Immunoantitumor Activity and Oxygenation Effect Based on Iron–Copper-Doped Folic Acid Carbon Dots

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 16653 - 16668

Опубликована: Март 23, 2024

Cancer metastasis and recurrence are closely associated with immunosuppression a hypoxic tumor microenvironment. Chemodynamic therapy (CDT) photothermodynamic (PTT) have been shown to induce immunogenic cell death (ICD), effectively inhibiting cancer when combined immune adjuvants. However, the limited efficacy of Fenton's reaction suboptimal photothermal effect present significant challenges for successfully inducing ICD through CDT PTT. This paper described synthesis immunoantitumor activity novel iron–copper-doped folic acid carbon dots (CFCFB). Copper-doped (Cu-FACDs) were initially synthesized via hydrothermal method, using copper gluconate as precursors. Subsequently, nanoparticles CFCFB obtained cross-linking self-assembly Cu-FACDs ferrocene dicarboxylic (FeDA) 3-bromopyruvic (3BP). The catalytic in enhanced Fenton reaction, thereby promoting CDT-induced increasing intracellular oxygen concentration. Additionally, 3BP inhibited cellular respiration, further amplifying conversion efficiency reached 55.8%, which significantly its antitumor therapy. Immunofluorescence assay revealed that treatment led an increased expression markers, including calreticulin (CRT) ATP, well extracellular release HMGB-1, indicating induction by CFCFB. Moreover, observed downregulation ARG1 indicates transition microenvironment from immunosuppressive state following upregulation IL-2 CD8 facilitated differentiation effector T cells, resulting augmented population CD8+ activation systemic response.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Glutathione-Responsive Metal–Organic-Framework-Derived Mn_xO_y/(A/R)TiO₂ Nanoparticles for Enhanced Synergistic Sonodynamic/Chemodynamic/Immunotherapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Despite the potential of sonodynamic therapy (SDT) in treating malignant tumors, lack effective sonosensitizers has limited its clinical implementation. In this study, we explored relationship between heteroatom doping concentration metal-organic frameworks and interface formation after pyrolysis by regulating addition manganese sources successfully derived Z-scheme heterojunctions Mn

Язык: Английский

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Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.

Язык: Английский

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Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed bismuth fluoride, polyoxometalates, molybdenum carbide, significantly improves charge separation electron transfer efficiency under ultrasound irradiation, resulting an efficient water-splitting reaction. By simultaneously generating depleting glutathione, BPM effectively triggers oxidative stress alleviates hypoxia, thereby disrupting inhibiting metabolism cells. Additionally, enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, polarizing macrophages toward M1 phenotype, reversing immunosuppressive state microenvironment. results indicate that holds for gas-immunotherapy combination treatments, offering multifunctional strategy improve outcomes.

Язык: Английский

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Metal-based nanomedicines and their immunoregulatory effects

Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Язык: Английский

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Engineering nanosystems for ROS-bridged cancer cascade therapy

Chemical Engineering Journal, Год журнала: 2023, Номер 473, С. 145415 - 145415

Опубликована: Авг. 12, 2023

Язык: Английский

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Sono‐Activatable Semiconducting Polymer Nanoreshapers Multiply Remodel Tumor Microenvironment for Potent Immunotherapy of Orthotopic Pancreatic Cancer

Advanced Science, Год журнала: 2023, Номер 10(35)

Опубликована: Окт. 23, 2023

Abstract Due to the complicated tumor microenvironment that compromises efficacies of various therapies, effective treatment pancreatic cancer remains a big challenge. Sono‐activatable semiconducting polymer nanoreshapers (SPN DN H) are constructed multiply remodel orthotopic for potent immunotherapy. SPN H contain polymer, hydrogen sulfide (H 2 S) donor, and indoleamine 2,3‐dioxygenase (IDO) inhibitor (NLG919), which encapsulated by singlet oxygen ( 1 O )‐responsive shells with modification hyaluronidase (HAase). After accumulation in sites, degrade major content hyaluronic acid promote nanoparticle enrichment immune cell infiltration, also release S relieve hypoxia via inhibiting mitochondrion functions. Moreover, relieved enables amplified sonodynamic therapy (SDT) under ultrasound (US) irradiation generation , leads immunogenic death (ICD) destruction ‐responsive components realize sono‐activatable NLG919 reversing IDO‐based immunosuppression. Through such multiple remodeling mechanism, antitumor immunological effect is triggered after H‐based treatment. Therefore, growths tumors mouse models almost inhibited metastases effectively restricted. This study offers nanoplatform precise immunotherapy deep‐tissue tumors.

Язык: Английский

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Dual‐Programmable Semiconducting Polymer NanoPROTACs for Deep‐Tissue Sonodynamic‐Ferroptosis Activatable Immunotherapy

Small, Год журнала: 2023, Номер 20(8)

Опубликована: Окт. 10, 2023

Abstract Proteolysis‐targeting chimeras (PROTACs) can provide promising opportunities for cancer treatment, while precise regulation of their activities remains challenging to achieve effective and safe therapeutic outcomes. A semiconducting polymer nanoPROTAC (SPN FeP ) is reported that ultrasound (US) tumor microenvironment dual‐programmable PROTAC activity deep‐tissue sonodynamic‐ferroptosis activatable immunotherapy. SPN formed through a nano‐precipitation sonodynamic polymer, ferroptosis inducer, newly synthesized molecule. The polymers work as sonosensitizers produce singlet oxygen ( 1 O 2 via effect under US irradiation, inducers react with intratumoral hydrogen peroxide (H generate hydroxyl radical (·OH). Such reactive species (ROS) generation not only triggers immunogenic cell death (ICD), but also induces on‐demand delivery molecules into sites. effectively activated nanoPROTACs degrade nicotinamide phosphoribosyl transferase (NAMPT) suppress infiltration myeloid‐derived suppressive cells (MDSCs), thus promoting antitumor immunity. In such way, mediates immunotherapy entirely inhibiting growths in both subcutaneous 2‐cm tissue‐covered deep mouse models. This study presents strategy based on PROTACs combinational therapy.

Язык: Английский

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