Progress in the Application of Novel Nanomaterials in Targeted Therapy for Liver Cancer DOI Creative Commons
Xin Wei,

Weihua Cao,

Shiyu Wang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2623 - 2643

Published: March 1, 2025

In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties low toxicity, good tolerance, biocompatibility, and biodegradability new nanomaterials, a drug delivery system (TDDS) has been constructed, which can boost therapeutic effect hepatoma-targeted drugs, reduce minimize off target reactions by enhancing permeability retention (EPR) active targeting, thus existing liver cancer therapy strategies. Different nanoparticles have their own advantages disadvantages. They be loaded with multiple drugs on same nanoparticle also surface modified each other to achieve synergistic anti-tumor effects. This essay provides comprehensive overview current status hepatocarcinoma, nanoparticles' structure, disadvantages nanoparticle, application progress cancer. We hope provide basis future clinical hepatoma using nanotechnology.

Language: Английский

Anti-necroptosis and anti-ferroptosis compounds from the Deep-Sea-Derived fungus Aspergillus sp. MCCC 3A00392 DOI
Haoyu Yu, Yushi Chen,

Yuan Wang

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 144, P. 107175 - 107175

Published: Feb. 3, 2024

Language: Английский

Citations

7
Asiatic acid induces ferroptosis of RA-FLS via the Nrf2/HMOX1 pathway to relieve inflammation in rheumatoid arthritis DOI

Miao Sun,

Qian Wang,

Jianhua Huang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112394 - 112394

Published: June 12, 2024

Language: Английский

Citations

7
Stephaochratidin A, a Rare Stephacidin-Asperochratide Hybrid with Ferroptosis Inhibitory Activity from the Deep-Sea-Derived Aspergillus ochraceus DOI

Zheng‐Biao Zou,

Yan Li,

Yuan Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(27), P. 5695 - 5699

Published: June 24, 2024

One rare stephacidin-asperochratide hybrid, stephaochratidin A (1), was isolated from the deep-sea-derived Aspergillus ochraceus MCCC 3A00521. The relative structure of 1 determined by comprehensive analyses its 1D and 2D NMR data as well HRESIMS data. And absolute configuration unambiguously assigned ECD calculations X-ray single-crystal diffraction analysis. Plausible biosynthetic pathway proposed. Stephaochratidin (1) exhibited significant ferroptosis inhibitory activity with EC50 value 15.4 μM downregulating HMOX-1 expression lipid peroxidation.

Language: Английский

Citations

6
Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application DOI Creative Commons
Yang Chen, Rui Liang, Yong Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 4, 2024

Abstract The dynamic regulation of chromatin accessibility is one the prominent characteristics eukaryotic genome. inaccessible regions are mainly located in heterochromatin, which multilevel compressed and access restricted. remaining accessible loci generally euchromatin, have less nucleosome occupancy higher regulatory activity. opening most important prerequisite for DNA transcription, replication, damage repair, regulated by genetic, epigenetic, environmental, other factors, playing a vital role multiple biological progresses. Currently, based on susceptibility difference occupied or free to enzymatic cleavage, solubility, methylation, transposition, there many methods detect both bulk single-cell level. Through combining with high-throughput sequencing, genome-wide landscape tissues cells types also been constructed. feature distinct different states. Research network crucial uncovering secret various processes. In this review, we comprehensively introduced major functions mechanisms variation physiological pathological processes, meanwhile, targeted therapies dynamics summarized.

Language: Английский

Citations

5
EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer DOI Creative Commons

Yanling Li,

Peng Qiu,

Lujuan Wang

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(22), P. 12952 - 12965

Published: Nov. 16, 2023

Colorectal cancer is one of the most common malignant tumors in digestive system, and its high incidence metastasis rate make it a terrible killer that threatens human health. In-depth exploration targets affecting progression colorectal cells development specific targeted drugs for them are great significance prognosis patients. Erythropoietin-producing hepatocellular A2 (EphA2) member Eph subfamily with tyrosine kinase activity, plays key role regulation signaling pathways related to phenotype various tumor cells, but regulatory mechanism needs be further clarified. Here, we found EphA2 was abnormally highly expressed patients expression had worse prognosis. We also can form liquid-liquid phase separation condensates on cell membrane, which disrupted by ALW-II-41-27, an inhibitor EphA2. In addition, positively correlated ferroptosis-related genes infiltration multiple immune cells. These findings suggest novel membrane protein ability associated ferroptosis infiltration, suggests may inhibited suppressing

