ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
11(1), С. 429 - 441
Опубликована: Дек. 19, 2024
Chemotherapeutic
drugs
often
fail
to
localize
efficiently
tumors
when
administered
intravenously,
causing
off-target
effects.
This
study
proposes
an
autologous
erythrocyte
(ER)-anchoring
strategy
improve
chemotherapy
efficacy
and
reduce
side
Utilizing
a
modified
hemodialysis
instrument,
closed-system
drug-transfer
device
was
developed
for
ER
procurement
immunogenicity
mitigation.
Doxorubicin
(DOX)
indocyanine
green
(ICG)
were
encapsulated
in
ERs
then
with
DSPE-PEG-FA.
The
final
product,
DOX-ICG@ER-D,
reintroduced
into
circulation
enhance
chemotherapy.
These
obtained
DOX-ICG@ER-D
showed
good
stability,
minimal
cardiotoxicity,
extended
time.
Compared
free
DOX,
had
higher
accumulation
of
DOX
hepatocellular
carcinoma
the
release
could
be
controlled
by
laser
irradiation.
Tumor-bearing
rats
treated
these
demonstrated
improved
antitumor
reduced
cardiotoxicity.
Thus,
this
ER-anchoring
offers
promising
alternative
intravenous
clinic.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 20, 2024
Recent
research
in
artificial
cell
production
holds
promise
for
the
development
of
delivery
agents
with
therapeutic
effects
akin
to
real
cells.
To
succeed
these
applications,
systems
need
survive
circulatory
conditions.
In
this
review
we
present
strategies
that,
inspired
by
endurance
red
blood
cells,
have
enhanced
viability
large,
cell-like
vehicles
vivo
use,
particularly
focusing
on
giant
unilamellar
vesicles.
Insights
from
cells
can
guide
modifications
that
could
transform
platforms
into
advanced
drug
vehicles,
showcasing
biomimicry's
potential
shaping
future
applications.
Abstract
Immunotherapy
has
recently
emerged
as
a
promising
therapeutic
modality
for
the
treatment
of
various
diseases
such
cancer,
inflammation,
autoimmune
diseases,
and
infectious
diseases.
Despite
its
potential,
immunotherapy
faces
challenges
related
to
delivery
efficiency
off‐target
toxicity
immunotherapeutic
drugs.
Nano
drug
systems
offer
improvements
in
biodistribution
release
kinetics
but
still
suffer
from
shortcomings
high
immunogenicity,
poor
penetration
across
biological
barriers,
insufficient
tissue
permeability.
Targeted
drugs
using
living
cells
become
an
emerging
strategy
that
can
take
advantage
inherent
characteristics
deal
with
defects
nano
systems.
Furthermore,
themselves
be
genetically
engineered
into
cellular
enhanced
immunotherapy.
This
review
provides
in‐depth
exploration
cell‐derived
carriers,
detailing
their
properties,
functions,
commonly
used
loading
strategies.
In
addition,
role
modified
synergistic
effects
are
also
introduced.
By
summarizing
main
advancements
limitations
field,
this
offers
insights
potential
cell‐based
address
existing
The
introduction
recent
developments
evaluation
ongoing
research
will
pave
way
optimization
widespread
adoption
nano/genetically
Applied Sciences,
Год журнала:
2024,
Номер
14(5), С. 1939 - 1939
Опубликована: Фев. 27, 2024
Atherosclerosis,
a
disease
that
mainly
affects
human
blood
vessels,
can
cause
various
cerebral
ischaemic
diseases
such
as
coronary
heart
and
peripheral
arterial
disease.
However,
conventional
drugs
for
the
treatment
of
atherosclerosis
have
disadvantages
low
bioavailability
high
toxicity.
Bowl-shaped
particles
not
only
excellent
properties
traditional
spherical
particles,
improved
drug
distribution,
increased
absorption,
reduced
toxicity
side
effects,
but
also
are
easier
to
circulate
in
long
time,
immune
rejection
larger
specific
surface
area.
Chitosan/polycaprolactone
bowl-shaped
were
prepared
via
electrostatic
spraying,
effects
precursor
solution
concentration
polymer
ratio
on
particle
morphology
investigated.
composite
containing
hirudin
under
optimal
parameters
sustained
anticoagulation.
