Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Язык: Английский

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Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

Advanced Science, Год журнала: 2023, Номер 10(10)

Опубликована: Фев. 5, 2023

Due to radiation resistance and the immunosuppressive microenvironment of metastatic osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) antitumor immunity synchronously urgently needed. Here, authors developed a nanoscale metal-organic framework (MOF, named TZM) by co-doping high-atomic elements Ta Zr as metal nodes porphyrinic molecules (tetrakis(4-carboxyphenyl)porphyrin (TCPP)) photosensitizing ligand. Given 3D arrays ultra-small heavy metals, porous TZM serves an efficient attenuator absorbing X-ray energy sensitizing hydroxyl radical generation for RT. Ta-Zr narrowed highest occupied molecular orbital-lowest unoccupied orbital (HOMO-LUMO) gap exhibited close levels between singlet triplet photoexcited states, facilitating transfer photosensitizer TCPP oxygen (

Язык: Английский

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Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129391 - 129391

Опубликована: Янв. 20, 2024

Язык: Английский

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Oxygen-Independent Radiodynamic Therapy: Radiation-Boosted Chemodynamics for Reprogramming the Tumor Immune Environment and Enhancing Antitumor Immune Response

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(17), С. 21546 - 21556

Опубликована: Апрель 16, 2024

Radiodynamic therapy (RDT) has emerged as a promising modality for cancer treatment, offering notable advantages such deep tissue penetration and radiocatalytic generation of oxygen free radicals. However, the oxygen-dependent nature RDT imposes limitations on its efficacy in hypoxic conditions, particularly modulating eliminating radioresistant immune suppression cells. A novel approach involving creation "super" tetrahedron polyoxometalate (POM) cluster, Fe12-POM, been developed radiation boosted chemodynamic catalysis to enable oxygen-independent conditions. This nanoscale cluster comprises four P2W15 units functioning energy antennas, while Fe3 core serves an electron receptor catalytic center. Under X-ray radiation, metal-to-metal charge transfer phenomenon occurs between core, resulting valence transition Fe3+ Fe2+ remarkable 139-fold increase hydroxyl radical compared Fe12-POM alone. The rapid radicals, combination with PD-1 therapy, induces reprogramming environment within tumors. is characterized by upregulation CD80/86, downregulation CD163 FAP, well release interferon-γ tumor necrosis factor-α. Consequently, occurrence abscopal effects facilitated, leading significant regression both local distant tumors mice. development represents address recurrence improve treatment outcomes.

Язык: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6399 - 6444

Опубликована: Янв. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Язык: Английский

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Recent advances in metal-based nanomaterials for malignant bone tumor therapy

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 288, С. 117427 - 117427

Опубликована: Фев. 20, 2025

Язык: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391

Опубликована: Ноя. 15, 2023

Язык: Английский

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Recent advances on nanostructured biomaterials in osteosarcoma treatment

Coordination Chemistry Reviews, Год журнала: 2023, Номер 493, С. 215315 - 215315

Опубликована: Июнь 24, 2023

Язык: Английский

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Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

Advanced Science, Год журнала: 2024, Номер 11(29)

Опубликована: Июнь 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Язык: Английский

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High-Z elements dominated bismuth-based heterojunction nano-semiconductor for radiotherapy-enhanced sonodynamic breast cancer therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 914 - 927

Опубликована: Фев. 9, 2024

Язык: Английский

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