Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Язык: Английский
International Immunopharmacology, Год журнала: 2024, Номер 137, С. 112394 - 112394
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
8
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Дек. 4, 2024
Abstract The dynamic regulation of chromatin accessibility is one the prominent characteristics eukaryotic genome. inaccessible regions are mainly located in heterochromatin, which multilevel compressed and access restricted. remaining accessible loci generally euchromatin, have less nucleosome occupancy higher regulatory activity. opening most important prerequisite for DNA transcription, replication, damage repair, regulated by genetic, epigenetic, environmental, other factors, playing a vital role multiple biological progresses. Currently, based on susceptibility difference occupied or free to enzymatic cleavage, solubility, methylation, transposition, there many methods detect both bulk single-cell level. Through combining with high-throughput sequencing, genome-wide landscape tissues cells types also been constructed. feature distinct different states. Research network crucial uncovering secret various processes. In this review, we comprehensively introduced major functions mechanisms variation physiological pathological processes, meanwhile, targeted therapies dynamics summarized.
Язык: Английский
Процитировано
8
Bioorganic Chemistry, Год журнала: 2024, Номер 144, С. 107175 - 107175
Опубликована: Фев. 3, 2024
Язык: Английский
Процитировано
7
Organic Letters, Год журнала: 2024, Номер 26(27), С. 5695 - 5699
Опубликована: Июнь 24, 2024
One rare stephacidin-asperochratide hybrid, stephaochratidin A (1), was isolated from the deep-sea-derived Aspergillus ochraceus MCCC 3A00521. The relative structure of 1 determined by comprehensive analyses its 1D and 2D NMR data as well HRESIMS data. And absolute configuration unambiguously assigned ECD calculations X-ray single-crystal diffraction analysis. Plausible biosynthetic pathway proposed. Stephaochratidin (1) exhibited significant ferroptosis inhibitory activity with EC50 value 15.4 μM downregulating HMOX-1 expression lipid peroxidation.
Язык: Английский
Процитировано
7
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2623 - 2643
Опубликована: Март 1, 2025
In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties low toxicity, good tolerance, biocompatibility, and biodegradability new nanomaterials, a drug delivery system (TDDS) has been constructed, which can boost therapeutic effect hepatoma-targeted drugs, reduce minimize off target reactions by enhancing permeability retention (EPR) active targeting, thus existing liver cancer therapy strategies. Different nanoparticles have their own advantages disadvantages. They be loaded with multiple drugs on same nanoparticle also surface modified each other to achieve synergistic anti-tumor effects. This essay provides comprehensive overview current status hepatocarcinoma, nanoparticles' structure, disadvantages nanoparticle, application progress cancer. We hope provide basis future clinical hepatoma using nanotechnology.
Язык: Английский
Процитировано
1
Molecular Biomedicine, Год журнала: 2025, Номер 6(1)
Опубликована: Март 5, 2025
Inflammation is a multifaceted defense mechanism of the immune system against infection. Chronic inflammation intricately linked to all stages tumorigenesis and therefore associated with an elevated risk developing serious cancers. Epigenetic mechanisms have capacity trigger as well facilitate tumor development transformation within inflammatory context. They achieve this by dynamically modulating expression both pro-inflammatory anti-inflammatory cytokines, which in turn sustains chronic inflammation. The aberrant epigenetic landscape reconfigures transcriptional programs oncogenic genes. This reconfiguration pivotal dictating biological functions cells cells. Aberrant histone H3 lysine 27 site (H3K27) methylation has been shown be involved behaviors such development, progression, response. establishment maintenance repressive mark dependent on involvement responsible modifying enzymes enhancer zeste homologue 2 (EZH2), jumonji domain containing 3 (JMJD3) ubiquitously transcribed tetratricopeptide repeat gene X (UTX) multiple cofactors. In addition, specific pharmacological agents modulate H3K27 levels, thereby carcinogenesis. review comprehensively summarises current characteristics clinical significance regulation context response progression.
Язык: Английский
Процитировано
1
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Апрель 9, 2025
The most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and well-known as a research issue recent years since it alters metabolism involved numerous biological processes. Currently, m6A alteration offers new opportunities clinical applications intimately linked to carcinogenesis. Ferroptosis-a iron-dependent, lipid peroxidation-induced regulated cell death-was discovered. In the development cancer, an important factor. According newly available data, ferroptosis regulates tumor growth, cancer exhibits aberrant levels crucial regulatory components. On other hand, multiple roles tumors, relationship between m6A-modified malignancies quite intricate. this review, we first give thorough review functional methylation, focusing on molecular processes through regulation human progression metastasis, which are strongly associated initiation, progression, drug resistance. Therefore, clarify m6A-mediated providing strategy for treatment with substantial implications.
Язык: Английский
Процитировано
1
Aging, Год журнала: 2023, Номер 15(22), С. 12952 - 12965
Опубликована: Ноя. 16, 2023
Colorectal cancer is one of the most common malignant tumors in digestive system, and its high incidence metastasis rate make it a terrible killer that threatens human health. In-depth exploration targets affecting progression colorectal cells development specific targeted drugs for them are great significance prognosis patients. Erythropoietin-producing hepatocellular A2 (EphA2) member Eph subfamily with tyrosine kinase activity, plays key role regulation signaling pathways related to phenotype various tumor cells, but regulatory mechanism needs be further clarified. Here, we found EphA2 was abnormally highly expressed patients expression had worse prognosis. We also can form liquid-liquid phase separation condensates on cell membrane, which disrupted by ALW-II-41-27, an inhibitor EphA2. In addition, positively correlated ferroptosis-related genes infiltration multiple immune cells. These findings suggest novel membrane protein ability associated ferroptosis infiltration, suggests may inhibited suppressing
Язык: Английский
Процитировано
13
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Апрель 22, 2024
Ferroptosis is caused by the accumulation of cellular reactive oxygen species that exceed antioxidant load glutathione (GSH) and phospholipid hydroperoxidases with GSH-based substrates can carry When capacity cells reduced, lipid accumulate, which cause oxidative death. Ferroptosis, an iron-dependent regulatory necrosis pathway, has emerged as a new modality cell death strongly associated cancer. Surgery, chemotherapy radiotherapy are main methods cancer treatment. However, resistance to these mainstream anticancer drugs strong toxic side effects have forced development alternative treatments high efficiency low toxicity. In recent years, increasing number studies shown traditional Chinese medicines (TCMs), especially herbs or herbal extracts, inhibit tumor growth metastasis inducing ferroptosis, suggesting they could be promising agents for This article reviews current research progress on antitumor TCMs through induction ferroptosis. The aim was elucidate potential mechanisms targeting ferroptosis in cancer, findings lead directions reference values developing better treatment strategies.
Язык: Английский
Процитировано
4
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 122(1)
Опубликована: Дек. 31, 2024
Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role GPX4 in regulating ferroptosis, our understanding protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as regulator protein. Inhibition expression enhances ubiquitination-mediated degradation up-regulating E3 ubiquitin ligase RC3H1. Using both rescue assays and functional genetic demonstrate that pharmacologically targeting triggers ferroptosis liver cells. Moreover, show synergizes with sorafenib or regorafenib to induce across multiple types. These findings elucidate modulatory effects MALT1-RC3H1 axis on stability, revealing molecular mechanism could be exploited
Язык: Английский
Процитировано
4