Engineering Stimuli‐Responsive Materials for Precision Medicine DOI Creative Commons
Ruixuan Zheng, Yu Chang, Dan Yao

et al.

Small, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 23, 2024

Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.

Language: Английский

Immunoantitumor Activity and Oxygenation Effect Based on Iron–Copper-Doped Folic Acid Carbon Dots DOI

Siqi Li,

Hui Zhang, Yujun Bao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16653 - 16668

Published: March 23, 2024

Cancer metastasis and recurrence are closely associated with immunosuppression a hypoxic tumor microenvironment. Chemodynamic therapy (CDT) photothermodynamic (PTT) have been shown to induce immunogenic cell death (ICD), effectively inhibiting cancer when combined immune adjuvants. However, the limited efficacy of Fenton's reaction suboptimal photothermal effect present significant challenges for successfully inducing ICD through CDT PTT. This paper described synthesis immunoantitumor activity novel iron–copper-doped folic acid carbon dots (CFCFB). Copper-doped (Cu-FACDs) were initially synthesized via hydrothermal method, using copper gluconate as precursors. Subsequently, nanoparticles CFCFB obtained cross-linking self-assembly Cu-FACDs ferrocene dicarboxylic (FeDA) 3-bromopyruvic (3BP). The catalytic in enhanced Fenton reaction, thereby promoting CDT-induced increasing intracellular oxygen concentration. Additionally, 3BP inhibited cellular respiration, further amplifying conversion efficiency reached 55.8%, which significantly its antitumor therapy. Immunofluorescence assay revealed that treatment led an increased expression markers, including calreticulin (CRT) ATP, well extracellular release HMGB-1, indicating induction by CFCFB. Moreover, observed downregulation ARG1 indicates transition microenvironment from immunosuppressive state following upregulation IL-2 CD8 facilitated differentiation effector T cells, resulting augmented population CD8+ activation systemic response.

Language: Английский

Citations

9
Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Citations

9
Neutrophil-based Trojan horse containing polymer nano-therapeutics for sono-activatable ferroptosis-immunotherapy of orthotopic glioma DOI

Mengbin Ding,

Anni Zhu,

Yijing Zhang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102398 - 102398

Published: July 12, 2024

Language: Английский

Citations

8
Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity DOI Open Access
Qinyanqiu Xiang, Xue Yang, Zhi‐Qi Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.

Language: Английский

Citations

1
Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment DOI Creative Commons
Rui Zhang, Qian Wang, Junjie Pan

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed bismuth fluoride, polyoxometalates, molybdenum carbide, significantly improves charge separation electron transfer efficiency under ultrasound irradiation, resulting an efficient water-splitting reaction. By simultaneously generating depleting glutathione, BPM effectively triggers oxidative stress alleviates hypoxia, thereby disrupting inhibiting metabolism cells. Additionally, enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, polarizing macrophages toward M1 phenotype, reversing immunosuppressive state microenvironment. results indicate that holds for gas-immunotherapy combination treatments, offering multifunctional strategy improve outcomes.

Language: Английский

Citations

1
Metal-based nanomedicines and their immunoregulatory effects DOI
Hang Liu, Mingjing Cao, Chunying Chen

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

1
Engineering nanosystems for ROS-bridged cancer cascade therapy DOI
Qinrui Fu, Leilei Yu, Meihua Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145415 - 145415

Published: Aug. 12, 2023

Language: Английский

Citations

21
Sono‐Activatable Semiconducting Polymer Nanoreshapers Multiply Remodel Tumor Microenvironment for Potent Immunotherapy of Orthotopic Pancreatic Cancer DOI Creative Commons
Meng Li, Yue Liu, Yijing Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)

Published: Oct. 23, 2023

Abstract Due to the complicated tumor microenvironment that compromises efficacies of various therapies, effective treatment pancreatic cancer remains a big challenge. Sono‐activatable semiconducting polymer nanoreshapers (SPN DN H) are constructed multiply remodel orthotopic for potent immunotherapy. SPN H contain polymer, hydrogen sulfide (H 2 S) donor, and indoleamine 2,3‐dioxygenase (IDO) inhibitor (NLG919), which encapsulated by singlet oxygen ( 1 O )‐responsive shells with modification hyaluronidase (HAase). After accumulation in sites, degrade major content hyaluronic acid promote nanoparticle enrichment immune cell infiltration, also release S relieve hypoxia via inhibiting mitochondrion functions. Moreover, relieved enables amplified sonodynamic therapy (SDT) under ultrasound (US) irradiation generation , leads immunogenic death (ICD) destruction ‐responsive components realize sono‐activatable NLG919 reversing IDO‐based immunosuppression. Through such multiple remodeling mechanism, antitumor immunological effect is triggered after H‐based treatment. Therefore, growths tumors mouse models almost inhibited metastases effectively restricted. This study offers nanoplatform precise immunotherapy deep‐tissue tumors.

Language: Английский

Citations

20
Activatable Semiconducting Polymer Nanoinducers Amplify Oxidative Damage via Sono-Ferroptosis for Synergistic Therapy of Bone Metastasis DOI
Yijing Zhang, Qin Zhang,

Fengshuo Wang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(16), P. 7699 - 7708

Published: Aug. 11, 2023

Bone metastases are secondary malignant tumors that commonly occur after the spread of advanced cancer cells. We herein report activatable semiconducting polymer nanoinducers (ASPNFP) can amplify oxidative damage via sono-ferroptosis for bone metastasis treatment. ASPNFP constructed by encapsulating plasma amine oxidase-based nanoparticles (SPNP) and Fe3O4 into singlet oxygen (1O2)-responsive nanocarriers. generate 1O2 under ultrasound (US) irradiation a sonodynamic effect to destroy stability 1O2-responsive nanocarriers, allowing US-triggered releases SPNP nanoparticles. decompose polyamines in tumor cells produce acrolein hydrogen peroxide (H2O2), which H2O2 promotes Fenton reaction mediated inducing enhanced ferroptosis generation hydroxyl radicals (•OH). The generated acrolein, 1O2, •OH simultaneously damage. thus mediate an amplified inhibit growth restrict metastasis.

Language: Английский

Citations

17