Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153103 - 153103
Опубликована: Июнь 13, 2024
Язык: Английский
MedComm, Год журнала: 2024, Номер 5(7)
Опубликована: Июнь 22, 2024
Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.
Язык: Английский
Процитировано
32
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
22
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced precision and safety. To enhance deep tissue penetration minimize adsorption phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded tumor microenvironment hypoxia, primarily caused irregular vasculature. Fortunately, stimulator interferon genes (STING) pathway, known immune activation, has been linked vasculature normalization. In this study, we developed nanoplatform (Fe-THBQ/SR) loading STING agonist (SR-717) into an iron-tetrahydroxy-1,4-benzoquinone (Fe-THBQ) metal–organic framework. Fe-THBQ was proven be effective NIR-II photosensitizer, generating numerous reactive oxygen species (ROS) under 1064 nm laser irradiation. These ROS downregulated heat shock protein expression, consequently promoting mild-photothermal (mild-PTT), facilitated ferroptosis depleting glutathione (GSH)/glutathione peroxidase 4. Moreover, Fe-THBQ/SR released SR-717 upon GSH stimulation, synergizing with ROS-mediated double-stranded DNA leakage activation. This process contributed normalization hypoxia alleviation, thereby enhancing efficacy. Overall, presented versatile single-laser-triggered mild-PTT simultaneously coupled it activation form reinforcing cycle. synergistic enhancements increased immunogenicity cells, remodeled immunosuppressive microenvironment, T lymphocyte infiltration, improved therapeutic outcomes.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2023, Номер 10(35)
Опубликована: Ноя. 8, 2023
Abstract Photodynamic therapy (PDT) has been widely employed in tumor treatment due to its effectiveness. However, the hypoxic microenvironment which is caused by abnormal vasculature severely limits efficacy of PDT. Furthermore, implicated failure immunotherapy. In this study, a novel nanoparticle denoted as Combo‐NP introduced, composed biodegradable NIR II fluorescent pseudo‐conjugate polymer featuring disulfide bonds within main chain, designated TPA‐BD, and vascular inhibitor Lenvatinib. exhibits dual functionality not only inducing cytotoxic reactive oxygen species (ROS) directly eliminate cells but also eliciting immunogenic cell death (ICD). This ICD response, turn, initiates robust cascade immune reactions, thereby augmenting generation T lymphocytes (CTLs). addition, addresses issue hypoxia normalizing vasculature. normalization process enhances PDT while concurrently fostering increased CTLs infiltration microenvironment. These synergistic effects synergize potentiate photodynamic‐immunotherapeutic properties nanoparticles. when combined with anti‐programmed death‐ligand 1 (PD‐L1), they showcase notable inhibitory on metastasis. The findings study introduce an innovative nanomedicine strategy aimed at triggering systemic anti‐tumor responses for Uveal melanoma.
Язык: Английский
Процитировано
23
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(23), С. 29672 - 29685
Опубликована: Май 30, 2024
Metastasis and recurrence are notable contributors to mortality associated with breast cancer. Although immunotherapy has shown promise in mitigating these risks after conventional treatments, its effectiveness remains constrained by significant challenges, such as impaired antigen presentation dendritic cells (DCs) inadequate T cell infiltration into tumor tissues. To address limitations, we developed a multifunctional nanoparticle platform, termed GM@P, which consisted of hydrophobic shell encapsulating the photosensitizer MHI148 hydrophilic core containing STING agonist 2'3'-cGAMP. This design elicited robust type I interferon responses activate antitumor immunity. The GM@P nanoparticles loaded specifically targeted cancer cells. Upon exposure 808 nm laser irradiation, MHI148-loaded produced toxic reactive oxygen species (ROS) eradicate through photodynamic therapy (PDT). Notably, PDT stimulated immunogenic death (ICD) foster potency immune responses. Furthermore, superior photoacoustic imaging (PAI) capabilities enabled simultaneous visualization diagnostic therapeutic procedures. Collectively, our findings uncovered that combination activation facilitated more conducive microenvironment, characterized enhanced DC maturation, CD8+ cells, proinflammatory cytokine release. strategy local augment systemic effects, offering promising approach suppress growth, inhibit metastasis, prevent recurrence.