Language: Английский

Citations

13
TCM targets ferroptosis: potential treatments for cancer DOI Creative Commons

Liwen Qin,

Yuhan Zhong,

Yi Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 22, 2024

Ferroptosis is caused by the accumulation of cellular reactive oxygen species that exceed antioxidant load glutathione (GSH) and phospholipid hydroperoxidases with GSH-based substrates can carry When capacity cells reduced, lipid accumulate, which cause oxidative death. Ferroptosis, an iron-dependent regulatory necrosis pathway, has emerged as a new modality cell death strongly associated cancer. Surgery, chemotherapy radiotherapy are main methods cancer treatment. However, resistance to these mainstream anticancer drugs strong toxic side effects have forced development alternative treatments high efficiency low toxicity. In recent years, increasing number studies shown traditional Chinese medicines (TCMs), especially herbs or herbal extracts, inhibit tumor growth metastasis inducing ferroptosis, suggesting they could be promising agents for This article reviews current research progress on antitumor TCMs through induction ferroptosis. The aim was elucidate potential mechanisms targeting ferroptosis in cancer, findings lead directions reference values developing better treatment strategies.

Language: Английский

Citations

4
Deciphering the role of the MALT1–RC3H1 axis in regulating GPX4 protein stability DOI Creative Commons
Jun Wang, Long Liao, Beiping Miao

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)

Published: Dec. 31, 2024

Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role GPX4 in regulating ferroptosis, our understanding protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as regulator protein. Inhibition expression enhances ubiquitination-mediated degradation up-regulating E3 ubiquitin ligase RC3H1. Using both rescue assays and functional genetic demonstrate that pharmacologically targeting triggers ferroptosis liver cells. Moreover, show synergizes with sorafenib or regorafenib to induce across multiple types. These findings elucidate modulatory effects MALT1-RC3H1 axis on stability, revealing molecular mechanism could be exploited

Language: Английский

Citations

4
CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis DOI Creative Commons
Xi Yan,

Yinghao Niu,

Yaojie Wang

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

This study aims to investigate the role and mechanism of p-hydroxyl cinnamaldehyde (CMSP) in triggering ferroptosis small cell lung cancer (SCLC) cells. The impact CMSP on H1688 SW1271 cells was assessed through experiments biological information analysis. Moreover, expression heme oxygenase 1 (HMOX1) SCLC tissue examined. Following treatment, a concentration-dependent increase death observed, differentially expressed genes were found be associated with ferroptosis. notably facilitated events, such as elevated levels reactive oxygen species (ROS), Fe2+, malondialdehyde (MDA), transferrin receptor (TFR1), divalent metal transporter (DMT1), decreased glutathione (GSH), solute carrier family 7 member 11 (SLC7A11), peroxidase 4 (GPX4). Furthermore, promoted mitochondrial dysfunction, manifested reduced volume, increased membrane density, ROS, potential. Consistently, mitochondrial-targeted antioxidant Mito-TEMPO reversed CMSP-induced Expression HMOX1 gene markedly under while lower observed compared adjacent tissue. triggers dysfunction via activation, leading cells, underscoring its potential therapeutic agent for SCLC.

Language: Английский

Citations

0
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis DOI
Chengniu Wang, Xiaoran Li, Taowen Ye

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108170 - 108170

Published: Jan. 16, 2025

Language: Английский

Citations

0
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells DOI Creative Commons
Zheng Zhang, Huaxiang Xu,

Junyi He

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 18, 2025

As a novel form of nonapoptotic cell death, ferroptosis is developing into promising therapeutic target dedifferentiating and therapy-refractory cancers. However, its application in pancreatic cancer still unknown. In the preliminary research, we found that F-box WD repeat domain-containing 7 (FBW7) inhibited migration proliferation cells through substrate c-Myc. We further another key FBW7, KLF5, could inhibit ferroptosis. Inhibiting KLF5 significantly enhances cytotoxicity oxaliplatin rather than other chemotherapy drugs. Mechanistically, expression heme oxygenase 1 (HMOX1) via repressing zinc finger E-box-binding homeobox (ZEB1). Inhibition facilitated cytotoxic effect promoting Oxaliplatin combined with inhibitor potentiated death vitro tumor growth vivo compared either treatment alone. These results reveal critical role sensitized cancer, suggest platinum-based gemcitabine-based expected to bring better effects.

Language: Английский

Citations

0