Cation-free siRNA micelle knockdown of EPHA2 improves sensitivity of imatinib for osteosarcoma treatment DOI
Yunlong Wang, Mengting Wang, Jianhui Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162705 - 162705

Published: April 1, 2025

Language: Английский

Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma DOI Creative Commons
Tao Li,

Mingquan Gao,

Zifei Wu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(10)

Published: Feb. 5, 2023

Due to radiation resistance and the immunosuppressive microenvironment of metastatic osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) antitumor immunity synchronously urgently needed. Here, authors developed a nanoscale metal-organic framework (MOF, named TZM) by co-doping high-atomic elements Ta Zr as metal nodes porphyrinic molecules (tetrakis(4-carboxyphenyl)porphyrin (TCPP)) photosensitizing ligand. Given 3D arrays ultra-small heavy metals, porous TZM serves an efficient attenuator absorbing X-ray energy sensitizing hydroxyl radical generation for RT. Ta-Zr narrowed highest occupied molecular orbital-lowest unoccupied orbital (HOMO-LUMO) gap exhibited close levels between singlet triplet photoexcited states, facilitating transfer photosensitizer TCPP oxygen (

Language: Английский

Citations

47
Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis DOI

Beixu Li,

Milad Ashrafizadeh,

Taiwei Jiao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129391 - 129391

Published: Jan. 20, 2024

Language: Английский

Citations

45
Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation DOI
Chen Zhao, Weihua Song,

Jianing Wang

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Language: Английский

Citations

34
Immunological nanomaterials to combat cancer metastasis DOI

Yuanbo Pan,

Junjie Cheng, Yang Zhu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444

Published: Jan. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Language: Английский

Citations

21
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

38
Recent advances on nanostructured biomaterials in osteosarcoma treatment DOI

Chengcheng Feng,

Yechun Jiang,

Tao Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 493, P. 215315 - 215315

Published: June 24, 2023

Language: Английский

Citations

23
Oxygen-Independent Radiodynamic Therapy: Radiation-Boosted Chemodynamics for Reprogramming the Tumor Immune Environment and Enhancing Antitumor Immune Response DOI
Yang Chen, Yong Deng, Yiran Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21546 - 21556

Published: April 16, 2024

Radiodynamic therapy (RDT) has emerged as a promising modality for cancer treatment, offering notable advantages such deep tissue penetration and radiocatalytic generation of oxygen free radicals. However, the oxygen-dependent nature RDT imposes limitations on its efficacy in hypoxic conditions, particularly modulating eliminating radioresistant immune suppression cells. A novel approach involving creation "super" tetrahedron polyoxometalate (POM) cluster, Fe12-POM, been developed radiation boosted chemodynamic catalysis to enable oxygen-independent conditions. This nanoscale cluster comprises four P2W15 units functioning energy antennas, while Fe3 core serves an electron receptor catalytic center. Under X-ray radiation, metal-to-metal charge transfer phenomenon occurs between core, resulting valence transition Fe3+ Fe2+ remarkable 139-fold increase hydroxyl radical compared Fe12-POM alone. The rapid radicals, combination with PD-1 therapy, induces reprogramming environment within tumors. is characterized by upregulation CD80/86, downregulation CD163 FAP, well release interferon-γ tumor necrosis factor-α. Consequently, occurrence abscopal effects facilitated, leading significant regression both local distant tumors mice. development represents address recurrence improve treatment outcomes.

Language: Английский

Citations

15
High-Z elements dominated bismuth-based heterojunction nano-semiconductor for radiotherapy-enhanced sonodynamic breast cancer therapy DOI

Lejin Zhu,

Guobo Chen, Qian Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 914 - 927

Published: Feb. 9, 2024

Language: Английский

Citations

13
Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization DOI Creative Commons

Rui Qiao,

Zhongwen Yuan,

Meijin Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Language: Английский

Citations

13
Cu2WS4‐PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno‐Radiotherapy by Inducing Ferroptosis DOI Creative Commons
Shiyan Fu,

Yong Li,

Li Shen

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Feb. 7, 2024

Unavoidable damage to normal tissues and tumor microenvironment (TME) resistance make it challenging eradicate breast carcinoma through radiotherapy. Therefore, is urgent develop radiotherapy sensitizers that can effectively reduce radiation doses reverse the suppressive TME. Here, a novel biomimetic PEGylated Cu

Language: Английский

Citations

9