Язык: Английский
Процитировано
8
Advanced Science, Год журнала: 2024, Номер 11(31)
Опубликована: Июнь 18, 2024
Abstract In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by suboptimal pharmacokinetics and strong self‐rescue tumor cells. To overcome these limitations, reactive oxygen species (ROS)‐responsive nanoparticles (NPs) are designed that encapsulate HDACi MS‐275 glutamine metabolism inhibitor V‐9302. Upon reaching microenvironment, NPs can disintegrate, thereby releasing to increase level ROS V‐9302 reduce production glutathione (GSH) related self‐rescue. These synergistic effects lead lethal storm induce cell pyroptosis. When combined with programmed death protein 1 monoclonal antibodies ( α ‐PD‐1), facilitate immune infiltration, improving anti‐tumor immunity, converting “immune‐cold” tumors into “immune‐hot” tumors, enhancing memory in mice. The findings present nano‐delivery strategy for co‐delivery therapeutics metabolic inhibitors, which induces pyroptosis cells improves effectiveness chemotherapy immunotherapy.
Язык: Английский
Процитировано
8
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(2), С. 35 - 35
Опубликована: Янв. 30, 2024
Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive loading the chemotherapy agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG), biocompatible low-molecular-weight heparin (LMHP) gatekeepers photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release ICG DOX. simultaneously produced oxygen (O2) reactive species (ROS) photodynamic therapy (PDT). The released under laser irradiation ROS PDT raised tumor temperature (PTT). DOX directly caused cell death chemotherapy. Both also induced immunogenic (ICD) immunotherapy. in vivo vitro results presented superior inhibition progression, metastasis recurrence. Therefore, this study could provide an efficient approach designing multifunctional therapy.
Язык: Английский
Процитировано
6
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 10129 - 10144
Опубликована: Окт. 1, 2024
Immunotherapy is a promising cancer treatment because of its ability to sustainably enhance the natural immune response. However, effects multiple immunotherapies, including ICIs, are limited by resistance these agents, immune-related adverse events, and lack reasonable therapeutic targets available at right time place. The tumor microenvironment (TME), which features tumor-associated macrophages (TAMs), plays significant role in owing hypoxic blood vessels, resulting evasion. To immunotherapy, photodynamic therapy (PDT) can increase innate adaptive responses through immunogenic cell death (ICD) improve TME. Traditional photosensitizers (PSs) also include novel nanomedicines precisely target cells or TAMs. Here, we reviewed summarized current strategies possible influencing factors for photoimmunotherapy.
Язык: Английский
Процитировано
4
Photochemistry and Photobiology, Год журнала: 2024, Номер 100(4), С. 910 - 922
Опубликована: Апрель 16, 2024
Abstract Metastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate continued development novel therapeutic options. Photoimmunotherapy (PIT) emerging as a promising strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining superior tumor‐specificity minimally invasive nature traditional PDT. In this review, we discuss advances in PIT strategies for management using PIT. can strongly induce immunogenic cell death, inviting concomitant application checkpoint blockade or adoptive therapies. also be leveraged selectively remove suppressive populations associated resistance. The modular design combined potential patient‐specific antigen selection drug co‐delivery makes alluring option future personalized care.
Язык: Английский
Процитировано
3
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(7), С. 7239 - 7257
Опубликована: Июль 8, 2024
Photodynamic therapy (PDT) can not only directly eliminate cancer cells, but also stimulate antitumor immune responses. It affects the expression of checkpoints. The purpose this review is to collect, analyze, and summarize recent news about PDT checkpoints, along with their inhibitors, identify future research directions that may enhance effectiveness approach. A search for articles published between January 2023 March 2024 was conducted in PubMed/MEDLINE. Eligibility criteria were as follows: (1) papers describing (2) original papers, (3) new reports field (4) both vitro vivo papers. Exclusion included written a language other than Polish or English, before 2023. 24 data on checkpoints have been since These information effects attempts associate ICI molecules modulate improve immunosuppressive environment tumor, resolve PDT-related problems. They focused development nanoparticles delivery photosensitizers drugs selectively tumor. effect level associated activity system has fully elucidated further, area are divergent, indicating complexity interaction system. PDT-based strategies shown beneficial utility enhancing induction response by participating triggering immunogenic cell death, exposure tumor antigens, release various alarm signals together promote activation dendritic cells components demonstrated, result induced therapy. enables multifaceted regulation tumor’s environment, which potential achieve better efficacy. current presented evidence PDT’s ability association ICIs inducing an effective against cells. However, these studies at early stage many more observations need be made confirm indicated contribute further strategies.
Язык: Английский
Процитировано
3