ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Июль 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
Abstract
Oral
ulcers
can
be
addressed
using
various
biomaterials
designed
to
deliver
medications
or
cytokines.
Nevertheless,
the
effectiveness
of
these
substances
is
frequently
limited
in
many
patients
due
poor
adherence,
short
retention
time
mouth,
and
less‐than‐optimal
drug
efficacy.
In
this
study,
a
new
hydrogel
patch
(FSH3)
made
silk
fibroin/hyaluronic
acid
matrix
with
light‐sensitive
adhesive
qualities
infused
ferric
iron/shikonin
nanoparticles
enhance
healing
effects
presented.
Initially,
forms
an
barrier
over
mucosal
lesions
through
straightforward
local
injection,
solidifying
when
exposed
UV
light.
Subsequently,
FSH3
demonstrates
superior
reactive
oxygen
species
elimination
near‐infrared
photothermal
bactericidal
activity.
These
characteristics
support
bacterial
regulate
oxidative
levels,
promoting
wound's
progression
from
inflammation
tissue
regeneration.
diabetic
rat
model
mimicking
oral
ulcers,
significantly
speeds
up
by
adjusting
inflammatory
environment
injured
tissue,
maintaining
balance
microbiota,
faster
re‐epithelialization.
Overall,
shows
potential
for
rapid
wound
recovery
may
transform
therapeutic
methods
managing
diabetes.
Abstract
Diabetic
ulcers
(DUs)
are
characterized
by
a
microenvironment
with
high
oxidative
stress,
blood
glucose
levels,
and
recalcitrant
bacterial
infections.
This
is
accompanied
long‐term
suppression
of
endogenous
antioxidant
systems,
which
makes
their
clinical
management
extremely
challenging.
To
address
this
issue,
hybridized
novel
gold‐palladium
(AuPd)
nanoshell
the
injectable/injectable
hydrogel
system
UiO/AuPd
shells
/BNN6/PEG@Gel
(UAPsBP@Gel)
developed.
The
capable
acting
as
nitric
oxide
(NO)
reactor
utilizing
synergistic
therapy
that
harnesses
NIR‐II
light‐triggered
photothermal
effects
controlled
release
NO
gas
for
treatment
to
eradicate
biofilm
infections
at
different
depths.
AuPd
nanoshells
exhibits
superoxide
dismutase
(SOD)‐,
oxidase
(GOx)‐,
catalase
(CAT)‐like
activities,
enabling
self‐cascade
process
scavenging
both
reactive
oxygen
species
(ROS)
glucose.
activity
reshapes
DUs
microenvironment,
switches
on
Nrf2/HO‐1
pathway
inhibits
NF‐κB
pathway,
promotes
macrophage
polarization
toward
anti‐inflammatory
M2
phenotype,
reduces
resulting
in
efficient
immunomodulation.
In
vitro
/
vivo
results
demonstrate
UAPsBP@Gel
can
multifacetedly
enhance
epithelial
rejuvenation
through
wound
hemostasis,
pro‐cellular
migration
vascularization.
These
highlight
programmed
therapeutic
based
UBAPsP@Gel
tailored
stages
infected
meet
complex
needs.
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 193 - 206
Опубликована: Июль 20, 2024
Regulating
macrophage
phenotypes
to
reconcile
the
conflict
between
bacterial
suppression
and
tissue
regeneration
is
ideal
for
treating
infectious
skin
wounds.
Here,
an
injectable
immunoregulatory
hydrogel
(SrmE20)
that
sequentially
drives
phenotypic
polarization
(M0
M1,
then
M2)
was
constructed
by
integrating
anti-inflammatory
components
proinflammatory
solvents.
