Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 547 - 567

Опубликована: Авг. 15, 2023

Язык: Английский

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Nanoarchitectonics of Hollow Covalent Organic Frameworks: Synthesis and Applications

ACS Nano, Год журнала: 2023, Номер 17(10), С. 8918 - 8934

Опубликована: Май 2, 2023

Hollow covalent organic frameworks (COFs) have gained significant attention because of their specific properties, including enhanced surface-to-volume ratio, large surface area, hierarchical structure, highly ordered nanostructures, and excellent chemical stability. These intrinsic characteristics endow hollow COFs with fascinating physicochemical properties make them attractive for widespread applications, such as catalysis, energy storage, drug delivery, therapy, sensing, environmental remediation. This review focuses on the recent developments in synthesis derivatives. In addition, practical applications various fields are summarized. Finally, challenges future opportunities terms synthetic methodologies discussed. expected to play an important role materials science.

Язык: Английский

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Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor‐Specific and Ferroptosis‐Augmented Sonodynamic Therapy

Advanced Science, Год журнала: 2023, Номер 10(6)

Опубликована: Янв. 3, 2023

Abstract Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs‐based nanosensitizers with uniform nanoscale morphology and tumor‐specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls synthesized a controlled manner engineered as activatable sonodynamic activity. High crystallinity ensures an ordered porous structure of the efficient loading small‐molecule sonosensitizer rose bengal (RB). To circumvent non‐specific damage to normal tissues, sonosensitization effect specifically inhibited by situ growth manganese oxide (MnO x ) on RB‐loaded COFs. Upon reaction tumor‐overexpressed glutathione (GSH), “gatekeeper” MnO rapidly decomposed recover reactive oxygen species (ROS) generation capability under ultrasound irradiation. Increased intracellular ROS stress GSH consumption concomitantly induce ferroptosis improve efficacy. Additionally, unconventional bowl‐shaped renders enhanced tumor accumulation retention. The combination therapy achieves efficacy killing cancer cells inhibiting growth. This study paves way development morphologies biomedicine, offering paradigm realize ferroptosis‐augmented therapy.

Язык: Английский

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Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)

Опубликована: Март 10, 2023

The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small-molecule photosensitizers. Herein, we report that the reticular chemistry-based synthesis from two inert monomers yields a COF-based sonosensitizer (TPE-NN) inherent activity. Subsequently, nanoscale COF TPE-NN fabricated and embedded copper (Cu)-coordinated sites to obtain TPE-NN-Cu. Results show Cu coordination can enhance effect TPE-NN, whereas ultrasound (US) irradiation for therapy augment chemodynamic efficacy Consequently, TPE-NN-Cu upon US shows high-performance anticancer based on mutually reinforced sono-/chemo-nanodynamic therapy. This study reveals backbone-originated activity proposes paradigm nanodynamic

Язык: Английский

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Review of irradiation treatments on MOFs and COFs: Synthesis, modification, and application

Separation and Purification Technology, Год журнала: 2024, Номер 339, С. 126636 - 126636

Опубликована: Фев. 4, 2024

Язык: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

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Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Апрель 6, 2024

Abstract Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with short blood half‐life, face challenges in transporting enough amounts ions into tumor cells. This work describes construction carrier‐free nanoparticles (Ce6@Cu NPs), which self‐assembled by coordination 2+ sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic‐triggered combination cuproptosis and ferroptosis. Ce6@Cu NPs internalized U87MG cells induce sonodynamic effect glutathione (GSH) depletion capability, promoting lipid peroxidation eventually inducing Furthermore, + concentration increases as reacts reductive GSH, resulting downregulation ferredoxin‐1 lipoyl synthase. induces oligomerization lipoylated dihydrolipoamide S‐acetyltransferase, causing proteotoxic stress irreversible cuproptosis. possess satisfactory ability to penetrate blood‐brain barrier, significant accumulation orthotopic U87MG‐Luc glioblastoma. The ferroptosis evidenced both vitro vivo minimal side effects. represents promising therapeutic strategy combining cuproptosis, potentially inspiring further research developing logical effective cancer therapies based

Язык: Английский

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Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO₂ Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

ACS Nano, Год журнала: 2023, Номер 17(13), С. 12544 - 12562

Опубликована: Июнь 24, 2023

To achieve the maximum therapeutic effects and minimize adverse of trimodal synergistic tumor therapies, a cost-effective programmed photothermal (PTT)-chemodynamic (CDT)-coordinated dual drug chemotherapy (CT) therapy strategy in chronological order is proposed. According to status or volumes tumors, intensity time each modality are optimized, three modalities combined programmatically work order. The optimal begins with high-intensity PTT for 10 min ablate larger followed by medium-intensity CDT several hours eliminate medium-sized then low-intensity coordinated drugs CT lasts over 48 h clear smaller residual tumors. Composite nanoparticles, made Fe-coordinated polydopamine mixed copper peroxide as cores their surface dotted lots doxorubicin-Fe(III)-gossypol infinite coordination polymers (ICPs), have been developed implement strategy. These composite nanoparticles show excellent minimum dose agents result nearly 100% inhibition mice bearing PC-3 tumors no observed recurrence within 60 days treatment. ratios different can be adjusted accommodate types this

Язык: Английский

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Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Язык: Английский

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Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Год журнала: 2024, Номер 24(4), С. 1284 - 1293

Опубликована: Янв. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Язык: Английский

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