The
anticoagulant
molecules
could
be
continuously
released
from
scaffold
bowl
degraded.
biocompatibility
haemocompatibility
assessed
using
mouse
glial
cells
rabbit
blood,
results
showed
cell
viability
drug-loaded
was
overall
above
90%
haemolysis
rate
below
2%.
By
controlling
release
hirudin,
achieve
long-term
delivery
system
wider
application
potential
novel
contact
material.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Фев. 8, 2024
Abstract
Blood
scarcity
is
one
of
the
main
causes
healthcare
disruptions
worldwide,
with
blood
shortages
occurring
at
an
alarming
rate.
Over
last
decades,
substitutes
have
aimed
reinforcing
supply
blood,
several
products
(e.g.,
hemoglobin
(Hb)‐based
oxygen
(O
2
)
carriers,
perfluorocarbons
(PFC))
achieving
a
limited
degree
success.
Regardless,
there
still
no
widespread
solution
to
this
problem
due
persistent
challenges
in
product
safety
and
scalability.
In
Review,
different
advances
are
described
field
substitution,
particularly
development
artificial
red
cells,
otherwise
known
as
engineered
erythrocytes
(EE).
The
strategies
categorized
into
natural,
synthetic,
or
hybrid
approaches,
discuss
their
potential
terms
Synthetic
EEs
identified
most
powerful
approach,
describe
from
materials
engineering
perspective.
Their
biological
structure
function
reviewed,
well
explore
methods
assembling
material‐based
cell.
Specifically,
it
discussed
how
recreate
size,
shape,
deformability
through
particle
fabrication,
functional
machinery
synthetic
biology
nanotechnology.
It
concluded
by
describing
versatile
nature
medicine
pharmaceuticals
propose
specific
directions
for
erythrocyte
engineering.
Synthesis lectures on biomedical engineering,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 1, 2025
Abstract
This
chapter
discusses
the
current
theoretical
and
practical
applications
of
ultrasound-assisted
or
vibratory
blood
flow
activation
bioparticle
separation
technologies.
The
disadvantages
high
megahertz
ultrasound,
which
is
widely
used
in
medical
practice
for
diagnostic
sometimes
therapeutic
purposes,
are
related
to
limited
penetration
depth
acoustic
signal,
scattered
effect
on
biological
tissues
overheating.
Emphasis
placed
use
ultrasound
activate
delivery
drugs
target
by
disrupting
biofilm
covering
bacteria
and,
at
same
time,
antibiotics
treatment
inflammatory
processes.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2813 - 2846
Опубликована: Март 1, 2025
Abstract:
Metal-based
nanoparticles
(MNPs)
have
great
potential
for
applications
in
wound
healing
and
tissue
engineering,
due
to
their
unique
structures,
high
bioactivities,
excellent
designability
characteristics,
an
increasing
number
of
studies
been
devoted
modifying
these
species
generate
novel
composites
with
desirable
optical,
electrical,
magnetic
properties.
However,
few
systematic
detailed
reviews
performed
relating
the
modification
approaches
available
MNPs
resulting
composites.
In
this
review,
a
comprehensive
summary
is
regarding
optimized
formulations
application
dressings,
techniques
used
prepare
composite
dressings
are
discussed.
addition,
safety
profiles
nanocomposite
limitations
reported
systems
evaluated.
More
importantly,
solution
strategies
proposed
address
limitations.
Overall,
review
provides
new
ideas
design
facilitate
field
skin
repair,
also
looks
into
future
direction
biomedical
field.
Keywords:
metal-based
nanoparticles,
nanocomposite,
dressing,
multi-functional,
Abstract
Erythrocytes
are
the
most
abundant
cells
in
blood.
As
results
of
long‐term
natural
selection,
their
specific
biconcave
discoid
morphology
and
cellular
composition
responsible
for
gaining
excellent
biological
performance.
Inspired
by
intrinsic
features
erythrocytes,
various
artificial
biomaterials
emerge
find
broad
prospects
biomedical
applications
such
as
therapeutic
delivery,
bioimaging,
tissue
engineering.
Here,
a
comprehensive
review
from
fabrication
to
erythrocyte‐inspired
functional
materials
is
given.
After
summarizing
mimicking
functions
synthesis
strategies
particles
with
morphologies
presented.
The
emphasis
on
practical
these
bioinspired
materials.
perspectives
future
possibilities
advanced
also
discussed.
It
hoped
that
summary
existing
studies
can
inspire
researchers
develop
novel
biomaterials;
thus,
accelerating
progress
toward
clinical
applications.
