 2025

Bridging the disparity between traditional surgical resection imaging and ex vivo histopathology, fluorescence is considered a promising tool in disease diagnosis navigation. Nevertheless, its usefulness undermined by variability of single-wavelength signals limited penetration NIR-I (650-900 nm) bioimaging. In this work, we present novel NIR-II ratiometric fluorescent probe (CFC-GSH) with γ-glutamyl transpeptidase (GGT) sensitivity for multifunctional This leverages GSH-capped anionic cyanine, advantages high brightness, excellent photostability, specificity favourable biocompatibility. CFC-GSH exhibits an intrinsically stable signal prior to triggering, which can be utilized systemic circulation vessel outlining microvascular imaging. At tumour site GGT over expression, intramolecular S,N-rearrangement would initiate conversion sulphur-substituted cyanine amino-substituted resulting significant emission shift 270 nm. Using dual-channel changes, effectively differentiates subcutaneous hepatocellular carcinoma (HCC) normal tissue precisely localizes metastatic HCC tumours abdominal cavity. These results reveal that potential as multiprospective candidate screening diagnostic various biological scenarios.

Language: Английский

Citations

0
Fluorescent PyrAte-(S)-citalopram Conjugates Enable Imaging of the Serotonin Transporter in Living Tissue DOI Creative Commons
Oliver John V. Belleza, Iakovos Saridakis, Nadja K. Singer

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We deploy a new class of fluorophores, PyrAtes, in the first-time use small-molecule fluorophore–drug conjugates imaging endogenous SERT ex vivo .

Language: Английский

Citations

0
In Situ Lighting-Up Near-Infrared Metabolic Probes for Super-Resolution Imaging of Glycogen DOI
Dan Li,

Ruilong Dai,

Shangjun Chen

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

High-fidelity tracking of glycogen dynamics in living biosystems is critical for exploring the biological role metabolism diseases. However, situ information on state mainly relies a glucose uptake fluorescence probe 2-NBDG, which has proven to be extremely limited owing "always-on" fluorescence, short emission wavelength, and low signal-to-noise (S/N) ratio. Herein, we first time demonstrate metabolic-activated off-on through covalently attaching molecular rotor with hydrophilic at C-2 position guarantee good miscibility complete fluorescence-off before metabolic incorporation into particles. The Glycogen-Red achieves negligible background (1/30 times than 2-NBDG) an ultrahigh S/N ratio (61-fold lighting-up near-infrared (NIR) biosynthesis. Notably, our unique characteristic bypassing washing steps, offering powerful toolbox real-time biosynthesis super-resolution mapping structures cells.

Language: Английский

Citations

0
A Simple Fluorescent Probe for Biothiols Detection and Imaging of Living Cells In Vivo Based on a Hemicyanine Derivative DOI
Xia Gao, Xuehan Liu, Xiaoping Zheng

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers DOI Creative Commons

Fuping Han,

Syed Ali Abbas Abedi, Shan He

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(7)

Published: Dec. 8, 2023

Pentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited-state properties. Herein, a synthetic approach attaching aryl substituents at the C2' position thio-pentamethine (TCy5) dye structure is reported first time. C2'-aryl substitution enables regulation both twisted intramolecular charge transfer (TICT) photoinduced electron (PET) mechanisms to be regulated in excited state. Modulation these allows design nitroreductase-activatable TCy5 fluorophore hypoxic tumor photodynamic therapy These provide tunable platform engineering tailored sophisticated biological applications, such as therapy.

Language: Английский

Citations

10
NIR‐II Conjugated Electrolytes as Biomimetics of Lipid Bilayers for In Vivo Liposome Tracking DOI

Yingying Meng,

Ji Gao,

Peirong Zhou

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(13)

Published: Feb. 8, 2024

Abstract Liposomes serve as promising and versatile vehicles for drug delivery. Tracking these nanosized vesicles, particularly in vivo , is crucial understanding their pharmacokinetics. This study introduces the design synthesis of three new conjugated electrolyte (CE) molecules, which emit second near‐infrared window (NIR‐II), facilitating deeper tissue penetration. Additionally, CEs, acting biomimetics lipid bilayers, demonstrate superior compatibility with membranes compared to commonly used carbocyanine dyes like DiR . To counteract aggregation‐caused quenching effect, CEs employ a twisted backbone, such fluorescence intensities can effectively enhance after fluorophore multimerization strategy. Notably, “passive” method was employed integrate into liposomes during liposome formation, membrane incorporation efficiency significantly promoted nearly 100%. validate tracking capability, CE‐containing were functionalized cyclic arginine‐glycine‐aspartic acid (cRGD) peptides, serving tumor‐targeting ligands. Clear fluorescent images visualizing tumor site living mice captured by collecting NIR‐II emission. Uniquely, exhibit additional emission peak visible region, enabling vitro subcellular analysis using routine confocal microscopy. These results underscore potential new‐generation membrane‐targeting probes facilitate liposome‐based medicine research.

Language: Английский

Citations

3